Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:4.1.1.6 (CAD)
 4,420 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The results of rest blood-equilibrium radionuclide ventriculography (RVG) and of coronary arteriography were reviewed together. In 12 angiographically proved CAD patients, Fourier analysis correctly diagnosed 11, with an accuracy of 83.33% in localization 9 patients with myocardial infarction showed "empty" area in phase images. The phase analysis in RVG was considered a sensitive and accurate method in evaluating patients of CAD.
Zhonghua Xin Xue Guan Bing Za Zhi 1990 Jun
PMID:[Comparative study of coronary artery disease using Fourier analysis in radionuclide ventriculography and coronary arteriography]. 208 72

Sixty patients of CAD were studied with 24 and 48 hours ambulatory electrocardiogram monitoring. The day-to-day natural variances of transient myocardial ischemia in this group were analysed. The ranges of variation of myocardial ischemia based on a 95% confidence interval were confirmed. The results showed that the day-to-day variances of ischemia between the different days were: (1) 43% in number of ischemia episodes, (2) 76% in duration, (3) 53% in integration, and (4) 48% in maximal degree of ST depression.
Zhonghua Xin Xue Guan Bing Za Zhi 1990 Dec
PMID:[The natural variance of transient myocardial ischemia in coronary artery patients]. 209 53

The levels of total cholesterol, triglyceride, LDL-C, HDL-C, apolipoprotein A1 and apolipoprotein B in the serum were measured in a selected series of 100 CAD patients (77 men and 23 women) who underwent coronary angiography and 141 non-CAD controls. Mean values of those variables differed significantly between the CAD and non-CAD groups matched in age, body weight, hypertension and smoking. There are significant difference in apolipoproteins A1, B and the ratio of apolipoprotein B to A1 between angina and myocardial infarction groups. Using stratified and multivariate stepwise regression analysis, it was shown that the apo A1, apoB/apoA1 are more sensitive and specific than the ordinary indices (e.g. total cholesterol, triglycerides, LDL-C and HDL-C) in estimating the degree of coronary artery stenosis and the differentiation of CAD from other diseases.
Zhonghua Xin Xue Guan Bing Za Zhi 1990 Aug
PMID:[Serum apolipoprotein AI, B levels in patients with coronary diseases]. 212 69

Staphylococcal nuclease domain-containing protein 1 (SND1) has been reported as an oncoprotein in a variety of cancers involving multiple processes, including proliferation, angiogenesis, and metastasis. However, the mechanisms underlying metastasis remain largely unknown. Herein, by using the ovarian cancer cell line SKOV3, which has high metastasis ability, we showed that loss-of-function of SND1 dramatically suppressed the invasion and migration of SKOV3 cells. We then performed gene expression profiles and further verified (by use of quantitative PCR and Western blot analysis) that loss-of-function of SND1 resulted in up-regulation of epithelial markers, such as epithelial cadherin and claudin 1, and down-regulation of mesenchymal markers, including neural cadherin and vimentin. Moreover, we illustrated that SLUG, a key transcription factor implicated in epithelial-mesenchymal transition and metastasis, acts as an essential effector of the SND1-promoted epithelial-mesenchymal transition process via regulating N-CAD and VIM expression (or E-CAD and CLDN1). The underlying molecular mechanisms illustrated that SND1 regulates the gene transcriptional activation of SLUG by increasing chromatin accessibility through the recruitment of the acetyltransferases GCN5 and CBP/p300 to the SLUG promoter proximal region. Overall, SND1 was identified as a novel upstream regulator of SLUG, which plays important roles in regulating the E-CAD/N-CAD expression switch.-Xin, L., Zhao, R., Lei, J., Song, J., Yu, L., Gao, R., Ha, C., Ren, Y., Liu, X., Liu, Y., Yao, Z., Yang, J. SND1 acts upstream of SLUG to regulate the epithelial-mesenchymal transition (EMT) in SKOV3 cells.
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PMID:SND1 acts upstream of SLUG to regulate the epithelial-mesenchymal transition (EMT) in SKOV3 cells. 3050 25