Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:4.1.1.6 (
CAD
)
4,420
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The trifunctional enzyme
CAD
catalyzes the first three steps of pyrimidine biosynthesis. By using fluorescence in situ hybridization we have localized the Chinese hamster
CAD
gene on chromosome 7q11-q13 of diploid fibroblasts. Other genes previously assigned to chromosome 7 include
acid phosphatase
-1, the M2 subunit of ribonucleotide reductase and ornithine decarboxylase. These genes are also syntenic with
CAD
on human chromosome 2p. We have then mapped
CAD
on the pericentromeric region of two different rearranged chromosomes (Z8p and R2q) in a cell line derived from Chinese hamster ovary. The presence of
CAD
on Z8 and R2 indicates that they derive from rearrangements involving chromosome 7.
...
PMID:Localization of the Chinese hamster CAD gene reveals homology between human chromosome 2p and Chinese hamster 7q. 810 Aug 5
