Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:4.1.1.32 (phosphoenolpyruvate carboxykinase)
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Human Gene/Protein
Hepatic nuclear factor 4 alpha 12.9
phosphoenolpyruvate carboxykinase 12.8
phosphoenolpyruvate carboxylase 12.7
PEPCK-C 12.3
PEPCK-M 12.2
pyruvate carboxylase, mitochondrial 11.9
zinc finger homeodomain protein 11.9
PCK1 11.6
PCK2 11.6
NADP-malic enzyme 11.6
TCDD-inducible poly(ADP-ribose) polymerase 11.3
NAD-malic enzyme 11.2
NAD-ME 11.1
PEPCK 11.1
MRP-S9 10.9
NADP-ME 10.8
cytochrome c-1 10.6
pyruvate carboxylase 10.5
TSE1 10.3
CPS1 protein 10.3
Glutamic dehydrogenase 10.3
glucose-6-phosphatase 10.2
carboxylating 10.2
fructose-bisphosphatase 10.1
APC2 protein 10.1
dihydrolipoamide S-succinyltransferase 10.1
fructose 1,6-bisphosphatase 10.0
Forkhead/winged helix transcription factor 9.9
phosphoenolpyruvate carboxykinase 2 9.9
AREBP 9.9
PDE3B protein 9.9
Tissue-specific extinguisher 1 9.7
glycerokinase 9.7
Fructose-bisphosphate aldolase 9.7
NADP-dependent malic enzyme 9.7
pyruvate kinase L 9.6
fructose-1,6-bisphosphatase 9.6
Fructose 1,6-bisphosphatase 9.6
G6Pase 9.5
Pyruvate carboxylase 9.5
1-acylglycerol-3-phosphate O-acyltransferase 2 9.4
phosphorylase, glycogen 9.4
ZHX3 9.3
RFWD2 9.3
carbamoylphosphate synthetase I 9.3
ZFP91 9.3
Malic enzyme 9.2
ME5 9.2
S171 9.2
fructose-1,6-bisphosphatase 1 9.1
serine dehydratase 9.1
constitutive heat shock protein 70 9.1
succinate dehydrogenase flavoprotein subunit 9.1
Glucose-6-phosphatase 9.1
liver glycogen synthase 9.1
ESA1 9.0
FEEL-1 9.0
glycine dehydrogenase 9.0
pck2 9.0
CAT5 9.0
glucokinase 9.0
FBP1 8.9
pyruvate kinase 8.9
GSD1a 8.9
6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 8.9
decarboxylating 8.9
IDP 8.8
phosphate-activated glutaminase 8.8
Malate dehydrogenase 8.8
DOC1 8.8
PFK-2/FBPase-2 8.8
APOC4 8.8
malate dehydrogenase 8.8
MDH2 8.8
RGPR-p117 8.7
tubulin beta chain 8.7
D-fructose-1,6-bisphosphate 1-phosphohydrolase 8.7
SLC27A2 8.7
BHLHE40 8.7
ATP-binding cassette transporter-1 8.6
more...
Disease
Glucagon resistance 10.9
Avian reticuloendotheliosis 10.6
ALAD deficiency 9.0
Brain mass 8.7
Fasting hypoglycemia 8.1
Biotin deficiency 7.9
CPS deficiency 7.6
Paxton 7.6
Hers 7.2
porcine stress syndrome 7.0
Benson 6.8
Mohr 6.7
PNP deficiency 6.6
disorders of amino acid metabolism 6.6
MODY1 6.4
PDH deficiency 6.4
coenurosis 6.3
diphyllobothriasis 6.1
diabetic hyperglycemia 6.0
AD1 6.0
orotic aciduria 6.0
hepatic porphyria 6.0
Jejunum 5.8
postmaturity 5.7
lymphoblastoma 5.6
hyperglycemia 5.5
CAM 5.5
AD2 5.4
potassium deficiency 5.4
LCS 5.3
glucose intolerance 5.3
hyperinsulinemia 5.2
kidney hypertrophy 5.2
MODY 5.2
KMS 5.2
Buchanan 5.1
ketosis 5.1
vitamin B6 deficiency 5.0
prolonged pregnancy 5.0
KMS 4.9
wasting syndrome 4.9
Enzyme inhibition 4.9
hypoglycemia 4.9
overnutrition 4.8
chlorosis 4.8
ACS1 4.8
endotoxic shock 4.7
PRS 4.7
tapeworm 4.7
beriberi 4.7
RDP 4.6
Spraying 4.6
lipodystrophy 4.6
idiopathic thrombocytopenic purpura 4.6
AIN 4.6
fatty liver 4.5
Copper deficiency 4.5
Hymenolepis 4.5
vitamin A deficiency 4.5
hepatic neoplasm 4.5
Adenovirus 4.4
type 2 diabetes 4.4
PER 4.3
DIG 4.3
fascioliasis 4.3
nutritional disorder 4.2
AOA 4.2
thiamine deficiency 4.2
hepatocellular carcinoma 4.2
FDH 4.2
magnesium deficiency 4.1
endocrine disorder 4.1
Chronic hepatitis C 4.1
Parry 4.0
clonorchiasis 4.0
taeniasis 4.0
LIP 3.9
renal tubular acidosis 3.9
yaws 3.9
mitochondrial encephalomyopathy 3.9
more...
Symptom
Tissue anoxia 10.6
loss of equilibrium 5.8
starvation 5.1
inanition 5.1
blackout 4.0
acidity 3.9
Decreased activity 3.8
Anoxia 3.8
acute stress 3.3
cachexia 3.2
polyuria 2.9
emaciation 2.8
polydipsia 2.8
hepatomegaly 2.4
exhaustion 2.3
tense 1.8
splenomegaly 1.2
anorexia 1.1
hyperoxia 0.5
thinning 0.4
sleepiness -0.8
fatigue -0.8
stigma -0.8
hypothermia -1.2
tremor -1.3
cough -1.7
overweight -1.8
anesthesia -1.9
vomiting -2.1
diarrhea -2.9
pain -4.1
Drug
Sulfopyruvate 10.6
Phenylphosphate 9.7
Cottonseed oil 9.1
p-Chlorophenyl 9.0
Citrus unshiu peel 8.8
Posilac 8.6
Aspartic Acid 7.7
Sodium sulfate 7.6
1-Deoxynojirimycin 7.2
Nipradilol 7.0
Vanilla 6.8
Pyridoxamine 6.7
Calan 6.6
Fructose 6.2
Glucagon 6.2
Rosiglitazone 6.2
Trilostane 6.1
Myricetin 5.6
Pentostam 5.5
Troglitazone 5.4
CAM 5.4
Carbenoxolone 5.3
Glycerol 5.2
Liraglutide 5.1
NADH 5.0
Rasburicase 4.9
CDX 4.9
Asparaginase 4.9
Isoptin 4.9
citric acid 4.8
CER 4.8
Aloe 4.6
Gemfibrozil 4.5
Colombo 4.5
Flavin 4.5
Enrofloxacin 4.5
Diurnal 4.5
CDX 4.5
Alanine 4.3
CoCl2 4.2
CoCl2 4.2
Aminoguanidine 4.2
Scopolamine 4.1
Valsartan 4.0
Emodin 4.0
Monensin 4.0
Growth hormone 3.9
Growth hormone 3.9
Glutamic acid 3.9
Citric acid 3.9
DNase I 3.9
DMI 3.8
Orphan 3.8
Salicylate 3.8
Clofibrate 3.7
Emodin 3.7
Dasatinib 3.6
Vitamin A 3.6
Vitamin B 3.6
Gel 3.4
Glycyrrhiza 3.4
Carotenoid 3.4
Riboflavin 3.3
CDP 3.3
AGG 3.3
Leaf 3.1
Forskolin 3.1
Adenosine triphosphate 3.1
DEX 3.0
NH3 2.9
PFA 2.9
Acyclovir 2.9
IL-11 2.8
G418 2.8
lysine 2.7
Capsicum 2.7
RFP 2.6
Vitamin B12 2.6
Arsenic trioxide 2.6
Fraction 2.6
more...
Enzyme
phosphoenolpyruvate carboxykinase 12.9
phosphoenolpyruvate carboxykinase 12.9
phosphoenolpyruvate carboxykinase 12.7
phosphoenolpyruvate carboxylase 12.6
EC 1.3.1.37 12.3
PEP phosphatase 12.2
L-idonate dehydrogenase 11.9
EC 4.1.1.40 11.9
PPDK 11.3
malyl-CoA lyase 10.6
CimA 10.6
pyruvate carboxylase 10.5
glucose-6-phosphatase 10.2
phosphoenolpyruvate synthase 10.2
oxaloacetate decarboxylase 10.0
fructose 1,6-bisphosphatase 9.9
malate thiokinase 9.6
EC 1.1.1.82 9.5
nucleotide 3'-pyrophosphokinase 9.4
UGT85B1 9.4
EC 1.1.1.38 9.4
triokinase 9.3
glycine dehydrogenase 9.2
glycine dehydrogenase 9.2
rubisco 9.2
aldose-6-phosphate reductase 9.1
glucokinase 9.0
pyruvate kinase 8.9
EC 1.1.1.40 8.9
glutaminase II 8.8
sucrose-phosphatase 8.7
isocitrate lyase 8.6
malate dehydrogenase 8.6
propionate kinase 8.6
citrate cleavage enzyme 8.6
glycine dehydrogenase 8.5
carbamoylphosphate synthetase 8.5
hydroxypyruvate reductase 8.4
glycerate kinase 8.4
EC 2.6.1.4 8.4
GapB 8.3
tyrosine aminotransferase 8.3
hydroxypyruvate reductase 8.3
acetate kinase 8.2
glycerol kinase 8.1
citrate lyase 8.1
AIR synthetase 8.1
glycolate dehydrogenase 8.1
malate synthase 8.0
pyruvate:ferredoxin oxidoreductase 8.0
trehalose phosphate synthase 8.0
6-phosphofructo-2-kinase 8.0
glutamate synthase 7.9
fumarase 7.9
glycine decarboxylase 7.9
glutamate synthase 7.9
SBPase 7.8
diaminopimelate dehydrogenase 7.8
citramalate synthase 7.8
propionyl-CoA carboxylase 7.8
propionyl-CoA carboxylase 7.8
ferric chelate reductase 7.8
glutamate synthase 7.8
12-oxophytodienoate reductase 7.8
carboxypeptidase S 7.7
transcarboxylase 7.7
diaminopimelate decarboxylase 7.7
acetyl-CoA synthetase 7.7
dihydroxyacetone kinase 7.6
fumarate reductase 7.6
phosphofructokinase 7.6
aspartokinase 7.6
NADPH:quinone oxidoreductase 7.6
mannitol 1-phosphate dehydrogenase 7.6
glycerol 3-phosphate dehydrogenase 7.6
EC 1.1.1.39 7.5
ornithine cyclodeaminase 7.5
argininosuccinate synthetase 7.5
isocitrate dehydrogenase 7.4
ABA2 7.4
more...
Compound
Perfluorosuccinate 12.9
Glyoxal bisulfite 12.9
Ethyl bromopyruvate 12.9
Linderane 12.9
Diethyl oxaloacetate 11.9
Hydrocortisone phosphate 11.3
Potassium sulfate 10.6
Potassium sulfate 10.6
Gentianine 10.3
3-MPA 10.0
Hydrazine sulfate 10.0
o-Iodosobenzoate 9.9
3-sulfopyruvate 9.7
Phenylphosphate 9.7
Ribose 5-phosphate 9.7
N-formimino-l-glutamate 9.6
oxalacetate 9.5
Butylamine 9.2
IDP 8.8
PEP 8.7
Malate 8.7
Amarogentin 8.6
1-Anilinonaphthalene 8.5
Trehalose-6-phosphate 8.2
6-fluorotryptophan 8.1
Glucose 6-phosphate 8.1
6-phosphogluconolactone 8.0
Pyruvate kinase 7.9
dCDP 7.9
GW 9662 7.8
Syringaldehyde 7.8
Ribulose 7.8
malic acid 7.6
mercaptopyruvate 7.5
propionyl-coenzyme A 7.5
Ectoine 7.5
dGDP 7.4
Sodium sulfate 7.4
Diosmin 7.4
Bromelia 7.4
4-fluorophenylalanine 7.4
Nialamide 7.4
Triamcinolone 7.3
2-phosphoglycerate 7.2
Myricitrin 7.2
Phenelzine 7.2
glucose-6-phosphate 7.2
Phenelzine 7.1
Glyoxylate 7.1
2,3-dimercapto-1-propanol 7.1
2,3-dimercapto-1-propanol 7.1
Beclomethasone 7.1
Eupatilin 7.0
Quinolinic acid 7.0
malic acid 7.0
malic acid 7.0
malic acid 7.0
Pyruvate 6.9
ADP-glucose 6.8
Azocoll 6.8
Glabridin 6.7
thieno[2,3-b]pyridine 6.7
Acetyl phosphate 6.7
CONV 6.7
Dibutyryl cyclic AMP 6.7
2-Oxoglutarate 6.7
Dibutyryl cyclic AMP 6.7
Pyridoxamine 6.7
NPR 6.6
2-amino-2-methyl-1-propanol 6.6
acetyl-CoA 6.6
Glycerate 6.6
Succinyl-CoA 6.6
D-xylulose-5-phosphate 6.6
2-decenoic acid 6.6
NADP 6.5
2-amino-2-methyl-1-propanol 6.5
D-glucose 1-phosphate 6.5
Metalaxyl 6.5
Fumarate 6.5
more...