Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:4.1.1.6 (CAD)
 4,420 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Of the 10 chronic haemodialysis patients whose serum TnT levels exceeded the threshold value of 0.1 microg.L(-1) at entry into the study, four were dead at 1 year and three others had a diagnosis of CAD. Of the 20 chronic haemodialysis patients with normal serum TnT levels at entry, one died and none had CAD. All five deaths were cardiac related, either arising from acute myocardial infarction or by sudden death. When serum TnT levels were compared with accepted predictors of death in chronic haemodialysis patients, such as serum creatinine, serum albumin and haematocrit, in the present study serum TnT proved to be more accurate and had excellent sensitivity and specificity. Serum TnT was also superior to serum TnI, which proved to be no more discriminating than the non-specific muscle marker, aldolase.
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PMID:Troponin T, a predictor of death in chronic haemodialysis patients. 985 37

Well-defined lactose-containing glycopolymer has been synthesized by reversible addition-fragmentation chain transfer (RAFT) polymerization with (4-cyanopentanoic acid)-4- dithiobenozoate (CAD) as chain transfer agent. The glycopolymer was introduced onto the exterior surfaces of the bovine serum albumin (BSA) imprinted polymer beads by grafting copolymerization with methyl methacrylate and ethylene glycol dimethacrylate. After alcoholysis, the hydrophilic lactose residues of glycopolymer will stretched on the surface of the MIP beads and then the hydrophilicity of the surface will be enhanced. Rebinding test shows that the glycopolymer hydrophilic modified BSA imprinted polymer presents higher performance selectivity than that of unmodified one, which means that the hydrophobic-hydrophilic balance of the imprinted polymer surface is in favor of the improvement of specific recognition property of the material.
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PMID:Surface hydrophilic modification with well-defined glycopolymer for protein imprinting matrix. 2123 78

Doxorubicin (DOX) is one of the most effective anti-cancer drugs, but its therapeutic efficacy is greatly hampered by its non-specific delivery to the target tissue and the resultant cumulative cardiotoxicity and nephrotoxicity. In order to overcome this limitation, we prepared a folate-bovine serum albumin (BSA)-cis-aconitic anhydride-doxorubicin prodrug, denoted by FA-BSA-CAD. A tumor-targeting agent, folic acid, was linked to BSA to increase the selective targeting ability of the conjugate. BSA provided a large number of reactive sites for multivalent coupling of bioactive molecules and improved the water-solubility of the prodrug. DOX is attached to the BSA via a pH-sensitive linker, cis-aconitic anhydride, which hydrolyzes in the acidic lysosomal environment to allow pH-responsive release of DOX. The in vitro results demonstrate a pH-responsive drug release under different pH conditions. Furthermore, the targeting ability and therapeutic efficacy of the prodrug were assessed both in vitro and in vivo. The results demonstrate that FA-BSA-CAD prodrug selectively targeted tumor cells and tissue, with associated reduction in non-specific toxicity to the normal cells. More importantly, the therapeutic efficacy of the prodrug for FA-positive tumors increased compared to the non-conjuagted DOX.
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PMID:A pH-sensitive doxorubicin prodrug based on folate-conjugated BSA for tumor-targeted drug delivery. 2337 5