Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:4.1.1.49 (phosphoenolpyruvate carboxykinase)
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Human Gene/Protein
PEPCK 12.7
Hepatic nuclear factor 4 alpha 12.7
phosphoenolpyruvate carboxykinase 12.7
phosphoenolpyruvate carboxylase 12.6
PEPCK-M 12.3
PEPCK-C 12.0
zinc finger homeodomain protein 11.7
PCK1 11.6
PCK2 11.5
NADP-malic enzyme 11.4
TCDD-inducible poly(ADP-ribose) polymerase 11.2
HIST1H2BM 11.2
RNA-binding protein 6 11.2
NAD-malic enzyme 11.1
NAD-ME 11.1
NADP-ME 10.8
AREBP 10.7
MRP-S9 10.7
pyruvate carboxylase, mitochondrial 10.7
cartilage intermediate layer protein 2 10.7
G6Pase 10.7
TSE1 10.5
cytochrome c-1 10.4
pyruvate carboxylase 10.4
CAMKK 10.2
CPS1 protein 10.2
Glutamic dehydrogenase 10.2
GAPT 10.2
glucose-6-phosphatase 10.1
carboxylating 10.1
fructose-bisphosphatase 10.1
GK5 9.9
APC2 protein 9.9
dihydrolipoamide S-succinyltransferase 9.9
pck2 9.8
fructose 1,6-bisphosphatase 9.8
PDE3B protein 9.7
Forkhead/winged helix transcription factor 9.7
phosphoenolpyruvate carboxykinase 2 9.7
glycerokinase 9.6
SVOPL 9.6
Tissue-specific extinguisher 1 9.6
PLD5 9.6
Fructose-bisphosphate aldolase 9.6
NADP-dependent malic enzyme 9.5
fructose-1,6-bisphosphatase 9.5
pyruvate kinase L 9.5
CRTC2 9.4
Fructose 1,6-bisphosphatase 9.4
Pyruvate carboxylase 9.4
Malic enzyme 9.3
TCF7L2 protein 9.3
phosphorylase, glycogen 9.3
1-acylglycerol-3-phosphate O-acyltransferase 2 9.3
NAD-dependent glyceraldehyde-3-phosphate dehydrogenase 9.2
ZFP91 9.2
carbamoylphosphate synthetase I 9.2
RFWD2 9.2
ZHX3 9.2
TMED2 9.2
liver glycogen synthase 9.1
ME5 9.0
AdPLA 9.0
S171 9.0
TRB1 9.0
FBPase 9.0
FBP1 9.0
IDP 9.0
fructose-1,6-bisphosphatase 1 9.0
glucokinase 8.9
endosomal adaptor protein 8.9
constitutive heat shock protein 70 8.9
succinate dehydrogenase flavoprotein subunit 8.9
ESA1 8.9
pyruvate kinase 8.9
BHLHE40 8.9
serine dehydratase 8.8
glycine dehydrogenase 8.8
FEEL-1 8.8
CAT5 8.8
more...
Disease
Glucagon resistance 10.7
Avian reticuloendotheliosis 10.4
ALAD deficiency 8.8
Brain mass 8.6
Fasting hypoglycemia 8.0
Biotin deficiency 7.8
Neonatal respiratory distress syndrome 7.7
CPS deficiency 7.5
Paxton 7.4
coenurosis 7.2
Hers 7.1
porcine stress syndrome 6.9
Benson 6.6
Mohr 6.6
PNP deficiency 6.5
disorders of amino acid metabolism 6.5
MODY1 6.3
MODY2 6.2
PDH deficiency 6.2
diphyllobothriasis 6.0
diabetic hyperglycemia 5.9
AD1 5.8
orotic aciduria 5.8
hepatic porphyria 5.8
FAS 5.7
hyperglycemia 5.6
MODY 5.6
Jejunum 5.6
postmaturity 5.5
glucose intolerance 5.5
lymphoblastoma 5.4
CAM 5.4
hyperinsulinemia 5.4
AD2 5.3
potassium deficiency 5.2
Hymenolepis 5.2
LCS 5.1
kidney hypertrophy 5.1
LCAT deficiency 5.0
KMS 5.0
Buchanan 5.0
hypoglycemia 4.9
vitamin B6 deficiency 4.9
prolonged pregnancy 4.9
Simpson-Golabi-Behmel syndrome 4.9
KMS 4.8
LIP 4.8
tapeworm 4.8
wasting syndrome 4.8
ketosis 4.8
Enzyme inhibition 4.7
type 2 diabetes 4.7
idiopathic thrombocytopenic purpura 4.7
fatty liver 4.7
overnutrition 4.7
ACS1 4.6
endotoxic shock 4.6
Adenovirus 4.6
PRS 4.6
PER 4.6
vitamin A deficiency 4.6
beriberi 4.6
RDP 4.5
Spraying 4.5
chlorosis 4.4
lipodystrophy 4.4
AIN 4.4
Copper deficiency 4.4
hepatic neoplasm 4.3
HEP 4.3
HTL 4.2
hepatocellular carcinoma 4.2
APOB 4.2
DIG 4.1
fascioliasis 4.1
nutritional disorder 4.1
AOA 4.1
thiamine deficiency 4.1
FDH 4.0
PND 4.0
more...
Symptom
Tissue anoxia 10.4
loss of equilibrium 5.6
starvation 5.1
inanition 4.9
blackout 3.9
acidity 3.8
Decreased activity 3.7
Anoxia 3.6
acute stress 3.2
cachexia 3.1
hepatomegaly 2.8
polyuria 2.7
emaciation 2.7
polydipsia 2.6
exhaustion 2.3
tense 1.7
splenomegaly 1.1
anorexia 1.0
hyperoxia 0.4
thinning 0.3
hunger 0.3
fatigue -0.3
dizziness -0.5
sleepiness -0.9
overweight -0.9
stigma -1.0
hypothermia -1.3
tremor -1.4
discomfort -1.7
cough -1.8
discomfort -1.8
anesthesia -2.0
vomiting -2.2
diarrhea -3.1
pain -4.3
Drug
Sulfopyruvate 10.4
Phenylphosphate 9.6
Cottonseed oil 8.9
p-Chlorophenyl 8.8
Citrus unshiu peel 8.7
Posilac 8.4
1-Deoxynojirimycin 8.1
Aspartic Acid 7.6
Sodium sulfate 7.5
Nipradilol 6.8
Vanilla 6.6
Pyridoxamine 6.6
Calan 6.5
Rosiglitazone 6.4
Glucagon 6.3
Fructose 6.1
Trilostane 6.0
Ipriflavone 5.8
Troglitazone 5.7
Myricetin 5.5
Pentostam 5.4
CAM 5.3
Carbenoxolone 5.2
Glycerol 5.1
NADH 5.0
Liraglutide 5.0
Ammonium chloride 4.9
Aloe 4.8
Rasburicase 4.8
citric acid 4.8
CDX 4.7
Asparaginase 4.7
Isoptin 4.7
CER 4.6
Exenatide 4.4
Gemfibrozil 4.4
Colombo 4.4
Flavin 4.3
Enrofloxacin 4.3
Diurnal 4.3
CDX 4.3
Alanine 4.1
CoCl2 4.0
CoCl2 4.0
Aminoguanidine 4.0
Growth hormone 4.0
Scopolamine 4.0
beta-Galactosidase 4.0
Growth hormone 4.0
DEX 3.9
Valsartan 3.9
Emodin 3.9
Monensin 3.8
Glutamic acid 3.7
Citric acid 3.7
DNase I 3.7
DMI 3.7
Orphan 3.7
Indocyanine green 3.6
Salicylate 3.6
Clofibrate 3.6
Emodin 3.6
Dasatinib 3.5
Vitamin A 3.5
Vitamin B 3.4
Arsenic trioxide 3.4
Forskolin 3.4
Gel 3.3
Glycyrrhiza 3.3
Carotenoid 3.2
OTC 3.2
Capsicum 3.2
Riboflavin 3.1
CDP 3.1
TEL 3.1
AGG 3.1
TAT 3.1
Leaf 3.1
Kenyan 3.0
NH3 3.0
more...
Enzyme
phosphoenolpyruvate carboxykinase 12.7
phosphoenolpyruvate carboxykinase 12.7
phosphoenolpyruvate carboxykinase 12.7
phosphoenolpyruvate carboxylase 12.5
EC 1.3.1.37 12.2
PEP phosphatase 12.1
EC 4.1.1.40 11.7
L-idonate dehydrogenase 11.7
PPDK 11.2
CimA 10.4
malyl-CoA lyase 10.4
pyruvate carboxylase 10.4
phosphoenolpyruvate synthase 10.3
oxaloacetate decarboxylase 10.3
glucose-6-phosphatase 10.1
fructose 1,6-bisphosphatase 9.7
EC 1.1.1.82 9.7
malate thiokinase 9.4
nucleotide 3'-pyrophosphokinase 9.3
UGT85B1 9.3
EC 1.1.1.38 9.3
triokinase 9.2
glycine dehydrogenase 9.0
glycine dehydrogenase 9.0
rubisco 9.0
glucokinase 9.0
aldose-6-phosphate reductase 8.9
pyruvate kinase 8.9
EC 1.1.1.40 8.9
citrate cleavage enzyme 8.7
glutaminase II 8.7
isocitrate lyase 8.6
sucrose-phosphatase 8.6
malate dehydrogenase 8.5
propionate kinase 8.4
glycine dehydrogenase 8.4
carbamoylphosphate synthetase 8.4
acetate kinase 8.3
EC 2.6.1.4 8.2
malate synthase 8.2
GapB 8.2
tyrosine aminotransferase 8.1
hydroxypyruvate reductase 8.1
pyruvate:ferredoxin oxidoreductase 8.1
glycerol kinase 8.0
pyruvate formate-lyase 8.0
fumarase 8.0
fumarate reductase 8.0
citrate lyase 7.9
hydroxypyruvate reductase 7.9
AIR synthetase 7.9
glycolate dehydrogenase 7.9
trehalose phosphate synthase 7.8
6-phosphofructo-2-kinase 7.8
glutamate synthase 7.8
glycine decarboxylase 7.8
glutamate synthase 7.7
diaminopimelate dehydrogenase 7.7
SBPase 7.7
glycerate kinase 7.7
citramalate synthase 7.7
propionyl-CoA carboxylase 7.6
ferric chelate reductase 7.6
acetyl-CoA synthetase 7.6
glutamate synthase 7.6
12-oxophytodienoate reductase 7.6
phosphofructokinase 7.6
carboxypeptidase S 7.6
transcarboxylase 7.5
diaminopimelate decarboxylase 7.5
dihydroxyacetone kinase 7.5
aspartokinase 7.4
NADPH:quinone oxidoreductase 7.4
glycerol 3-phosphate dehydrogenase 7.4
EC 1.1.1.39 7.4
isocitrate dehydrogenase 7.4
propionyl-CoA carboxylase 7.3
ornithine cyclodeaminase 7.3
argininosuccinate synthetase 7.3
desulfinase 7.2
more...
Compound
Ethyl bromopyruvate 12.7
Glyoxal bisulfite 12.7
Perfluorosuccinate 12.7
Linderane 12.7
Diethyl oxaloacetate 11.7
Potassium sulfate 10.4
Potassium sulfate 10.4
Gentianine 10.2
3-MPA 9.9
Hydrazine sulfate 9.8
o-Iodosobenzoate 9.7
Phenylphosphate 9.6
3-sulfopyruvate 9.6
Saponarin 9.6
N-formimino-l-glutamate 9.4
oxalacetate 9.4
Butylamine 9.0
Ribose 5-phosphate 8.9
IDP 8.9
PEP 8.8
Swertiamarin 8.7
GW 9662 8.6
Malate 8.6
Amarogentin 8.5
1-Anilinonaphthalene 8.3
Trehalose-6-phosphate 8.1
Aminoimidazole 7.9
Glucose 6-phosphate 7.9
6-phosphogluconolactone 7.9
dCDP 7.7
Syringaldehyde 7.6
malic acid 7.5
Ribulose 7.5
Pyruvate kinase 7.4
mercaptopyruvate 7.4
propionyl-coenzyme A 7.3
Ectoine 7.3
dGDP 7.3
Sodium sulfate 7.3
Diosmin 7.3
Bromelia 7.2
Nialamide 7.2
4-fluorophenylalanine 7.2
Quinolinic acid 7.1
Myricitrin 7.1
glucose-6-phosphate 7.1
Phenelzine 7.1
Glyoxylate 7.0
Phenelzine 7.0
6-fluorotryptophan 7.0
2,3-dimercapto-1-propanol 6.9
2,3-dimercapto-1-propanol 6.9
Beclomethasone 6.9
Pyruvate 6.9
Eupatilin 6.9
malic acid 6.9
malic acid 6.9
malic acid 6.9
Triamcinolone 6.8
2-phosphoglycerate 6.8
ADP-glucose 6.7
Azocoll 6.6
thieno[2,3-b]pyridine 6.6
Glabridin 6.6
CONV 6.6
Acetyl phosphate 6.6
acetyl-CoA 6.6
Dibutyryl cyclic AMP 6.6
2-Oxoglutarate 6.6
Dibutyryl cyclic AMP 6.6
Pyridoxamine 6.5
ITP 6.5
NPR 6.5
2-amino-2-methyl-1-propanol 6.5
pentose 6.5
pentose 6.5
Glycerate 6.5
2-decenoic acid 6.4
D-xylulose-5-phosphate 6.4
Succinyl-CoA 6.4
more...