Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:4.1.1.6 (CAD)
 4,420 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Survivors of traumatic spinal cord injury (tSCI) have intense healthcare needs during acute and rehabilitation care and often through the rest of life. To prepare for a growing and aging population, simulation modeling was used to forecast the change in healthcare financial resources and long-term patient outcomes between 2012 and 2032. The model was developed with data from acute and rehabilitation care facilities across Canada participating in the Access to Care and Timing project. Future population and tSCI incidence for 2012 and 2032 were predicted with data from Statistics Canada and the Canadian Institute for Health Information. The projected tSCI incidence for 2012 was validated with actual data from the Rick Hansen SCI Registry of the participating facilities. Using a medium growth scenario, in 2032, the projected median age of persons with tSCI is 57 and persons 61 and older will account for 46% of injuries. Admissions to acute and rehabilitation facilities in 2032 were projected to increase by 31% and 25%, respectively. Because of the demographic shift to an older population, an increase in total population life expectancy with tSCI of 13% was observed despite a 22% increase in total life years lost to tSCI between 2012 and 2032. Care cost increased 54%, and rest of life cost increased 37% in 2032, translating to an additional CAD $16.4 million. With the demographics and management of tSCI changing with an aging population, accurate projections for the increased demand on resources will be critical for decision makers when planning the delivery of healthcare after tSCI.
 ...
PMID:Forecasting Financial Resources for Future Traumatic Spinal Cord Injury Care Using Simulation Modeling. 2859 15

Rationale: Recovery of autonomy, in paralyzed/with severe disabilities patients, is one of the most difficult challenges for rehabilitation. Thus, an appropriate wheelchair is essential for this kind of people, both in daily lives, including work and social participation, and for quality of life (QoL). Objective: The purpose of the study is to achieve a consistent improvement to the actual models of wheelchairs followed by validation through clinical trial of the optimized prototype, in order to enhance the users' autonomy and QoL. Material and Results: In the research activities and for establishing constructive and optimized functional solutions will be used, simulation of system operation techniques, based on software packages and Computer-Aided Design/ Engineering (CAD/ CAE) systems. Validation, of the optimized wheelchair prototype, through clinical trial, requires a prospective study. The study will include a group of 30 patients, who will be investigated for a one-month period. The patients will complete, at the end of the study, a standardized questionnaire containing generic data and many items referring to the optimized wheelchair functions and to the autonomy of the users including in relation to their own expectations. We will also use the quantified evaluation scale of QoL, Wheelchair Outcome Measure (WhOM) and a Falls Concern Scale for people with Spinal Cord Injury (SCI-FCS). Discussion: The wheelchair particularities that we pursue, and which are distinguished from the other models, is the fact that the wheelchair is powered, pliable and allows verticalization, hopefully at a price comparable or even lower than the current state of the art models (but none of them succeeded by now to fulfil all this three basic functions on a single "all in one" such device). Hence, if our optimized prototype will achieve technical and clinical validation, this will result in a significant enhancement of autonomy and QoL for the users.
 ...
PMID:Assumptions and conceptual contributions to improve the global assistive performance of actual wheelchairs, in order to enhance the users' autonomy and quality of life. 3180 94