Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:4.1.2.42 (
DTA
)
1,693
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Internalization and traffic to acidic endosomes of anthrax lethal factor (LF) and protective antigen (PA), bound to the anthrax toxin receptor (ATR), is required for LF translocation into the cytosol, where it can elicit its toxic effects. Dynamin is required for clathrin-mediated endocytosis, and long-term disruption of
dynamin
function blocks internalization of PA. We have used LFn-
DTA
, a surrogate of LF consisting of the N-terminal domain of LF fused to the catalytic subunit of diphtheria toxin, to differentiate the effects of acute and long-term block of
dynamin
function on LFn-
DTA
toxicity. Both forms of interference reduce LFn-
DTA
toxicity only partially, consistent with alternative routes for LFn-
DTA
endocytosis. In contrast, a long-term block of
dynamin
activity results in a further interference with LFn-
DTA
toxicity that is consistent with an altered endosomal environment, probably an increase in endosomal pH.
...
PMID:Effects of dynamin inactivation on pathways of anthrax toxin uptake. 1551 Oct 85
