Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:4.1.1.6 (CAD)
 4,420 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The attempt was performed to isolate desialylated low density lipoproteins (LDL) from the blood of healthy subjects and patients with coronary heart disease by affinity chromatography with immobilized agglutinin of Ricinus communis, a lectin that interacts specifically with galactose residues. A part of LDL was bound to sorbent and could be replaced by galactose but not other saccharide constituents of the LDL molecule. Bound LDL subfraction had a 2-3-fold lower content of desialylated LDL in CAD patients was about 3-fold higher than in healthy subjects. Desialylated LDL induced a 2- to 4-fold increase of total cholesterol content in cultured human aortic intimal cells, whereas unbound LDL had no effect on intracellular cholesterol level. It is assumed that the subfraction of desialylated LDL may be responsible for the atherogenic properties of LDL in CAD patients.
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PMID:[Isolation of desialylated low density lipoproteins from the blood of patients with ischemic heart disease by affinity chromatography]. 208 59

Mediterranean spotted fever develops from an infection with Rickettsia conorii, an obligate intracellular, Gram-negative, endotheliotropic, and tick-transmitted bacterial pathogen, and is an acute, febrile illness that can progress to life-threatening complications if not diagnosed and treated early with effective antibiotics. Despite significant morbidity and mortality, little is known about changes in gene expression that determine the host responses during in vivo infection. We have investigated the transcriptional landscape of host lungs as a prominently affected organ system in an established murine model of infection by RNA-sequencing. Ingenuity pathway analysis resulted in the identification of 1332 differentially expressed genes and 292 upstream regulators. Notably, genes encoding for ubiquitin D, aconitate decarboxylase, antimicrobial peptides, calgranulins, cytokines and chemokines, and guanylate binding proteins were highly up-regulated, whereas those involved in hemoglobin biosynthesis and heme homeostasis were significantly down-regulated. Amongst response regulators, nucleotide-binding oligomerization domain-containing protein 2 and killer cell lectin-like receptors were differentially expressed, and gene clustering revealed eukaryotic initiation factor-2, oxidative phosphorylation, and ubiquitination as the predominantly activated biological pathways. Collectively, this first global transcriptomic profiling has identified R. conorii-induced regulation of novel genes and pathways in the host lungs, further in-depth investigation of which will strengthen our understanding of the pathogenesis of human rickettsioses.
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PMID:Global Transcriptomic Profiling of Pulmonary Gene Expression in an Experimental Murine Model of Rickettsia conorii Infection. 3085 42