Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:4.1.1.49 (
phosphoenolpyruvate carboxykinase
)
4,654
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
.
Concepts found in the documents ranked by [
Frequency
|
Pointwise Mutual Information
|
Symmetric Conditional Probability
] .
Human Gene/Protein
phosphoenolpyruvate carboxykinase
2817
phosphoenolpyruvate carboxylase
1344
insulin
1043
PEPCK
570
glucose-6-phosphatase
505
pyruvate kinase
357
Mol
352
Sep
329
pyruvate carboxylase
279
ATP
274
glucagon
259
CO2
246
malate dehydrogenase
221
glucokinase
207
phosphatase
147
AMP
145
G6Pase
130
NADP
121
PEP
110
NAD
110
lactate dehydrogenase
108
NADH
103
ADP
103
fructose-1,6-bisphosphatase
103
GTP
98
glucocorticoid receptor
93
NADP-malic enzyme
91
phosphofructokinase
91
peroxisome proliferator-activated receptor
89
fatty acid synthase
89
glucose transporter
88
hexokinase
87
aspartate aminotransferase
86
PCK1
86
Bot
86
insulin receptor
81
leptin
80
glutamate dehydrogenase
80
IRS-1
77
glutamine synthetase
77
NADPH
73
citrate synthase
73
glycogen synthase
67
glucose-6-phosphate dehydrogenase
66
rhabdomyosarcoma
63
growth hormone
62
AMP-activated protein kinase
62
PEPCK-C
60
isocitrate dehydrogenase
58
alanine aminotransferase
57
polypeptide
56
AMPK
56
PGC
55
pyruvate dehydrogenase
55
NMR
54
TCA
54
TAT
52
albumin
52
protein kinase B
51
AKT
50
acetyl-CoA carboxylase
50
peroxisome proliferator-activated receptor gamma
49
catalase
49
carbonic anhydrase
49
glycogen phosphorylase
49
NAD-malic enzyme
47
fructose 1,6-bisphosphatase
46
proximal tubule
46
superoxide dismutase
43
GDP
43
EBP
40
ATPase
40
CREB
40
TNF
39
fused
39
epididymal
38
lipoprotein lipase
38
glutaminase
34
nuclear receptor
34
fumarase
34
glyceraldehyde-3-phosphate dehydrogenase
33
Pyruvate carboxylase
33
CAM
33
PI3K
33
adiponectin
32
cytokine
32
hemoglobin
32
threonine
31
FAS
31
GLUT4
31
carboxylating
31
GLUT2
31
tumor necrosis factor
30
NADP-ME
30
reductase
30
STZ
29
PCK2
29
decarboxylating
29
SDS
28
Gen
28
metallothionein
28
HDL
27
insulin-like growth factor
26
phosphatidylinositol 3-kinase
26
endoplasmic reticulum
25
casein
24
alcohol dehydrogenase
24
histone
24
glycolytic enzyme
24
NAD-ME
24
Pseudomonas
24
enolase
23
IL-6
23
NAD+
23
carnitine palmitoyltransferase
23
IDP
22
PEPCK-M
22
cAMP-response element
22
glucose transporter 4
22
thyroid hormone
22
IGF-I
21
collagen
21
ubiquitin
21
aconitase
21
phosphate-activated glutaminase
21
sterol regulatory element-binding protein
20
GLUT1
20
6-phosphogluconate dehydrogenase
20
alkaline phosphatase
20
mTOR
20
PPAR
19
SHP
19
transferrin
19
SREBP-1c
19
phosphoglycerate kinase
19
phosphoinositide 3-kinase
19
HSD1
19
GSK
19
nuclear protein
19
lipopolysaccharide
19
hormone-sensitive lipase
19
phosphodiesterase
18
calmodulin
18
ACC
18
p38
17
glycerol kinase
17
CPT
17
protein phosphatase
17
IRS-2
17
C/EBP alpha
17
ROS
17
forkhead transcription factor
17
MAPK
17
thymidine kinase
17
insulin receptor substrate
17
housekeeping
16
ACL
16
SREBP-1
16
LL)
16
glycine decarboxylase
16
more...
Disease
diabetes
350
type 2 diabetes
216
hyperglycemia
216
hepatocellular carcinoma
193
obesity
153
hypoglycemia
94
glucose intolerance
78
hyperinsulinemia
65
fatty liver
52
cancer
49
tumor
47
metabolic syndrome
41
CAM
34
FAS
31
cold
28
dyslipidemia
28
SDS
28
idiopathic thrombocytopenic purpura
25
hyperlipidemia
21
mole
19
mole
19
hypertension
17
depression
17
Mycobacterium
14
dehydration
12
GSH
12
Benson
12
sepsis
12
sepsis
12
type 1 diabetes
11
ischemia
11
Adenovirus
11
tuberculosis
10
iron deficiency
10
hyperphagia
10
pheochromocytoma
10
PCC
9
Schistosoma mansoni
9
metabolic disorder
9
Evans
8
ketosis
8
worms
8
tapeworm
8
liver cancer
8
lactic acidosis
7
renal disease
7
schistosomiasis
7
Hymenolepis
7
Brown
7
lipodystrophy
7
tumor growth
7
vitamin A deficiency
7
herpes simplex
7
chlorosis
7
Echinococcus
6
infectious diseases
6
liver cancer
6
tumorigenesis
6
leukemia
6
sudden infant death syndrome
6
liver disease
6
cardiovascular disease
6
carcinogenesis
6
malnutrition
6
malaria
5
endotoxic shock
5
neuroblastoma
5
AIN
5
chronic renal failure
5
West
5
alcoholic fatty liver
5
Chagas
5
pertussis
5
atherosclerosis
5
virus infection
5
wasting syndrome
5
NAME
4
stroke
4
Pituitary
4
cytomegalovirus
4
Nonalcoholic fatty liver
4
renal tubular acidosis
4
coronary artery disease
4
HIV
4
seminal vesicles
4
gestational diabetes mellitus
4
fits
4
hepatitis B
4
hepatitis C
4
insulinoma
4
renal ischemia
4
overnutrition
4
Infection
4
hyperthyroidism
4
Mohr
4
breast cancer
4
PER
4
PDB
4
diabetic nephropathy
4
hypothyroidism
4
polycystic ovary syndrome
4
Syndrome
3
colon cancer
3
endocrine disorder
3
suicide
3
bacterial infection
3
metabolic alkalosis
3
wasting
3
carcinoma
3
PGA
3
gestational trophoblastic disease
3
lung cancer
3
leishmaniasis
3
chronic hepatitis
3
hepatitis
3
cirrhosis
3
fascioliasis
3
cerebral ischemia
3
thiamine deficiency
3
Alzheimer's disease
3
Blocking
3
Mycoplasma
3
cholestasis
3
infertility
3
multiple myeloma
3
adrenal insufficiency
3
peritonitis
3
MODY
3
melanoma
3
Pancreas
2
SAR
2
hepatic porphyria
2
Brucella abortus
2
Cryptococcus neoformans
2
KMS
2
uterus
2
Robinson
2
mammary tumor
2
parasitic disease
2
non-small cell lung cancer
2
embryonal carcinoma
2
retinopathy of prematurity
2
SCD
2
sarcoma
2
respiratory disease
2
Parkinson's disease
2
renal failure
2
coenurosis
2
SEM
2
Leigh syndrome
2
Klebsiella
2
arthritis
2
rheumatoid arthritis
2
porphyria cutanea tarda
2
tumor progression
2
infestation
2
Pineal
2
Recruitment
2
ash
2
leprosy
2
more...
Symptom
starvation
122
acidity
31
exhaustion
10
cachexia
7
fatigue
6
acute stress
6
hepatomegaly
6
anorexia
4
anesthesia
4
polyuria
3
splenomegaly
3
polydipsia
2
overweight
2
pain
2
thinning
2
Decreased activity
1
stigma
1
cough
1
discomfort
1
blackout
1
sleepiness
1
discomfort
1
loss of equilibrium
1
Anoxia
1
hypothermia
1
Tissue anoxia
1
tense
1
dizziness
1
emaciation
1
diarrhea
1
hunger
1
vomiting
1
hyperoxia
1
inanition
1
tremor
1
Drug
NADH
102
lysine
62
Glucagon
42
citric acid
39
CAM
33
Leaf
27
Gel
21
Fructose
19
ROS
17
DNase I
16
Glycerol
12
Asn
11
lactose
11
Rosiglitazone
10
ascorbate
10
Ethanol
9
MAP
9
NH3
8
Alanine
7
Growth hormone
7
Growth hormone
7
Aloe
5
Vitamin A
5
Diurnal
5
caffeine
4
Troglitazone
4
Kenyan
4
DMI
4
Forskolin
4
CoCl2
3
TAT
3
CDP
3
Capsicum
3
Scopolamine
3
CoCl2
3
Bifidobacterium
3
PCB
3
Arsenic trioxide
2
G418
2
Albumin
2
Glycyrrhiza
2
ABC
2
1-Deoxynojirimycin
2
Myricetin
2
DEX
2
Monit
2
Monensin
2
Portal
2
Liraglutide
2
Posilac
2
PTH
2
Vanilla
2
THF
2
Fraction
2
Mutagen
2
Retinoic acid
2
Vitamin B
2
RFP
1
Pyridoxamine
1
Nipradilol
1
Emodin
1
Heme
1
Acyclovir
1
TAK
1
Citrus unshiu peel
1
MRC
1
Phenylphosphate
1
Ranitidine
1
Itraconazole
1
Colombo
1
Emodin
1
Riboflavin
1
Aspartic Acid
1
Aminoguanidine
1
Pentostam
1
Ginseng
1
Trilostane
1
Glutathione
1
niacin
1
Salicylate
1
EPA
1
Honey
1
Adenosine triphosphate
1
CER
1
pyridoxal phosphate
1
OTC
1
Rasburicase
1
Indomethacin
1
PFA
1
Carbenoxolone
1
TEL
1
Ammonium chloride
1
Asthma
1
balanced salt solution
1
ampicillin
1
IL-2
1
Calan
1
Nephron
1
OTC
1
Gemfibrozil
1
Sodium sulfate
1
Dasatinib
1
Dermatol
1
Triclosan
1
Flavin
1
AGG
1
Glutamic acid
1
Asparaginase
1
Carotenoid
1
Orphan
1
CDX
1
IL-11
1
CDX
1
CaCl2
1
CaCl2
1
Cottonseed oil
1
p-Chlorophenyl
1
Vitamin B12
1
Atropine
1
Clofibrate
1
Isoptin
1
Enrofloxacin
1
PTC
1
ALA
1
Prednisolone
1
Exenatide
1
TAC
1
FAD
1
Sulfopyruvate
1
Valsartan
1
Nephron
1
Ipriflavone
1
vitamin E
1
EE2
1
Citric acid
1
beta-Galactosidase
1
CaCl2
1
Indocyanine green
1
Coral
1
Enzyme
phosphoenolpyruvate carboxykinase
4654
phosphoenolpyruvate carboxykinase
4186
phosphoenolpyruvate carboxykinase
4143
phosphoenolpyruvate carboxylase
1393
glucose-6-phosphatase
507
pyruvate kinase
361
pyruvate carboxylase
296
malate dehydrogenase
242
glucokinase
210
protein kinase
192
lactate dehydrogenase
112
AMP-activated protein kinase
109
phosphofructokinase
107
rubisco
98
aspartate aminotransferase
98
fructose 1,6-bisphosphatase
96
glucose-6-phosphate dehydrogenase
89
hexokinase
87
alanine aminotransferase
83
isocitrate dehydrogenase
83
glutamate dehydrogenase
80
glutamate dehydrogenase
80
glutamate dehydrogenase
80
glutamine synthetase
77
citrate synthase
76
pyruvate dehydrogenase
72
AMPK
69
phosphorylase
63
catalase
59
isocitrate dehydrogenase
58
AMPK
56
isocitrate lyase
56
PPDK
55
pyruvate dehydrogenase
54
pyruvate dehydrogenase
54
tyrosine aminotransferase
53
superoxide dismutase
52
acetyl-CoA carboxylase
52
mitogen-activated protein kinase
51
carbonic anhydrase
50
ATPase
47
glyceraldehyde-3-phosphate dehydrogenase
45
glyceraldehyde-3-phosphate dehydrogenase
42
fumarase
42
luciferase
40
CPT
40
glutaminase
38
succinate dehydrogenase
38
lipoprotein lipase
38
chloramphenicol acetyltransferase
37
glyceraldehyde-3-phosphate dehydrogenase
36
glyceraldehyde-3-phosphate dehydrogenase
35
glyceraldehyde-3-phosphate dehydrogenase
33
nitrate reductase
33
nitrate reductase
32
nitrate reductase
32
nitrate reductase
32
nitrate reductase
32
nitrate reductase
32
protein kinase C
31
oxaloacetate decarboxylase
30
glycerol kinase
28
phosphoglycerate kinase
28
phosphatidylinositol 3-kinase
27
aldolase
27
alcohol dehydrogenase
26
glutamate synthase
25
succinic dehydrogenase
25
aconitase
24
glutamate synthase
24
glutamate synthase
23
enolase
23
fumarate reductase
23
alpha-ketoglutarate dehydrogenase
22
calcineurin
22
focal adhesion kinase
22
malate synthase
22
acetate kinase
22
alkaline phosphatase
21
RNA polymerase
21
6-phosphogluconate dehydrogenase
20
6-phosphogluconate dehydrogenase
20
GSK
19
adenylate cyclase
19
phosphoinositide 3-kinase
19
ornithine transcarbamylase
19
hormone-sensitive lipase
19
phosphodiesterase
18
glycine decarboxylase
18
thymidine kinase
17
11beta-hydroxysteroid dehydrogenase
17
CPT
17
CPT
17
PDK1
16
argininosuccinate synthetase
16
ERK
16
glycerol-3-phosphate dehydrogenase
15
glycerol-3-phosphate dehydrogenase
15
ACS
15
peroxidase
15
trypsin
15
glutathione peroxidase
15
carbamoylphosphate synthetase
15
sucrose synthase
15
EC 1.1.1.40
14
complex I
14
lipase
14
phosphoglucose isomerase
14
adenylate kinase
14
proteasome
14
acetyl-CoA synthetase
13
MDH
12
phosphoenolpyruvate synthase
12
collagenase
12
MDH
12
invertase
12
beta-glucuronidase
12
PTA
11
reverse transcriptase
11
glutathione reductase
11
acyl-CoA oxidase
11
ascorbate peroxidase
11
CPS
11
6-phosphofructo-2-kinase
11
LPL
11
arginase
11
tryptophan 2,3-dioxygenase
11
citrate lyase
10
NADPH oxidase
10
propionyl-CoA carboxylase
10
AST
10
aspartokinase
10
transhydrogenase
10
pyruvate:ferredoxin oxidoreductase
9
diaphorase
9
hydrogenase
9
ornithine decarboxylase
9
NADPH oxidase
9
hydrogenase
9
asparagine synthetase
9
nitrogenase
9
PEP phosphatase
9
ATP synthase
9
AMP-activated kinase
9
diacylglycerol acyltransferase
9
propionyl-CoA carboxylase
8
HMG-CoA synthase
8
ADP-glucose pyrophosphorylase
8
NO synthase
8
CYP7A1
8
glutathione S-transferase
8
formate dehydrogenase
7
hydroxypyruvate reductase
7
NADH dehydrogenase
7
acyl-CoA dehydrogenase
7
hydroxypyruvate reductase
7
gamma-glutamyl transpeptidase
7
SCS
7
formate dehydrogenase
7
pyruvate decarboxylase
7
more...
Compound
glucose
1781
phosphate
386
Dec
344
CO2
300
ATP
274
DNA
269
cAMP
242
water
213
glycerol
186
oxygen
180
alanine
173
nitrogen
164
glutamate
162
AMP
153
PEP
148
acetate
146
Insulin
142
NADP
137
NAD
132
glutamine
131
NAD
110
ADP
110
serine
108
ADP
103
ADP
103
NADH
102
GTP
99
sodium
91
manganese
87
ammonium
85
pentose
80
ammonia
80
pentose
80
pentose
80
pentose
80
lysine
79
calcium
77
urea
76
acetyl-CoA
75
2-oxoglutarate
74
oxalacetate
73
NADPH
73
NADPH
73
ethanol
72
salt
70
Clin
70
glucose-6-phosphate
69
CoA
62
malic acid
61
TCA
59
Mg2+
56
nitrate
55
arginine
54
sulfate
48
tyrosine
47
Asp
46
hydrogen
45
proline
44
GDP
44
cysteine
44
nicotinamide
43
HCO
43
STZ
42
threonine
42
Glucagon
42
succinic acid
40
TNF
39
carbonate
38
galactose
38
tryptophan
36
hexose
35
CAM
34
tryptophan
34
hexose
34
tryptophan
34
tryptophan
34
hexose
34
retinoic acid
34
hexose
34
leucine
33
malic acid
33
Pyruvate
33
malic acid
32
malic acid
32
Malate
31
Lactate
31
Dexamethasone
31
nitric oxide
30
NH2
30
methionine
30
iron
30
His
30
asparagine
28
Gly
28
Phe
28
SDS
28
ITP
27
alloxan
27
cadmium
27
potassium
27
aspartic acid
27
Sucrose
27
aspartic acid
25
alcohol dehydrogenase
25
succinic acid
24
succinic acid
24
succinic acid
24
succinic acid
24
acetic acid
23
glutamic acid
23
IDP
22
aspartic acid
22
phosphorus
22
aspartic acid
22
PEG
20
isocitrate
20
Glycogen
19
Fructose
19
zinc
18
CPT
17
CPT
17
Carbon
17
H2O2
17
cobalt
17
methanol
17
valine
17
dicarboxylic acid
17
Ile
16
Phytol
15
adenylate
15
PEG
15
Glutamate
15
Phytol
15
Glutamine
14
ATF
14
isoleucine
14
palmitic acid
14
copper
13
Chlorophyll
13
GSH
13
Glucose 6-phosphate
13
isoleucine
13
CIT
13
GSH
13
oxalate
13
PPi
12
CAT
12
CAT
12
CAT
12
malonyl-CoA
12
Flux
12
ACTH
11
NO3
11
GAP
11
Pyruvate kinase
11
xylose
11
Ribulose
11
cyanide
11
silver
10
AICAR
10
more...