Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:4.1.1.6 (
CAD
)
4,420
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
To find a new locus that confers significant susceptibility to
CAD
in Chinese Han population, a genome-wide association study in 200 "extreme individuals" from a Shandong cohort and a pathway-based candidate gene study from a Shanghai cohort (293
CAD
/293 controls) were simultaneously performed. Amongst them, 13 SNPs associated with
CAD
were selected to conduct validation and replication studies in additional 3363
CAD
patients and 3148 controls. A novel locus rs700926 in
natriuretic peptide receptor C
(
NPR-C
) was identified in Shandong and Hubei cohorts. Then rs700926 and other nine tag SNPs were genotyped in four geographically different populations (Shandong, Shaanxi, Hubei and Sichuan cohorts), and 6 SNPs (rs700926, rs1833529, rs2270915, rs17541471, rs3792758 and rs696831) showed stronger association with
CAD
, regardless of single or combined analysis. We further genotyped rs2270915 and 10 additional tag SNPs in a central China cohort and identified rs12697273 and rs10066436 as the loci associated with
CAD
. All these positive associations remained significant after adjustment for traditional risk factors of
CAD
.
NPR-C
gene SNPs significantly contribute to
CAD
susceptibility in the Chinese Han population.
...
PMID:NPR-C gene polymorphism is associated with increased susceptibility to coronary artery disease in Chinese Han population: a multicenter study. 2719 Dec 71
