Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:4.1.1.6 (CAD)
 4,420 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The potential of carbon nanotubes for the solid phase extraction of parabens in cosmetic products and the detection using a corona-charged aerosol detector (C-CAD) is presented in this work. The analytical procedure is based on a conventional solid phase extraction step for which 20mg of multi-walled carbon nanotubes were packed in a 3-mL commercial SPE cartridge. Methylparaben, ethylparaben, propylparaben and butylparaben were thus isolated and preconcentrated from the pre-treated samples and subsequently separated on a RP-C18 column using acetonitrile:water, 50:50 (v/v) as mobile phase. The analytical signals for the individual parabens were obtained using C-CAD. The experimental variables affecting the extraction procedure and the instrumental detection have been deeply studied. Limits of detection were in the range of 0.5-2.1mgL(-1), while the linear range was extended up to 400mgL(-1). The average precision of the method varied between 3.3-3.8% (repeatability) and 4.3-7.6% (reproducibility). Finally, the optimized procedure was applied to the determination of the target preservatives in a variety of cosmetic products with satisfactory results.
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PMID:Determination of parabens in cosmetic products using multi-walled carbon nanotubes as solid phase extraction sorbent and corona-charged aerosol detection system. 1993 86