Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:4.1.2.13 (aldolase)
 3,461 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

After intraperitoneal administration of acrylonitrile into rats, fructose monophosphate aldolase was found in blood serum, activity of butyryl cholinesterase was inhibited but activity of alkaline phosphatase was unaltered in rat blood serum; these data demonstrate the necro-bystrophic type impairment. Decrease in the hepatotoxic effect of acrylonitrile after preadministration of antioxidants appears to be a result of stimulation of lipid peroxidation, preventing the toxic effect of this industrially important substance.
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PMID:[Blood serum enzymes in assessing the nature of the liver lesion and the effectiveness of chemotherapeutic actions in acrylonitrile poisoning]. 51 33

It is known that the serum in cancer patients has the characteristics of the heat-stability. The factor produce the heat-stability is known to be due to tumor marker(TM) such as CEA, CA125(glycoprotein), CA19-9, CA15-3, SLX, CA50, CA72-4, DU-PAN-2, ST-439, SPAN-1(mucin) and alpha 1-acid glycoprotein, IAP(acute reactants). CEA belongs to IgG supergene family protein and is not oncofetal protein. CA19-9 is synthesis in subjects with Le(a) or Le(b) type, but negative in Le(a- b-) type. Thus, CA19-9 is not available as TM in Le(a- b-) type. Many TMs can be classified in 3 types because cancer cell has the character of immature cells which composed of immature proteins or glycoproteins. (1) Oncofetal protein: AFP(fetal albumin), PTHrP(fetal PTH) (2) The immature isozyme type: increase of amylase(salivary type), CPK(brain type) and aldolase (muscle and brain type) (3) The immature protein in biosynthesis process: increase of precursor protein(prepro type or pro type) such as PIVKA-II(preprothrombin), ProGRP, TPA or CYFRA 21-1(pro-keratin?) and hormone precursor in hormone producing tumor.
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PMID:[Tumor marker--present and future]. 931 Dec 62