Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:4.1.2.13 (aldolase)
 3,461 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

133 convalescents, formerly hospitalized for HBsAG-positive viral hepatitis and discharged still with HBsAG in the blood serum, and 982 persons (665 children and 317 adults) having contacts with the convalescents in families and organized groups have been subjected to many-year complex observation, including epidemiological, clinical and laboratory examinations. As a result, chronic HBsAG carriers with the antigen persisting in their blood for a year or longer have been found to be epidemiologically more dangerous in conditions of inartificial infection. Most often children, especially those with prolonged persistence of HBsAG in the blood accompanied by the development of chronic infectious process in the liver, are the source of hepatitis B infection. Among their contact the greatest number of persons (mostly children) with the manifest form of the infection and with certain signs of hepatitis B can be found. Of these signs, the presence of HBsAG in the blood serum and increased activity of fructose-1-phosphate aldolase are most frequently detected in persons having contacts with HGsaG carriers.
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PMID:[Epidemiologic significance of different categories of carriers of hepatitis B surface antigen (HBsAg). I. Role of reconvalescent HBsAg-positive viral hepatitis in the spread of infection]. 724 70

We reported a case of polymyositis manifested after beta-interferon therapy for chronic viral hepatitis type C. In November 1992, a 62-year-old female was diagnosed as having chronic viral hepatitis type C. In January 1993, she was treated with beta-interferon(total 2.52 x 10(8)IU). In March 1993, after the treatment, she noticed weakness and atrophy of her lower extremities. Neurological examination revealed proximal dominant muscle weakness and atrophy of the extremities. Increased levels of serum CK and aldolase were disclosed on admission. By needle EMG, a low voltage with short duration interference pattern was noted. February 7, by muscle biopsy of the right quadriceps, necrotic myofibers, marked variation in fiber diameter, stromal mononuclear cell infiltration, and endomysial fibrosis was detected. The immunological stain of infiltrating cells in the muscle fibers revealed CD4:CD8 ratio as 64:55, whereas in conventional polymyositis CD8 cells dominate CD4 cells. Diagnosis of polymyositis was made and oral prednisolone 60 mg a day was started. Her symptoms and signs improved gradually and she was discharged after 2 months. Many adverse effects due to immunological disturbances caused by interferon treatment have been reported, but polymyositis due to interferon has been very rare. When interferon will be prescribed, manifestation of polymyositis should be considered.
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PMID:[Polymyositis after interferon beta treatment of chronic hepatitis type C]. 868 84

The measurement of the plasma activities of glutamic-oxaloacetic and glutamic-pyruvic transaminases, aldolase, cholinesterase, and isocitric, lactic, and phosphogluconic dehydrogenases in random samples of blood was found to be of no value in the differential diagnosis of hepatitis, obstructive jaundice, hepatic cirrhosis, and neoplastic conditions involving the liver. Serial determinations of the enzyme activities provided useful information about the course of certain hepatic disorders, particularly acute viral hepatitis.
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PMID:Multiple plasma enzyme activities in liver disease. 1371 59