Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:4.1.2.42 (
DTA
)
1,693
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The [Zn
3
(CitH)
2
] (
1
) (CitH
4
= citric acid), was dispersed in sodium lauryl sulphate (SLS) to form the micelle of SLS@[Zn
3
(CitH)
2
] (
2
). This material
2
was incorporated in hydrogel made by hydroxyethyl-methacrylate (HEMA), an ingredient of contact lenses, toward the formation of pHEMA@(SLS@[Zn
3
(CitH)
2
]) (
3
). Samples of
1
and
2
were characterized by UV-Vis,
1
H-NMR, FT-IR, FT-Raman, single crystal X-ray crystallography, X-ray fluorescence analysis, atomic absorption and TG/
DTA
/DSC. The antibacterial activity of
1
-
3
as well as of SLS against Gram-positive
(Staphylococcus epidermidis (St. epidermidis)
and
Staphylococcus aureus (St. aureus))
and Gram-negative
(Pseudomonas aeruginosa (PAO1)
, and
Escherichia coli (
E. coli)
)
bacteria was evaluated by the means of minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC) and inhibitory zone (IZ).
2
showed 10 to 20-fold higher activity than
1
against the bacteria tested. Moreover the
3
decreases the abundance of Gram-positive microbes up to 30% (
St. aureus
) and up to 20% (PAO1) the Gram-negative ones. The noteworthy antimicrobial activity of the obtained composite
3
suggests an effective antimicrobial additive for infection-free contact lenses.
...
PMID:An Efficient Disinfectant, Composite Material {SLS@[Zn
3
(CitH)
2
]} as Ingredient for Development of Sterilized and Non Infectious Contact Lens. 3170 30
