Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:4.1.2.13 (aldolase)
 3,461 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

For the purpose of investigating events of energy metabolism in growing cartilages of human tubular and nontubular bones, measurements of creatine kinase (CK), lactate dehydrogenase (LDH), and aldolase of freshly excised cartilages in normal and pathologic conditions were performed. The level of cartilage CK of the normal phalanges (tubular bone) and exostosis was significantly less than those of the normal iliac bones (nontubular bone) and the achondroplasia tubular bone. A similar difference was also found between the tubular and the nontubular bone of an autopsy subject with achondroplasia. There was no statistical difference in the levels of LDH and aldolase in the cartilage between the tubular and the nontubular bone. These observations together with results obtained from iliac and limb cartilages of the newborn rat suggest the hypothesis that CK activity of cartilage of the tubular and the nontubular bone is different; cartilage of achondroplasia tubular bone has CK activity similar to that of normal nontubular bone cartilage.
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PMID:Levels of creatine kinase activity in cartilage of tubular and nontubular bone in relation to pathogenesis of achondroplasia. 358 82

Vitamin D is responsible, through the actions of its metabolite, 1 alpha,25-dihydroxyvitamin D3 [1 alpha,25-(OH)2D3], for the generation of a wide array of biological responses, particularly in the intestine, kidney, and bone. 1 alpha,25-(OH)2D3 is known to interact with its nuclear receptor to mediate the regulation of gene transcription. Although many genes and gene products have been shown to be regulated by 1 alpha,25-(OH)2D3 (e.g. calbindin-D28K in the intestine and kidney; collagen, osteocalcin,and osteopontin in bone), their recognition has been largely the result of empirical testing. In this report we have used subtractive hybridization analysis of complementary DNA libraries prepared from messenger RNA (mRNA) isolated from the intestine and kidney of vitamin D-replete or vitamin D-deficient chicks to identify genes for novel proteins whose steady state mRNA levels are regulated by dietary vitamin D status. In the kidney we observed the down-regulated expression of at least seven mitochondrially encoded transcripts and the up-regulated expression of five nuclear encoded genes, two of which are metallothionein and the beta-subunit of aldolase. In the intestine, six mitochondrially encoded transcripts are up-regulated, and seven nuclear encoded transcripts were either up- or down-regulated. Thus, in addition to identifying new nuclear encoded genes whose mRNAs are regulated by vitamin D status, our approach has demonstrated the tissue-specific regulation of mitochondrial gene expression in the intestine and kidney.
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PMID:Tissue-specific regulation by vitamin D status of nuclear and mitochondrial gene expression in kidney and intestine. 758 3