Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:4.1.1.49 (phosphoenolpyruvate carboxykinase)
4,654 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
phosphoenolpyruvate carboxykinase 2817
phosphoenolpyruvate carboxylase 1344
insulin 1043
PEPCK 570
glucose-6-phosphatase 505
pyruvate kinase 357
Mol 352
Sep 329
pyruvate carboxylase 279
ATP 274
glucagon 259
CO2 246
malate dehydrogenase 221
glucokinase 207
phosphatase 147
AMP 145
G6Pase 130
NADP 121
PEP 110
NAD 110
lactate dehydrogenase 108
fructose-1,6-bisphosphatase 103
NADH 103
ADP 103
GTP 98
glucocorticoid receptor 93
phosphofructokinase 91
NADP-malic enzyme 91
fatty acid synthase 89
peroxisome proliferator-activated receptor 89
glucose transporter 88
hexokinase 87
aspartate aminotransferase 86
Bot 86
PCK1 86
insulin receptor 81
glutamate dehydrogenase 80
leptin 80
IRS-1 77
glutamine synthetase 77
citrate synthase 73
NADPH 73
glycogen synthase 67
glucose-6-phosphate dehydrogenase 66
rhabdomyosarcoma 63
AMP-activated protein kinase 62
growth hormone 62
PEPCK-C 60
isocitrate dehydrogenase 58
alanine aminotransferase 57
AMPK 56
polypeptide 56
PGC 55
pyruvate dehydrogenase 55
TCA 54
NMR 54
TAT 52
albumin 52
protein kinase B 51
acetyl-CoA carboxylase 50
AKT 50
carbonic anhydrase 49
glycogen phosphorylase 49
peroxisome proliferator-activated receptor gamma 49
catalase 49
NAD-malic enzyme 47
proximal tubule 46
fructose 1,6-bisphosphatase 46
GDP 43
superoxide dismutase 43
EBP 40
CREB 40
ATPase 40
TNF 39
fused 39
epididymal 38
lipoprotein lipase 38
fumarase 34
nuclear receptor 34
glutaminase 34
more...
Disease
diabetes 350
hyperglycemia 216
type 2 diabetes 216
hepatocellular carcinoma 193
obesity 153
hypoglycemia 94
glucose intolerance 78
hyperinsulinemia 65
fatty liver 52
cancer 49
tumor 47
metabolic syndrome 41
CAM 34
FAS 31
cold 28
SDS 28
dyslipidemia 28
idiopathic thrombocytopenic purpura 25
hyperlipidemia 21
mole 19
mole 19
hypertension 17
depression 17
Mycobacterium 14
dehydration 12
sepsis 12
Benson 12
GSH 12
sepsis 12
ischemia 11
type 1 diabetes 11
Adenovirus 11
iron deficiency 10
pheochromocytoma 10
hyperphagia 10
tuberculosis 10
PCC 9
Schistosoma mansoni 9
metabolic disorder 9
worms 8
tapeworm 8
Evans 8
ketosis 8
liver cancer 8
schistosomiasis 7
Brown 7
renal disease 7
lactic acidosis 7
Hymenolepis 7
chlorosis 7
vitamin A deficiency 7
herpes simplex 7
tumor growth 7
lipodystrophy 7
infectious diseases 6
Echinococcus 6
tumorigenesis 6
carcinogenesis 6
liver cancer 6
malnutrition 6
leukemia 6
sudden infant death syndrome 6
liver disease 6
cardiovascular disease 6
West 5
AIN 5
endotoxic shock 5
chronic renal failure 5
malaria 5
pertussis 5
wasting syndrome 5
Chagas 5
alcoholic fatty liver 5
atherosclerosis 5
virus infection 5
neuroblastoma 5
gestational diabetes mellitus 4
renal tubular acidosis 4
stroke 4
cytomegalovirus 4
more...
Symptom
starvation 122
acidity 31
exhaustion 10
cachexia 7
fatigue 6
acute stress 6
hepatomegaly 6
anorexia 4
anesthesia 4
polyuria 3
splenomegaly 3
polydipsia 2
overweight 2
pain 2
thinning 2
Decreased activity 1
stigma 1
cough 1
discomfort 1
blackout 1
sleepiness 1
discomfort 1
loss of equilibrium 1
Anoxia 1
hypothermia 1
Tissue anoxia 1
tense 1
dizziness 1
emaciation 1
diarrhea 1
hunger 1
vomiting 1
hyperoxia 1
inanition 1
tremor 1
Drug
NADH 102
lysine 62
Glucagon 42
citric acid 39
CAM 33
Leaf 27
Gel 21
Fructose 19
ROS 17
DNase I 16
Glycerol 12
Asn 11
lactose 11
ascorbate 10
Rosiglitazone 10
Ethanol 9
MAP 9
NH3 8
Growth hormone 7
Alanine 7
Growth hormone 7
Diurnal 5
Aloe 5
Vitamin A 5
Forskolin 4
Troglitazone 4
Kenyan 4
caffeine 4
DMI 4
PCB 3
TAT 3
CoCl2 3
CoCl2 3
CDP 3
Capsicum 3
Scopolamine 3
Bifidobacterium 3
Albumin 2
Arsenic trioxide 2
Mutagen 2
Glycyrrhiza 2
ABC 2
G418 2
Myricetin 2
DEX 2
PTH 2
Retinoic acid 2
Fraction 2
Liraglutide 2
Posilac 2
Monit 2
Monensin 2
Vanilla 2
Portal 2
1-Deoxynojirimycin 2
THF 2
Vitamin B 2
RFP 1
Acyclovir 1
Citrus unshiu peel 1
Phenylphosphate 1
Ranitidine 1
Emodin 1
Riboflavin 1
Aspartic Acid 1
Aminoguanidine 1
Pentostam 1
Ginseng 1
Itraconazole 1
Colombo 1
Glutathione 1
Trilostane 1
CER 1
Salicylate 1
Rasburicase 1
Indomethacin 1
PFA 1
IL-2 1
Asthma 1
TEL 1
more...
Enzyme
phosphoenolpyruvate carboxykinase 4654
phosphoenolpyruvate carboxykinase 4186
phosphoenolpyruvate carboxykinase 4143
phosphoenolpyruvate carboxylase 1393
glucose-6-phosphatase 507
pyruvate kinase 361
pyruvate carboxylase 296
malate dehydrogenase 242
glucokinase 210
protein kinase 192
lactate dehydrogenase 112
AMP-activated protein kinase 109
phosphofructokinase 107
rubisco 98
aspartate aminotransferase 98
fructose 1,6-bisphosphatase 96
glucose-6-phosphate dehydrogenase 89
hexokinase 87
isocitrate dehydrogenase 83
alanine aminotransferase 83
glutamate dehydrogenase 80
glutamate dehydrogenase 80
glutamate dehydrogenase 80
glutamine synthetase 77
citrate synthase 76
pyruvate dehydrogenase 72
AMPK 69
phosphorylase 63
catalase 59
isocitrate dehydrogenase 58
isocitrate lyase 56
AMPK 56
PPDK 55
pyruvate dehydrogenase 54
pyruvate dehydrogenase 54
tyrosine aminotransferase 53
superoxide dismutase 52
acetyl-CoA carboxylase 52
mitogen-activated protein kinase 51
carbonic anhydrase 50
ATPase 47
glyceraldehyde-3-phosphate dehydrogenase 45
fumarase 42
glyceraldehyde-3-phosphate dehydrogenase 42
luciferase 40
CPT 40
succinate dehydrogenase 38
glutaminase 38
lipoprotein lipase 38
chloramphenicol acetyltransferase 37
glyceraldehyde-3-phosphate dehydrogenase 36
glyceraldehyde-3-phosphate dehydrogenase 35
glyceraldehyde-3-phosphate dehydrogenase 33
nitrate reductase 33
nitrate reductase 32
nitrate reductase 32
nitrate reductase 32
nitrate reductase 32
nitrate reductase 32
protein kinase C 31
oxaloacetate decarboxylase 30
glycerol kinase 28
phosphoglycerate kinase 28
phosphatidylinositol 3-kinase 27
aldolase 27
alcohol dehydrogenase 26
succinic dehydrogenase 25
glutamate synthase 25
aconitase 24
glutamate synthase 24
fumarate reductase 23
enolase 23
glutamate synthase 23
acetate kinase 22
calcineurin 22
focal adhesion kinase 22
malate synthase 22
alpha-ketoglutarate dehydrogenase 22
alkaline phosphatase 21
RNA polymerase 21
more...
Compound
glucose 1781
phosphate 386
Dec 344
CO2 300
ATP 274
DNA 269
cAMP 242
water 213
glycerol 186
oxygen 180
alanine 173
nitrogen 164
glutamate 162
AMP 153
PEP 148
acetate 146
Insulin 142
NADP 137
NAD 132
glutamine 131
NAD 110
ADP 110
serine 108
ADP 103
ADP 103
NADH 102
GTP 99
sodium 91
manganese 87
ammonium 85
ammonia 80
pentose 80
pentose 80
pentose 80
pentose 80
lysine 79
calcium 77
urea 76
acetyl-CoA 75
2-oxoglutarate 74
NADPH 73
NADPH 73
oxalacetate 73
ethanol 72
salt 70
Clin 70
glucose-6-phosphate 69
CoA 62
malic acid 61
TCA 59
Mg2+ 56
nitrate 55
arginine 54
sulfate 48
tyrosine 47
Asp 46
hydrogen 45
proline 44
cysteine 44
GDP 44
HCO 43
nicotinamide 43
Glucagon 42
threonine 42
STZ 42
succinic acid 40
TNF 39
carbonate 38
galactose 38
tryptophan 36
hexose 35
hexose 34
tryptophan 34
retinoic acid 34
hexose 34
tryptophan 34
hexose 34
tryptophan 34
CAM 34
leucine 33
more...