Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:4.1.99.3 (
PRE
)
1,923
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
We investigated the strength of the association between oxidative stress, hypoxia inducible factor 1 (
HIF-1 alpha
) and acute hypoxic ventilatory response (AHVR) after hypoxic training in elite runners. Six elite runners were submitted to 18-day of "living high-training low" (LHTL) and six performed the same training in normoxia. AHVR was measured during an acute hypoxic test before and after training. Plasma levels of protein oxidation (AOPP), malondialdehydes and (
HIF-1 alpha
) mRNA in the leukocytes were measured before and after the acute hypoxic test. LHTL increased AHVR and amplified the responses of
HIF-1 alpha
mRNA and AOPP (Delta(AOPP)) to the acute hypoxic test. Furthermore, between
PRE
and POST, the changes in Delta(AOPP) were correlated with the changes in AHVR (r=0.69, P=0.01). The ventilatory acclimatization to hypoxia occurring in athletes after LHTL seems to be modulated by oxidative stress. Furthermore, LHTL induced a higher sensitivity of
HIF-1 alpha
mRNA to acute hypoxia in elite athletes.
...
PMID:Oxidative stress and HIF-1 alpha modulate hypoxic ventilatory responses after hypoxic training on athletes. 1938 58
