Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:4.1.2.13 (aldolase)
 3,461 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In 100 patients with histologically confirmed bronchogenic carcinoma, the reliability of serum aldolase determination as screening test for metastases in the liver has been investigated. Demonstration respectively exclusion of liver metastases was done by laparoscopy or occasionally by autopsy. In contrast to previous results, with the presently used, more reliable technique, the results were less satisfactory. True positive aldolase values as indicators of presence of liver metastases were observed in 72,7 percent of patients carrying those. In cases of chronic liver damage of other etiology, in general no elevated aldolase values were observed. The aldolase activity correlated with the amount of tumor tissue in the liver. An improvement of the enzymatic screening might be expected from additional determination of enzymes indicating cholostasis or from determination of liver-specific aldolase isoenzyme.
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PMID:[Relevance of serum aldolase for the detection of liver metastases of bronchial cancer--comparative enzymatic and endoscopy-autopsy studies]. 299 Jan 13

In 180 patients with histologically confirmed bronchial carcinoma exactitude of aldolase as a means for carrying out a screening test for metastases and relapses was checked. Enzyme activity was mostly normal in patients with limited extended local tumor growth including regional metastases as well as in tumour relapses. The group of patients with distant metastases, showed a distribution of increases and normal enzyme values which was equal; when differentiating further the majority of pathological aldolase values (79.4 per cent) was found in the group with liver metastases. We therefore regard as valuable the determination of serum aldolase when locking for liver metastases in confirmed bronchial carcinoma.
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PMID:[The value determination of serum aldolase for findings of metastases and relapses on bronchial carcinoma (author's transl)]. 721 Jul 39