Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:4.1.2.13 (
aldolase
)
3,461
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
We examined developmental changes in the relative activities of three different isozyme systems:
aldolase
, enolase and phosphoglycerate mutase, in tissues of fetal mice with
trisomy
16 and of fetal euploid littermates. We wanted to determine whether morphological abnormalities such as reduced weight and size, which are generally observed in murine
trisomy
, are reflected at the molecular level. Following electrophoretic separation and subsequent measurement of relative activities of enolase isozymes in brain and phosphoglycerate mutase isozymes in heart, we found no significant differences between
trisomy
16 fetuses and their euploid littermates. Synthesis of liver-specific
aldolase
was, however, delayed in
trisomy
16 fetuses.
...
PMID:Influence of mouse trisomy 16 on expression of specific genes. 297 92
