Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:4.1.1.49 (phosphoenolpyruvate carboxykinase)
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Human Gene/Protein
phosphoenolpyruvate carboxykinase 2817
phosphoenolpyruvate carboxylase 1344
insulin 1043
PEPCK 570
glucose-6-phosphatase 505
pyruvate kinase 357
Mol 352
Sep 329
pyruvate carboxylase 279
ATP 274
glucagon 259
CO2 246
malate dehydrogenase 221
glucokinase 207
phosphatase 147
AMP 145
G6Pase 130
NADP 121
PEP 110
NAD 110
lactate dehydrogenase 108
NADH 103
ADP 103
fructose-1,6-bisphosphatase 103
GTP 98
glucocorticoid receptor 93
NADP-malic enzyme 91
phosphofructokinase 91
peroxisome proliferator-activated receptor 89
fatty acid synthase 89
glucose transporter 88
hexokinase 87
aspartate aminotransferase 86
PCK1 86
Bot 86
insulin receptor 81
leptin 80
glutamate dehydrogenase 80
IRS-1 77
glutamine synthetase 77
NADPH 73
citrate synthase 73
glycogen synthase 67
glucose-6-phosphate dehydrogenase 66
rhabdomyosarcoma 63
growth hormone 62
AMP-activated protein kinase 62
PEPCK-C 60
isocitrate dehydrogenase 58
alanine aminotransferase 57
polypeptide 56
AMPK 56
PGC 55
pyruvate dehydrogenase 55
NMR 54
TCA 54
TAT 52
albumin 52
protein kinase B 51
AKT 50
acetyl-CoA carboxylase 50
peroxisome proliferator-activated receptor gamma 49
catalase 49
carbonic anhydrase 49
glycogen phosphorylase 49
NAD-malic enzyme 47
fructose 1,6-bisphosphatase 46
proximal tubule 46
superoxide dismutase 43
GDP 43
EBP 40
ATPase 40
CREB 40
TNF 39
fused 39
epididymal 38
lipoprotein lipase 38
glutaminase 34
nuclear receptor 34
fumarase 34
glyceraldehyde-3-phosphate dehydrogenase 33
Pyruvate carboxylase 33
CAM 33
PI3K 33
adiponectin 32
cytokine 32
hemoglobin 32
threonine 31
FAS 31
GLUT4 31
carboxylating 31
GLUT2 31
tumor necrosis factor 30
NADP-ME 30
reductase 30
STZ 29
PCK2 29
decarboxylating 29
SDS 28
Gen 28
metallothionein 28
HDL 27
insulin-like growth factor 26
phosphatidylinositol 3-kinase 26
endoplasmic reticulum 25
casein 24
alcohol dehydrogenase 24
histone 24
glycolytic enzyme 24
NAD-ME 24
Pseudomonas 24
enolase 23
IL-6 23
NAD+ 23
carnitine palmitoyltransferase 23
IDP 22
PEPCK-M 22
cAMP-response element 22
glucose transporter 4 22
thyroid hormone 22
IGF-I 21
collagen 21
ubiquitin 21
aconitase 21
phosphate-activated glutaminase 21
sterol regulatory element-binding protein 20
GLUT1 20
6-phosphogluconate dehydrogenase 20
alkaline phosphatase 20
mTOR 20
PPAR 19
SHP 19
transferrin 19
SREBP-1c 19
phosphoglycerate kinase 19
phosphoinositide 3-kinase 19
HSD1 19
GSK 19
nuclear protein 19
lipopolysaccharide 19
hormone-sensitive lipase 19
phosphodiesterase 18
calmodulin 18
ACC 18
p38 17
glycerol kinase 17
CPT 17
protein phosphatase 17
IRS-2 17
C/EBP alpha 17
ROS 17
forkhead transcription factor 17
MAPK 17
thymidine kinase 17
insulin receptor substrate 17
housekeeping 16
ACL 16
SREBP-1 16
LL) 16
glycine decarboxylase 16
more...
Disease
diabetes 350
type 2 diabetes 216
hyperglycemia 216
hepatocellular carcinoma 193
obesity 153
hypoglycemia 94
glucose intolerance 78
hyperinsulinemia 65
fatty liver 52
cancer 49
tumor 47
metabolic syndrome 41
CAM 34
FAS 31
cold 28
dyslipidemia 28
SDS 28
idiopathic thrombocytopenic purpura 25
hyperlipidemia 21
mole 19
mole 19
hypertension 17
depression 17
Mycobacterium 14
dehydration 12
GSH 12
Benson 12
sepsis 12
sepsis 12
type 1 diabetes 11
ischemia 11
Adenovirus 11
tuberculosis 10
iron deficiency 10
hyperphagia 10
pheochromocytoma 10
PCC 9
Schistosoma mansoni 9
metabolic disorder 9
Evans 8
ketosis 8
worms 8
tapeworm 8
liver cancer 8
lactic acidosis 7
renal disease 7
schistosomiasis 7
Hymenolepis 7
Brown 7
lipodystrophy 7
tumor growth 7
vitamin A deficiency 7
herpes simplex 7
chlorosis 7
Echinococcus 6
infectious diseases 6
liver cancer 6
tumorigenesis 6
leukemia 6
sudden infant death syndrome 6
liver disease 6
cardiovascular disease 6
carcinogenesis 6
malnutrition 6
malaria 5
endotoxic shock 5
neuroblastoma 5
AIN 5
chronic renal failure 5
West 5
alcoholic fatty liver 5
Chagas 5
pertussis 5
atherosclerosis 5
virus infection 5
wasting syndrome 5
NAME 4
stroke 4
Pituitary 4
cytomegalovirus 4
Nonalcoholic fatty liver 4
renal tubular acidosis 4
coronary artery disease 4
HIV 4
seminal vesicles 4
gestational diabetes mellitus 4
fits 4
hepatitis B 4
hepatitis C 4
insulinoma 4
renal ischemia 4
overnutrition 4
Infection 4
hyperthyroidism 4
Mohr 4
breast cancer 4
PER 4
PDB 4
diabetic nephropathy 4
hypothyroidism 4
polycystic ovary syndrome 4
Syndrome 3
colon cancer 3
endocrine disorder 3
suicide 3
bacterial infection 3
metabolic alkalosis 3
wasting 3
carcinoma 3
PGA 3
gestational trophoblastic disease 3
lung cancer 3
leishmaniasis 3
chronic hepatitis 3
hepatitis 3
cirrhosis 3
fascioliasis 3
cerebral ischemia 3
thiamine deficiency 3
Alzheimer's disease 3
Blocking 3
Mycoplasma 3
cholestasis 3
infertility 3
multiple myeloma 3
adrenal insufficiency 3
peritonitis 3
MODY 3
melanoma 3
Pancreas 2
SAR 2
hepatic porphyria 2
Brucella abortus 2
Cryptococcus neoformans 2
KMS 2
uterus 2
Robinson 2
mammary tumor 2
parasitic disease 2
non-small cell lung cancer 2
embryonal carcinoma 2
retinopathy of prematurity 2
SCD 2
sarcoma 2
respiratory disease 2
Parkinson's disease 2
renal failure 2
coenurosis 2
SEM 2
Leigh syndrome 2
Klebsiella 2
arthritis 2
rheumatoid arthritis 2
porphyria cutanea tarda 2
tumor progression 2
infestation 2
Pineal 2
Recruitment 2
ash 2
leprosy 2
more...
Symptom
starvation 122
acidity 31
exhaustion 10
cachexia 7
fatigue 6
acute stress 6
hepatomegaly 6
anorexia 4
anesthesia 4
polyuria 3
splenomegaly 3
polydipsia 2
overweight 2
pain 2
thinning 2
Decreased activity 1
stigma 1
cough 1
discomfort 1
blackout 1
sleepiness 1
discomfort 1
loss of equilibrium 1
Anoxia 1
hypothermia 1
Tissue anoxia 1
tense 1
dizziness 1
emaciation 1
diarrhea 1
hunger 1
vomiting 1
hyperoxia 1
inanition 1
tremor 1
Drug
NADH 102
lysine 62
Glucagon 42
citric acid 39
CAM 33
Leaf 27
Gel 21
Fructose 19
ROS 17
DNase I 16
Glycerol 12
Asn 11
lactose 11
Rosiglitazone 10
ascorbate 10
Ethanol 9
MAP 9
NH3 8
Alanine 7
Growth hormone 7
Growth hormone 7
Aloe 5
Vitamin A 5
Diurnal 5
caffeine 4
Troglitazone 4
Kenyan 4
DMI 4
Forskolin 4
CoCl2 3
TAT 3
CDP 3
Capsicum 3
Scopolamine 3
CoCl2 3
Bifidobacterium 3
PCB 3
Arsenic trioxide 2
G418 2
Albumin 2
Glycyrrhiza 2
ABC 2
1-Deoxynojirimycin 2
Myricetin 2
DEX 2
Monit 2
Monensin 2
Portal 2
Liraglutide 2
Posilac 2
PTH 2
Vanilla 2
THF 2
Fraction 2
Mutagen 2
Retinoic acid 2
Vitamin B 2
RFP 1
Pyridoxamine 1
Nipradilol 1
Emodin 1
Heme 1
Acyclovir 1
TAK 1
Citrus unshiu peel 1
MRC 1
Phenylphosphate 1
Ranitidine 1
Itraconazole 1
Colombo 1
Emodin 1
Riboflavin 1
Aspartic Acid 1
Aminoguanidine 1
Pentostam 1
Ginseng 1
Trilostane 1
Glutathione 1
niacin 1
Salicylate 1
EPA 1
Honey 1
Adenosine triphosphate 1
CER 1
pyridoxal phosphate 1
OTC 1
Rasburicase 1
Indomethacin 1
PFA 1
Carbenoxolone 1
TEL 1
Ammonium chloride 1
Asthma 1
balanced salt solution 1
ampicillin 1
IL-2 1
Calan 1
Nephron 1
OTC 1
Gemfibrozil 1
Sodium sulfate 1
Dasatinib 1
Dermatol 1
Triclosan 1
Flavin 1
AGG 1
Glutamic acid 1
Asparaginase 1
Carotenoid 1
Orphan 1
CDX 1
IL-11 1
CDX 1
CaCl2 1
CaCl2 1
Cottonseed oil 1
p-Chlorophenyl 1
Vitamin B12 1
Atropine 1
Clofibrate 1
Isoptin 1
Enrofloxacin 1
PTC 1
ALA 1
Prednisolone 1
Exenatide 1
TAC 1
FAD 1
Sulfopyruvate 1
Valsartan 1
Nephron 1
Ipriflavone 1
vitamin E 1
EE2 1
Citric acid 1
beta-Galactosidase 1
CaCl2 1
Indocyanine green 1
Coral 1
Enzyme
phosphoenolpyruvate carboxykinase 4654
phosphoenolpyruvate carboxykinase 4186
phosphoenolpyruvate carboxykinase 4143
phosphoenolpyruvate carboxylase 1393
glucose-6-phosphatase 507
pyruvate kinase 361
pyruvate carboxylase 296
malate dehydrogenase 242
glucokinase 210
protein kinase 192
lactate dehydrogenase 112
AMP-activated protein kinase 109
phosphofructokinase 107
rubisco 98
aspartate aminotransferase 98
fructose 1,6-bisphosphatase 96
glucose-6-phosphate dehydrogenase 89
hexokinase 87
alanine aminotransferase 83
isocitrate dehydrogenase 83
glutamate dehydrogenase 80
glutamate dehydrogenase 80
glutamate dehydrogenase 80
glutamine synthetase 77
citrate synthase 76
pyruvate dehydrogenase 72
AMPK 69
phosphorylase 63
catalase 59
isocitrate dehydrogenase 58
AMPK 56
isocitrate lyase 56
PPDK 55
pyruvate dehydrogenase 54
pyruvate dehydrogenase 54
tyrosine aminotransferase 53
superoxide dismutase 52
acetyl-CoA carboxylase 52
mitogen-activated protein kinase 51
carbonic anhydrase 50
ATPase 47
glyceraldehyde-3-phosphate dehydrogenase 45
glyceraldehyde-3-phosphate dehydrogenase 42
fumarase 42
luciferase 40
CPT 40
glutaminase 38
succinate dehydrogenase 38
lipoprotein lipase 38
chloramphenicol acetyltransferase 37
glyceraldehyde-3-phosphate dehydrogenase 36
glyceraldehyde-3-phosphate dehydrogenase 35
glyceraldehyde-3-phosphate dehydrogenase 33
nitrate reductase 33
nitrate reductase 32
nitrate reductase 32
nitrate reductase 32
nitrate reductase 32
nitrate reductase 32
protein kinase C 31
oxaloacetate decarboxylase 30
glycerol kinase 28
phosphoglycerate kinase 28
phosphatidylinositol 3-kinase 27
aldolase 27
alcohol dehydrogenase 26
glutamate synthase 25
succinic dehydrogenase 25
aconitase 24
glutamate synthase 24
glutamate synthase 23
enolase 23
fumarate reductase 23
alpha-ketoglutarate dehydrogenase 22
calcineurin 22
focal adhesion kinase 22
malate synthase 22
acetate kinase 22
alkaline phosphatase 21
RNA polymerase 21
6-phosphogluconate dehydrogenase 20
6-phosphogluconate dehydrogenase 20
GSK 19
adenylate cyclase 19
phosphoinositide 3-kinase 19
ornithine transcarbamylase 19
hormone-sensitive lipase 19
phosphodiesterase 18
glycine decarboxylase 18
thymidine kinase 17
11beta-hydroxysteroid dehydrogenase 17
CPT 17
CPT 17
PDK1 16
argininosuccinate synthetase 16
ERK 16
glycerol-3-phosphate dehydrogenase 15
glycerol-3-phosphate dehydrogenase 15
ACS 15
peroxidase 15
trypsin 15
glutathione peroxidase 15
carbamoylphosphate synthetase 15
sucrose synthase 15
EC 1.1.1.40 14
complex I 14
lipase 14
phosphoglucose isomerase 14
adenylate kinase 14
proteasome 14
acetyl-CoA synthetase 13
MDH 12
phosphoenolpyruvate synthase 12
collagenase 12
MDH 12
invertase 12
beta-glucuronidase 12
PTA 11
reverse transcriptase 11
glutathione reductase 11
acyl-CoA oxidase 11
ascorbate peroxidase 11
CPS 11
6-phosphofructo-2-kinase 11
LPL 11
arginase 11
tryptophan 2,3-dioxygenase 11
citrate lyase 10
NADPH oxidase 10
propionyl-CoA carboxylase 10
AST 10
aspartokinase 10
transhydrogenase 10
pyruvate:ferredoxin oxidoreductase 9
diaphorase 9
hydrogenase 9
ornithine decarboxylase 9
NADPH oxidase 9
hydrogenase 9
asparagine synthetase 9
nitrogenase 9
PEP phosphatase 9
ATP synthase 9
AMP-activated kinase 9
diacylglycerol acyltransferase 9
propionyl-CoA carboxylase 8
HMG-CoA synthase 8
ADP-glucose pyrophosphorylase 8
NO synthase 8
CYP7A1 8
glutathione S-transferase 8
formate dehydrogenase 7
hydroxypyruvate reductase 7
NADH dehydrogenase 7
acyl-CoA dehydrogenase 7
hydroxypyruvate reductase 7
gamma-glutamyl transpeptidase 7
SCS 7
formate dehydrogenase 7
pyruvate decarboxylase 7
more...
Compound
glucose 1781
phosphate 386
Dec 344
CO2 300
ATP 274
DNA 269
cAMP 242
water 213
glycerol 186
oxygen 180
alanine 173
nitrogen 164
glutamate 162
AMP 153
PEP 148
acetate 146
Insulin 142
NADP 137
NAD 132
glutamine 131
NAD 110
ADP 110
serine 108
ADP 103
ADP 103
NADH 102
GTP 99
sodium 91
manganese 87
ammonium 85
pentose 80
ammonia 80
pentose 80
pentose 80
pentose 80
lysine 79
calcium 77
urea 76
acetyl-CoA 75
2-oxoglutarate 74
oxalacetate 73
NADPH 73
NADPH 73
ethanol 72
salt 70
Clin 70
glucose-6-phosphate 69
CoA 62
malic acid 61
TCA 59
Mg2+ 56
nitrate 55
arginine 54
sulfate 48
tyrosine 47
Asp 46
hydrogen 45
proline 44
GDP 44
cysteine 44
nicotinamide 43
HCO 43
STZ 42
threonine 42
Glucagon 42
succinic acid 40
TNF 39
carbonate 38
galactose 38
tryptophan 36
hexose 35
CAM 34
tryptophan 34
hexose 34
tryptophan 34
tryptophan 34
hexose 34
retinoic acid 34
hexose 34
leucine 33
malic acid 33
Pyruvate 33
malic acid 32
malic acid 32
Malate 31
Lactate 31
Dexamethasone 31
nitric oxide 30
NH2 30
methionine 30
iron 30
His 30
asparagine 28
Gly 28
Phe 28
SDS 28
ITP 27
alloxan 27
cadmium 27
potassium 27
aspartic acid 27
Sucrose 27
aspartic acid 25
alcohol dehydrogenase 25
succinic acid 24
succinic acid 24
succinic acid 24
succinic acid 24
acetic acid 23
glutamic acid 23
IDP 22
aspartic acid 22
phosphorus 22
aspartic acid 22
PEG 20
isocitrate 20
Glycogen 19
Fructose 19
zinc 18
CPT 17
CPT 17
Carbon 17
H2O2 17
cobalt 17
methanol 17
valine 17
dicarboxylic acid 17
Ile 16
Phytol 15
adenylate 15
PEG 15
Glutamate 15
Phytol 15
Glutamine 14
ATF 14
isoleucine 14
palmitic acid 14
copper 13
Chlorophyll 13
GSH 13
Glucose 6-phosphate 13
isoleucine 13
CIT 13
GSH 13
oxalate 13
PPi 12
CAT 12
CAT 12
CAT 12
malonyl-CoA 12
Flux 12
ACTH 11
NO3 11
GAP 11
Pyruvate kinase 11
xylose 11
Ribulose 11
cyanide 11
silver 10
AICAR 10
more...