Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:4.1.2.13 (
aldolase
)
3,461
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Intracellular and serum activities of
aldolase
(
ALS
) were biochemically determined in lymphocyte subpopulations from normal subjects and patients with B-
chronic lymphocytic leukemia
(B-CLL). Aldolase activity was significantly lower in T cells of
CLL
than in normal T cells (2.9 +/- 1.5 vs. 4.7 +/- 2.1 Sigma Units (SU)/6 x 10(6) cells, p < 0.05). The
aldolase
activity also was significantly (p < 0.001) lower (3.1 +/- 1.9 SU/6 x 10(6) cells) in
CLL
B lymphocytes than in normal B lymphocytes (18.1 +/- 6.5 SU/6 x 10(6) cells). Moreover, the serum levels of
ALS
in all patients with B-
CLL
were higher than that in normal subjects (8.1 +/- 5.8 vs. 2.2 +/- 0.8 SU/ml, p < 0.02). Our findings demonstrate that T lymphocytes from patients with B-
CLL
display enzyme activity different from that of normal T cells. This may reflect the abnormal maturity of the residual T cell population in B-
CLL
.
...
PMID:Intracellular and serum levels of aldolase activity in B chronic lymphocytic leukemia. 147 33
