Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:4.1.2.42 (
DTA
)
1,693
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Internalization and traffic to acidic endosomes of anthrax lethal factor (LF) and protective antigen (PA), bound to the
anthrax toxin receptor
(
ATR
), is required for LF translocation into the cytosol, where it can elicit its toxic effects. Dynamin is required for clathrin-mediated endocytosis, and long-term disruption of dynamin function blocks internalization of PA. We have used LFn-
DTA
, a surrogate of LF consisting of the N-terminal domain of LF fused to the catalytic subunit of diphtheria toxin, to differentiate the effects of acute and long-term block of dynamin function on LFn-
DTA
toxicity. Both forms of interference reduce LFn-
DTA
toxicity only partially, consistent with alternative routes for LFn-
DTA
endocytosis. In contrast, a long-term block of dynamin activity results in a further interference with LFn-
DTA
toxicity that is consistent with an altered endosomal environment, probably an increase in endosomal pH.
...
PMID:Effects of dynamin inactivation on pathways of anthrax toxin uptake. 1551 Oct 85
