Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:4.1.2.13 (aldolase)
 3,461 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Content of aldolase isoenzymes was reinvestigated in human and rat tissues by means of agar and starch gel electrophoresis. Heterogeneity of the A type aldolase is established and possible causes of formation of the multiple forms of the enzyme are discussed. The ratio of various fractions of aldolase A was different in erythrocytes of newborn and aldult persons. The patterns of the aldolase isozyme spectra were characterized in blood sera of newborns, in acute hepatitis and myocardial infarction.
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PMID:[Characteristics of the molecular diversities of human and rat aldolase via starch and agar gel electrophoresis]. 51 34

210 male patients hospitalized for cardiac rehabilitation have been studied. As a result of age matching the sample was reduced to 190 patients: 72 patients with myocardial infarction, 90 patients with functional cardiovascular diseases, and 28 patients with angina pectoris. At the beginning and at the end of the 4 to 6 week rehabilitation program total lipids, cholesterol, triglycerides, phosphatides, GOT, GPT, LDH, HBDH, cholinesterase, aldolase, blood sugar, creatinine, electrolytes, hemoglobin, erythrocytes, leukozytes, and catecholamines were measured. In addition to the statistical comparison of the three groups and their specific change patterns, effects of body weight reduction and improvement of physical fitness were analyzed. The decrease of lipids is especially associated with weight reduction, whereas the decrease of enzyme activity and electrolyte concentration is accompanied as well with weight reduction as with the improvement of physical fitness.
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PMID:[Biochemical measures in cardiac patients: an analysis of change during rehabilitation (author's transl)]. 69 75

Creatinphosphokinase (CPK) was elevated in sera of patients with malignant hyperthermia and in sera of some of their relatives. Only the MM-isoenzyme (but not the MB- or the BB-isoenzyme) could be detected by paperchromatographic analysis. In some of the patients elevation of muscle aldolase was also observed. Thus, the appearance of the BB-isoenzyme in sera of patients with malignant hyperthermia, as described by another group of investigators, was not confirmed. No specific screening method exists as yet to detect patients with a high risk of developing this often lethal reaction to anesthesia. However, in patients without muscle disease or trauma and without prior i.m. injections, myocardial infarction or major physical strain, elevation of CPK in serum should be interpreted as meaning that malignant hyperthermia may develop during anesthesia. The pathophysiology of malignant hyperthermia is discussed.
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PMID:[Malignant hyperthermia: attempt at an early diagnosis by means of determination of creatine phosphokinase (CPK) and its isoenzymes]. 99 19

A procedure is described for estimation of aldolase of the type A-a tissue-specific enzyme of myocardium--in blood serum under conditions of myocardial infarction. The rate of the enzymatic reaction was estimated by monitoring production of heptulose-1,7-diphosphate. Erythrose-4-phosphate and dihydroxyacetone phosphate were used as substrates of the reaction. High rates of the reaction product accumulation was observed if the compounds, shifting the reaction K'equi, were not added into the experimental samples. Sensitivity of the test was 3-fold increased due to modifications of the original method. Clinical experience with the test showed that activity of aldolase of the type A was distinctly higher in blood serum of patients with myocardium infarction as compared with the healthy donors or with the patients with ischemic heart disease.
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PMID:[Determination of aldolase A activity in the serum of patients with myocardial infarction]. 377 21

Data on changes in the blood activity of sorbit dehydrogenase (SDH) and fructose-1-phosphate aldolase (P-1-PA) in blood serum and the findings of radiohepatography in 224 patients with macrofocal and 120 patients with microfocal myocardial infarction are discussed. The studies were conducted in dynamics. Observations showed that SDH and P-1-PA activity grew in the acute period of mycrofocal myocardial infarction. The increase in enzyme activity was most marked in patients with cardiogenic shock. In patients with microfocal myocardial infarctions the increase in the activity of the enzymes studied was mainly encountered when there were signs of congestion in the liver. Radiohepatography revealed disorders of hepatic function in all patients with macrofocal myocardial infarction and in those patients with microfocal infarction who had congestion in the lijer. Changes in the radiogepatogram indices were most marked in patients with myocardial infarction attended by shock and congestion in the liver. The results of the study are evidence that simultaneous tests for SDH and P-1-PA activity in blood serum and radiohepatography give the fullest and most reliable information on the functional condition of the liver in patients with myocardial infarction.
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PMID:[Liver-specific enzymatic activity and radiohepatographic indices in evaluating the functional state of the liver in myocardial infarct]. 735 94

Aldolase (EC 4.1.2.13) plays an important role in glucose metabolism. Aldolase has a molecular weight of 160 kDa and has three isozymes, namely aldolase A, B and C. The enzyme is probably present in all cells; it occurs in particularly large quantities in the muscles, liver and brain. An increase in serum aldolase is found in myotonic muscular disease, such as progressive muscular dystrophy and polymyositis. The enzyme rises in myocardial infarction, reaches a maximum within 24-48 hours and returns to normal in the course of five days. In these muscular diseases, aldolase A isozyme is elevated. Aldolase activity, especially B isozyme, in serum rises to very high levels in acute hepatitis, but is slightly elevated in cirrhosis, chronic hepatitis and obstructive jaundice. Aldolase becomes elevated in serum with malignant tumors, and isozyme A is predominant in serum. Erythrocytes are also rich in aldolase, and the enzyme rises in hemolytic anemia.
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PMID:[Aldolase]. 1179 71