Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:4.1.1.6 (
CAD
)
4,420
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
This cross-sectional study tested the hypothesis that decreased serum levels of
tetranectin
(TN), a regulator of the fibrinolysis and proteolytic system, is associated with the presence and severity of
CAD
. We conducted a systematic serological and immunohistochemical (IHC) analysis to respectively compare the TN levels in serum and artery samples in
CAD
patients and healthy controls. Our results showed that serum levels of TN were significantly lower in patients with
CAD
than in healthy controls. Further analysis via trend tests revealed that serum TN levels correlated with the number of diseased arteries. Besides, the multivariate logistic regression model revealed TN as an independent factor associated with the presence of
CAD
. Additionally, IHC analysis showed that TN expression was significantly higher in atherosclerotic arteries as compared to healthy control tissues. In conclusion, our study suggests that increased serum TN level is associated with the presence and severity of diseased coronary arteries in patients with stable
CAD
.
...
PMID:Tetranectin as a Potential Biomarker for Stable Coronary Artery Disease. 2662 97
