Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:4.1.1.6 (
CAD
)
4,420
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The identification of mutations in the haemochromatosis gene (
HFE
) (C282Y and H63D) provides the unique opportunity to test whether genetic variants that are associated with tissue iron accumulation may influence the risk of coronary atherosclerosis. To this aim the prevalence of C282Y and H63D mutations was determined in 174 patients with angiographically documented
CAD
(>50% stenosis) and history of MI, 187 healthy free-living individuals and 142 blood donors. C282Y and H63D mutations were not found to be more frequent in coronary patients as compared to controls. Moreover, these
HFE
variants were unrelated to the severity of coronary atherosclerosis. These findings did not provide evidence of an association between
HFE
mutations and the presence of coronary atherosclerosis or its major ischaemic complications, thus indicating that
HFE
mutations are poor genetic markers of coronary risk.
...
PMID:Haemochromatosis gene mutations and risk of coronary artery disease. 1085 1
