Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:4.1.2.13 (aldolase)
 3,461 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Sera from 82 patients with acute or chronic hepatitis and 40 chronic carriers of hepatitis B were examined by ELISA and immunoblotting for reactivity with the glycolytic enzyme aldolase. The results of the ELISA tests, expressed as a percentage of a positive control, were compared to those obtained with sera from 39 patients with rubella, 11 with cytomegalovirus infection and 74 healthy subjects. The ELISA reaction with sera, expressed as mean +/- standard deviation was, for 15 patients with hepatitis A, 58.3 +/- 20.5%; 15 with hepatitis B, 59.5 +/- 42.18; 23 with hepatitis non-A, non-B 51.1 +/- 34.4%; 11 with HBsAg positive chronic active hepatitis, 70.1 +/- 31.5%; and 17 with autoimmune chronic active hepatitis, 66.8 +/- 21.4%. All values were significantly (p less than 0.05-p - less than 0.001) higher than those obtained with sera from carriers of hepatitis B surface antigen, 25.6 +/- 27.2%; rubella, 21.1 +/- 20.0%; cytomegalovirus infection, 19.2 +/- 27.8%; or healthy subjects, 20.9 +/- 16.2%. In two randomly selected sera, reactivity with aldolase by ELISA was neutralized by absorption with the enzyme. Selected sera showing reactivity by ELISA reacted by immunoblotting with aldolase. The findings suggest that acute or chronic liver damage may provoke the production of autoantibodies to aldolase.
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PMID:Autoantibody to aldolase in acute and chronic hepatitis. 332 40

133 convalescents, formerly hospitalized for HBsAG-positive viral hepatitis and discharged still with HBsAG in the blood serum, and 982 persons (665 children and 317 adults) having contacts with the convalescents in families and organized groups have been subjected to many-year complex observation, including epidemiological, clinical and laboratory examinations. As a result, chronic HBsAG carriers with the antigen persisting in their blood for a year or longer have been found to be epidemiologically more dangerous in conditions of inartificial infection. Most often children, especially those with prolonged persistence of HBsAG in the blood accompanied by the development of chronic infectious process in the liver, are the source of hepatitis B infection. Among their contact the greatest number of persons (mostly children) with the manifest form of the infection and with certain signs of hepatitis B can be found. Of these signs, the presence of HBsAG in the blood serum and increased activity of fructose-1-phosphate aldolase are most frequently detected in persons having contacts with HGsaG carriers.
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PMID:[Epidemiologic significance of different categories of carriers of hepatitis B surface antigen (HBsAg). I. Role of reconvalescent HBsAg-positive viral hepatitis in the spread of infection]. 724 70