Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:4.1.2.42 (DTA)
 1,693 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In this survey magnesium sails in the form of solid dispersions were studied to examine the interaction of the drug and lecithin or Tego Betain L-7. The results of thermal analysis of solid dispersions containing magnesium adipate Mg[Adip] and compounds of this salt with glycine substituent, and the partition coefficient (logP) of this salts applied for solid dispersion, have been presented in this paper. Lecithin (45% phosphatidylcholine) or Tego Betain L-7 (30% solution of amide betaine) have been added to magnesium salts to obtain a solid dispersion. The influence of auxiliary substances: Tego Betain L-7 and lecithin on physicochemical properties of the examined preparations has been assessed. The results of thermal analysis (DTA, DSC, TG) of magnesium complexes indicated their good thermal resistance up to the temperature of 375 K.
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PMID:Influence of selected auxiliary substances on some physicochemical properties of solid dispersions containing magnesium salts. 1549 90

A novel method was developed to make the charge-neutral and poorly water-soluble pesticide chlorpyrifos (CPF) adsolubilize into layered zinc hydroxide nitrate intercalated with dodecylbenzenesulfonate (ZHN-DBS). It included two steps: first, CPF was solubilized into the micelles formed by anionic surfactant sodium dodecylbenzenesulfonate (DBS), nonionic surfactant polyoxyethylene (10) nonyl phenyl ether (TX-10) or zwitterionic surfactant dodecyl betaine (DB), and then ZHN-DBS was poured into CPF micelles to synthesize ZHN-DBS-CPF, ZHN-TX-10-CPF, and ZHN-DB-CPF intercalated compounds. These intercalated compounds were characterized by powder X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), and thermogravimetric analysis and differential thermal analysis (TGA/DTA). The results showed that ZHN-DBS-CPF, ZHN-TX-10-CPF, and ZHN-DB-CPF had the basal spacings of 3.29-3.59, 2.57-2.87, and 1.97 nm, respectively, which was discussed from the intercalated mechanism. The intercalated CPF had the higher thermal stability. Release behaviors of CPF from intercalated compounds were investigated and analyzed in buffer solutions (pH 5.0 and 6.8). The results exhibited that the release rates and equilibrium release amounts of CPF were closely dependent on micelles types and release mediums. The release behaviors of ZHN-DBS-CPF and ZHN-TX-10-CPF were well described with pseudo second-order and parabolic diffusion models. The present study suggested that ZHN-DBS-CPF and ZHN-TX-10-CPF could be applied as a potential pesticide delivery system.
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PMID:Preparation and release behavior of chlorpyrifos adsolubilized into layered zinc hydroxide nitrate intercalated with dodecylbenzenesulfonate. 2597 May 64