Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:4.1.2.13 (
aldolase
)
3,461
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
For the purpose of investigating events of energy metabolism in growing cartilages of human tubular and nontubular bones, measurements of creatine kinase (CK), lactate dehydrogenase (LDH), and
aldolase
of freshly excised cartilages in normal and pathologic conditions were performed. The level of cartilage CK of the normal phalanges (tubular bone) and exostosis was significantly less than those of the normal iliac bones (nontubular bone) and the
achondroplasia
tubular bone. A similar difference was also found between the tubular and the nontubular bone of an autopsy subject with
achondroplasia
. There was no statistical difference in the levels of LDH and
aldolase
in the cartilage between the tubular and the nontubular bone. These observations together with results obtained from iliac and limb cartilages of the newborn rat suggest the hypothesis that CK activity of cartilage of the tubular and the nontubular bone is different; cartilage of
achondroplasia
tubular bone has CK activity similar to that of normal nontubular bone cartilage.
...
PMID:Levels of creatine kinase activity in cartilage of tubular and nontubular bone in relation to pathogenesis of achondroplasia. 358 82
