Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:4.1.1.32 (phosphoenolpyruvate carboxykinase)
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Human Gene/Protein
Hepatic nuclear factor 4 alpha 12.9
phosphoenolpyruvate carboxykinase 12.8
phosphoenolpyruvate carboxylase 12.7
PEPCK-C 12.3
PEPCK-M 12.2
pyruvate carboxylase, mitochondrial 11.9
zinc finger homeodomain protein 11.9
PCK1 11.6
PCK2 11.6
NADP-malic enzyme 11.6
TCDD-inducible poly(ADP-ribose) polymerase 11.3
NAD-malic enzyme 11.2
NAD-ME 11.1
PEPCK 11.1
MRP-S9 10.9
NADP-ME 10.8
cytochrome c-1 10.6
pyruvate carboxylase 10.5
TSE1 10.3
Glutamic dehydrogenase 10.3
CPS1 protein 10.3
glucose-6-phosphatase 10.2
carboxylating 10.2
fructose-bisphosphatase 10.1
dihydrolipoamide S-succinyltransferase 10.1
APC2 protein 10.1
fructose 1,6-bisphosphatase 10.0
phosphoenolpyruvate carboxykinase 2 9.9
Forkhead/winged helix transcription factor 9.9
AREBP 9.9
PDE3B protein 9.9
Tissue-specific extinguisher 1 9.7
glycerokinase 9.7
Fructose-bisphosphate aldolase 9.7
NADP-dependent malic enzyme 9.7
pyruvate kinase L 9.6
fructose-1,6-bisphosphatase 9.6
Fructose 1,6-bisphosphatase 9.6
G6Pase 9.5
Pyruvate carboxylase 9.5
1-acylglycerol-3-phosphate O-acyltransferase 2 9.4
phosphorylase, glycogen 9.4
ZFP91 9.3
RFWD2 9.3
carbamoylphosphate synthetase I 9.3
ZHX3 9.3
Malic enzyme 9.2
ME5 9.2
S171 9.2
fructose-1,6-bisphosphatase 1 9.1
serine dehydratase 9.1
constitutive heat shock protein 70 9.1
succinate dehydrogenase flavoprotein subunit 9.1
Glucose-6-phosphatase 9.1
liver glycogen synthase 9.1
ESA1 9.0
CAT5 9.0
pck2 9.0
FEEL-1 9.0
glycine dehydrogenase 9.0
glucokinase 9.0
FBP1 8.9
pyruvate kinase 8.9
GSD1a 8.9
6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 8.9
decarboxylating 8.9
IDP 8.8
phosphate-activated glutaminase 8.8
DOC1 8.8
PFK-2/FBPase-2 8.8
APOC4 8.8
Malate dehydrogenase 8.8
malate dehydrogenase 8.8
MDH2 8.8
D-fructose-1,6-bisphosphate 1-phosphohydrolase 8.7
RGPR-p117 8.7
SLC27A2 8.7
tubulin beta chain 8.7
BHLHE40 8.7
SLC38A3 8.6
ATP-binding cassette transporter-1 8.6
DDF1 8.6
protein-serine/threonine kinase 8.6
NADH dehydrogenase subunit 1 8.6
asialoglycoprotein receptor 1 8.6
CL-6 8.5
CRTC2 8.5
6-phosphofructokinase 8.4
very long-chain acyl-CoA synthetase 8.4
MAEA 8.4
KCNJ15 8.4
SWP1 8.4
insulin-like peptide 5 8.4
PEP 8.4
NAD-dependent glyceraldehyde-3-phosphate dehydrogenase 8.4
Phosphoserine phosphatase 8.4
insulin receptor substrate-2 8.3
Glycolate oxidase 8.3
p102 8.3
glycerate kinase 8.3
NFI-A 8.3
cyclin I 8.3
phosphoglyceromutase 8.3
sterol regulatory element-binding protein-1c 8.3
L-alpha-glycerophosphate dehydrogenase 8.2
SLA1 8.2
glucose-6-phosphate 1-dehydrogenase 8.2
HIG1 8.2
PHT2 8.2
hydroxypyruvate reductase 8.2
carnitine palmitoyltransferase 1A 8.2
fumarase 8.2
Cytochrome c oxidase subunit I 8.2
EHHADH 8.2
BDH2 8.2
FBPase 8.2
CTLH 8.1
carbamoylphosphate synthetase 8.1
cAMP responsive element binding protein 1 8.1
SRCAP 8.1
6-phosphofructo-2-kinase 8.0
phosphofructokinase 1 8.0
Spot14 8.0
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 8.0
glycine decarboxylase 8.0
CRBP-II 8.0
aquaporin 9 8.0
DFF35 8.0
5-methyltetrahydrofolate-homocysteine methyltransferase 8.0
aldolase B 7.9
Pyruvate kinase 7.9
PKL 7.9
AIRS 7.9
serine/threonine kinase 2 7.9
liver glycogen phosphorylase 7.9
argininosuccinate synthetase 7.9
NADH dehydrogenase subunit 5 7.8
Glucokinase 7.8
propionyl-CoA carboxylase 7.8
Phosphoglycerate dehydrogenase 7.8
flotillin 2 7.8
G6PC3 7.8
CACT 7.8
Kir4.2 7.8
PPP1R3B 7.8
CCAAT-binding transcription factor 7.8
protein serine kinase 7.8
SREBP-1a 7.7
Protein-tyrosine phosphatase 1B 7.7
ceruloplasmin mRNA 7.7
pyruvate dehydrogenase kinase 4 7.7
D-site binding protein 7.7
CYP46 7.7
PSPH 7.7
COX4I2 7.7
C/EBP alpha 7.7
Phosphoglycerate kinase 7.7
tryptophan oxygenase 7.6
hepatocyte nuclear factor 1 alpha 7.6
thyroid hormone receptor-associated protein 7.6
more...
Disease
Glucagon resistance 10.9
Avian reticuloendotheliosis 10.6
ALAD deficiency 9.0
Brain mass 8.7
Fasting hypoglycemia 8.1
Biotin deficiency 7.9
CPS deficiency 7.6
Paxton 7.6
Hers 7.2
porcine stress syndrome 7.0
Benson 6.8
Mohr 6.7
PNP deficiency 6.6
disorders of amino acid metabolism 6.6
MODY1 6.4
PDH deficiency 6.4
coenurosis 6.3
diphyllobothriasis 6.1
diabetic hyperglycemia 6.0
AD1 6.0
orotic aciduria 6.0
hepatic porphyria 6.0
Jejunum 5.8
postmaturity 5.7
lymphoblastoma 5.6
hyperglycemia 5.5
CAM 5.5
AD2 5.4
potassium deficiency 5.4
LCS 5.3
glucose intolerance 5.3
hyperinsulinemia 5.2
kidney hypertrophy 5.2
MODY 5.2
KMS 5.2
Buchanan 5.1
ketosis 5.1
vitamin B6 deficiency 5.0
prolonged pregnancy 5.0
KMS 4.9
wasting syndrome 4.9
Enzyme inhibition 4.9
hypoglycemia 4.9
overnutrition 4.8
chlorosis 4.8
ACS1 4.8
endotoxic shock 4.7
PRS 4.7
tapeworm 4.7
beriberi 4.7
RDP 4.6
Spraying 4.6
lipodystrophy 4.6
idiopathic thrombocytopenic purpura 4.6
AIN 4.6
fatty liver 4.5
Copper deficiency 4.5
Hymenolepis 4.5
vitamin A deficiency 4.5
hepatic neoplasm 4.5
Adenovirus 4.4
type 2 diabetes 4.4
PER 4.3
DIG 4.3
fascioliasis 4.3
nutritional disorder 4.2
AOA 4.2
thiamine deficiency 4.2
hepatocellular carcinoma 4.2
FDH 4.2
magnesium deficiency 4.1
endocrine disorder 4.1
Chronic hepatitis C 4.1
Parry 4.0
clonorchiasis 4.0
taeniasis 4.0
LIP 3.9
renal tubular acidosis 3.9
yaws 3.9
mitochondrial encephalomyopathy 3.9
immune disorder 3.8
metabolic alkalosis 3.7
FAS 3.7
MLS 3.7
intestinal cancer 3.6
hyperphagia 3.6
juvenile periodontitis 3.6
KNO 3.6
Korsakoff's syndrome 3.6
PDP 3.6
NSD 3.6
SPS 3.5
reticuloendotheliosis 3.5
PCC 3.5
sudden infant death syndrome 3.5
dyslipidemia 3.4
lactic acidosis 3.4
metabolic disorder 3.4
iron deficiency 3.4
HEP 3.4
porphyria 3.4
Leigh syndrome 3.4
lipoatrophy 3.4
BCH 3.4
lipidosis 3.3
systemic candidiasis 3.3
multiple disorders 3.3
Schistosoma mansoni 3.2
PDC 3.2
CLN3 3.2
PCT 3.2
metabolic syndrome 3.2
seminal vesicles 3.2
NPH 3.2
porphyria cutanea tarda 3.1
SPS 3.1
metritis 3.1
PSP 3.1
ABS 3.1
neonatal jaundice 3.1
SCS 3.1
alcoholic fatty liver 3.1
HTS 3.0
HCA 3.0
adrenal hyperplasia 3.0
ABS 3.0
maple syrup urine disease 3.0
BSE 3.0
Robinson 3.0
mole 2.9
DMS 2.9
Anisakis 2.9
PGA 2.9
diabetes 2.9
LBD 2.8
PIC 2.8
PAL 2.8
vitreous humor 2.8
hyperlipidemia 2.7
obesity 2.7
pH increased 2.7
mole 2.7
megacolon 2.7
insulinoma 2.6
schistosomiasis 2.6
glycogen storage disease 2.5
EPS 2.5
Esophageal squamous cell carcinoma 2.5
parasitic disease 2.5
retinopathy of prematurity 2.4
Echinococcus 2.4
INS 2.4
Fox 2.4
pheochromocytoma 2.4
African trypanosomiasis 2.4
Mitchell 2.4
EPS 2.4
petechiae 2.3
MICA 2.3
respiratory acidosis 2.3
more...
Symptom
Tissue anoxia 10.6
loss of equilibrium 5.8
starvation 5.1
inanition 5.1
blackout 4.0
acidity 3.9
Decreased activity 3.8
Anoxia 3.8
acute stress 3.3
cachexia 3.2
polyuria 2.9
emaciation 2.8
polydipsia 2.8
hepatomegaly 2.4
exhaustion 2.3
tense 1.8
splenomegaly 1.2
anorexia 1.1
hyperoxia 0.5
thinning 0.4
sleepiness -0.8
fatigue -0.8
stigma -0.8
hypothermia -1.2
tremor -1.3
cough -1.7
overweight -1.8
anesthesia -1.9
vomiting -2.1
diarrhea -2.9
pain -4.1
Drug
Sulfopyruvate 10.6
Phenylphosphate 9.7
Cottonseed oil 9.1
p-Chlorophenyl 9.0
Citrus unshiu peel 8.8
Posilac 8.6
Aspartic Acid 7.7
Sodium sulfate 7.6
1-Deoxynojirimycin 7.2
Nipradilol 7.0
Vanilla 6.8
Pyridoxamine 6.7
Calan 6.6
Fructose 6.2
Glucagon 6.2
Rosiglitazone 6.2
Trilostane 6.1
Myricetin 5.6
Pentostam 5.5
Troglitazone 5.4
CAM 5.4
Carbenoxolone 5.3
Glycerol 5.2
Liraglutide 5.1
NADH 5.0
Rasburicase 4.9
CDX 4.9
Asparaginase 4.9
Isoptin 4.9
citric acid 4.8
CER 4.8
Aloe 4.6
Gemfibrozil 4.5
Colombo 4.5
Flavin 4.5
Enrofloxacin 4.5
Diurnal 4.5
CDX 4.5
Alanine 4.3
CoCl2 4.2
CoCl2 4.2
Aminoguanidine 4.2
Scopolamine 4.1
Valsartan 4.0
Emodin 4.0
Monensin 4.0
Growth hormone 3.9
Growth hormone 3.9
Glutamic acid 3.9
Citric acid 3.9
DNase I 3.9
DMI 3.8
Orphan 3.8
Salicylate 3.8
Clofibrate 3.7
Emodin 3.7
Dasatinib 3.6
Vitamin A 3.6
Vitamin B 3.6
Gel 3.4
Glycyrrhiza 3.4
Carotenoid 3.4
Riboflavin 3.3
CDP 3.3
AGG 3.3
Leaf 3.1
Forskolin 3.1
Adenosine triphosphate 3.1
DEX 3.0
NH3 2.9
PFA 2.9
Acyclovir 2.9
IL-11 2.8
G418 2.8
lysine 2.7
Capsicum 2.7
RFP 2.6
Vitamin B12 2.6
Arsenic trioxide 2.6
Fraction 2.6
Honey 2.5
Ethanol 2.4
Asn 2.4
lactose 2.3
balanced salt solution 2.3
Triclosan 2.3
TAC 2.2
Retinoic acid 2.2
Kenyan 2.1
PTC 2.1
Itraconazole 1.9
Theophylline 1.9
Portal 1.8
PCB 1.8
ROS 1.8
ascorbate 1.7
TAT 1.7
pyridoxal phosphate 1.6
MAP 1.5
ALA 1.4
Bifidobacterium 1.4
Mutagen 1.3
Heme 1.3
Atropine 1.2
MRC 1.1
niacin 1.0
THF 0.9
ABC 0.8
Albumin 0.7
Glutathione 0.5
caffeine 0.5
FAD 0.5
Indomethacin 0.3
CaCl2 0.3
CaCl2 0.3
CaCl2 0.2
PTH 0.2
EPA 0.1
EE2 -0.0
Nephron -0.7
ampicillin -1.1
Monit -1.2
vitamin E -1.2
Nephron -1.2
Asthma -1.8
IL-2 -1.9
Dermatol -5.1
Enzyme
phosphoenolpyruvate carboxykinase 12.9
phosphoenolpyruvate carboxykinase 12.9
phosphoenolpyruvate carboxykinase 12.7
phosphoenolpyruvate carboxylase 12.6
EC 1.3.1.37 12.3
PEP phosphatase 12.2
L-idonate dehydrogenase 11.9
EC 4.1.1.40 11.9
PPDK 11.3
CimA 10.6
malyl-CoA lyase 10.6
pyruvate carboxylase 10.5
glucose-6-phosphatase 10.2
phosphoenolpyruvate synthase 10.2
oxaloacetate decarboxylase 10.0
fructose 1,6-bisphosphatase 9.9
malate thiokinase 9.6
EC 1.1.1.82 9.5
UGT85B1 9.4
EC 1.1.1.38 9.4
nucleotide 3'-pyrophosphokinase 9.4
triokinase 9.3
glycine dehydrogenase 9.2
glycine dehydrogenase 9.2
rubisco 9.2
aldose-6-phosphate reductase 9.1
glucokinase 9.0
pyruvate kinase 8.9
EC 1.1.1.40 8.9
glutaminase II 8.8
sucrose-phosphatase 8.7
isocitrate lyase 8.6
malate dehydrogenase 8.6
propionate kinase 8.6
citrate cleavage enzyme 8.6
glycine dehydrogenase 8.5
carbamoylphosphate synthetase 8.5
hydroxypyruvate reductase 8.4
glycerate kinase 8.4
EC 2.6.1.4 8.4
GapB 8.3
tyrosine aminotransferase 8.3
hydroxypyruvate reductase 8.3
acetate kinase 8.2
glycerol kinase 8.1
citrate lyase 8.1
AIR synthetase 8.1
glycolate dehydrogenase 8.1
malate synthase 8.0
pyruvate:ferredoxin oxidoreductase 8.0
trehalose phosphate synthase 8.0
6-phosphofructo-2-kinase 8.0
glutamate synthase 7.9
fumarase 7.9
glycine decarboxylase 7.9
glutamate synthase 7.9
diaminopimelate dehydrogenase 7.8
SBPase 7.8
citramalate synthase 7.8
propionyl-CoA carboxylase 7.8
propionyl-CoA carboxylase 7.8
ferric chelate reductase 7.8
glutamate synthase 7.8
12-oxophytodienoate reductase 7.8
carboxypeptidase S 7.7
transcarboxylase 7.7
diaminopimelate decarboxylase 7.7
acetyl-CoA synthetase 7.7
dihydroxyacetone kinase 7.6
fumarate reductase 7.6
phosphofructokinase 7.6
aspartokinase 7.6
mannitol 1-phosphate dehydrogenase 7.6
NADPH:quinone oxidoreductase 7.6
glycerol 3-phosphate dehydrogenase 7.6
EC 1.1.1.39 7.5
ornithine cyclodeaminase 7.5
argininosuccinate synthetase 7.5
isocitrate dehydrogenase 7.4
desulfinase 7.4
ABA2 7.4
pyruvate formate-lyase 7.3
phosphoglycolate phosphatase 7.3
dihydrodipicolinate reductase 7.3
EC 2.4.1.11 7.3
EC 1.7.7.1 7.2
glutaminase 7.2
AMP-activated kinase 7.2
fatty-acid synthase 7.2
sucrose synthase 7.2
methylglyoxal synthase 7.2
3-hydroxybutyryl-CoA dehydrogenase 7.2
chlorophyllase 7.1
oxoglutarate dehydrogenase 7.1
nucleoside diphosphokinase 7.1
isocitrate dehydrogenase 7.1
glutamate dehydrogenase 7.1
glutamate dehydrogenase 7.1
asparagine synthetase 7.1
glutamic dehydrogenase 7.1
glutamate dehydrogenase 7.1
ribose-5-phosphate isomerase 7.1
allantoicase 7.1
L-serine dehydratase 7.1
phosphofructokinase 1 7.0
acetyl-CoA carboxylase 7.0
alpha-ketoglutarate dehydrogenase 7.0
citrate synthase 7.0
EC 2.7.7.9 7.0
fructokinase 7.0
hexokinase 6.9
EC 1.1.1.47 6.9
phosphoglyceromutase 6.9
6-phosphogluconate dehydrogenase 6.8
6-phosphogluconate dehydrogenase 6.8
glutamine synthetase 6.8
pyruvate dehydrogenase 6.8
argininosuccinate lyase 6.8
HMG-CoA synthase 6.8
pyruvate dehydrogenase 6.8
10-formyltetrahydrofolate dehydrogenase 6.8
Mg-chelatase 6.8
ADP-glucose pyrophosphorylase 6.8
dihydrolipoamide succinyltransferase 6.7
tryptophan 2,3-dioxygenase 6.7
phosphoribulokinase 6.7
threonine synthase 6.6
aconitase 6.6
biotin carboxylase 6.6
branched-chain aminotransferase 6.6
octopine dehydrogenase 6.6
glyoxylate reductase 6.6
glyoxylate reductase 6.6
isoflavone reductase 6.6
transaldolase 6.6
phosphoglycerate kinase 6.6
pyruvate dehydrogenase 6.6
granule-bound starch synthase 6.5
dihydroxyacetone phosphate acyltransferase 6.5
glycerophosphodiester phosphodiesterase 6.4
6-phosphogluconolactonase 6.4
transhydrogenase 6.4
acyl-CoA oxidase 6.4
MDH 6.4
pyruvate dehydrogenase phosphatase 6.4
reductoisomerase 6.4
pyruvate oxidase 6.4
glycolate oxidase 6.4
pyruvate oxidase 6.4
glucose-6-phosphate dehydrogenase 6.4
CYP8B1 6.4
11beta-hydroxysteroid dehydrogenase 6.4
aromatic amino acid aminotransferase 6.4
beta-hydroxybutyrate dehydrogenase 6.3
phosphorylase 6.3
MDH 6.3
ornithine transcarbamylase 6.3
succinic dehydrogenase 6.3
3-oxoacid CoA-transferase 6.3
diacylglycerol acyltransferase 6.3
more...
Compound
Glyoxal bisulfite 12.9
Linderane 12.9
Perfluorosuccinate 12.9
Ethyl bromopyruvate 12.9
Diethyl oxaloacetate 11.9
Hydrocortisone phosphate 11.3
Potassium sulfate 10.6
Potassium sulfate 10.6
Gentianine 10.3
3-MPA 10.0
Hydrazine sulfate 10.0
o-Iodosobenzoate 9.9
Phenylphosphate 9.7
3-sulfopyruvate 9.7
Ribose 5-phosphate 9.7
N-formimino-l-glutamate 9.6
oxalacetate 9.5
Butylamine 9.2
IDP 8.8
PEP 8.7
Malate 8.7
Amarogentin 8.6
1-Anilinonaphthalene 8.5
Trehalose-6-phosphate 8.2
6-fluorotryptophan 8.1
Glucose 6-phosphate 8.1
6-phosphogluconolactone 8.0
Pyruvate kinase 7.9
dCDP 7.9
GW 9662 7.8
Syringaldehyde 7.8
Ribulose 7.8
malic acid 7.6
mercaptopyruvate 7.5
propionyl-coenzyme A 7.5
Ectoine 7.5
dGDP 7.4
Sodium sulfate 7.4
Diosmin 7.4
Bromelia 7.4
Nialamide 7.4
4-fluorophenylalanine 7.4
Triamcinolone 7.3
Myricitrin 7.2
2-phosphoglycerate 7.2
Phenelzine 7.2
glucose-6-phosphate 7.2
Glyoxylate 7.1
Phenelzine 7.1
2,3-dimercapto-1-propanol 7.1
2,3-dimercapto-1-propanol 7.1
Beclomethasone 7.1
Eupatilin 7.0
Quinolinic acid 7.0
malic acid 7.0
malic acid 7.0
malic acid 7.0
Pyruvate 6.9
ADP-glucose 6.8
Azocoll 6.8
thieno[2,3-b]pyridine 6.7
Glabridin 6.7
CONV 6.7
Acetyl phosphate 6.7
2-Oxoglutarate 6.7
Dibutyryl cyclic AMP 6.7
Dibutyryl cyclic AMP 6.7
Pyridoxamine 6.7
NPR 6.6
2-amino-2-methyl-1-propanol 6.6
acetyl-CoA 6.6
Glycerate 6.6
Succinyl-CoA 6.6
2-decenoic acid 6.6
D-xylulose-5-phosphate 6.6
NADP 6.5
2-amino-2-methyl-1-propanol 6.5
D-glucose 1-phosphate 6.5
Metalaxyl 6.5
Fumarate 6.5
pentose 6.5
pentose 6.5
Dihydroxyacetone 6.4
isocitrate 6.4
pentose 6.4
pentose 6.3
carbamyl phosphate 6.3
Tyrosol 6.3
ITP 6.3
EH2 6.3
5-fluorotryptophan 6.3
Glucagon 6.2
6-phosphogluconate 6.2
Steviol 6.2
Amytal 6.2
AICAR 6.2
2-oxoglutarate 6.2
Hesperidin 6.2
TCTP 6.2
Phlorizin 6.2
Fructose 6.2
hexacosanoic acid 6.2
mannitol-1-phosphate 6.2
Chlorophyll 6.2
succinic acid 6.1
2-oxoadipate 6.1
STZ 6.1
glutaryl-CoA 6.1
Bisphenol S 6.0
2,4-pentanedione 6.0
2,4-pentanedione 6.0
adenylosuccinate 6.0
2,4-pentanedione 6.0
2,4-pentanedione 6.0
2,4-pentanedione 6.0
2,4-pentanedione 6.0
succinic acid 5.9
succinic acid 5.9
succinic acid 5.9
succinic acid 5.9
G3P 5.9
2,4-pentanedione 5.9
2,4-pentanedione 5.9
2,4-pentanedione 5.9
2,4-pentanedione 5.9
2,4-pentanedione 5.9
Zeatin 5.9
2,4-pentanedione 5.9
2,4-pentanedione 5.9
Roxarsone 5.9
2,4-pentanedione 5.9
HCO 5.9
Glycogen 5.9
Catalpol 5.9
Propionate 5.8
DXP 5.8
1,2-dichloroethylene 5.7
Benzothiazole 5.7
O-acetylserine 5.7
Glutamine 5.7
1,2-dichloroethylene 5.7
Glycine, 5.7
2-oxobutyrate 5.6
Malonate 5.6
Geniposide 5.6
Flux 5.6
malonyl-CoA 5.6
IBP 5.6
IBP 5.6
O-acetylserine 5.6
alloxan 5.6
acetylglutamate 5.5
1,3-butanediol 5.5
TCA 5.5
Equol 5.5
Glycyrrhetinic acid 5.5
PNU 5.5
Chlorophyll a 5.4
1,2-cyclohexanedione 5.4
ATF 5.4
more...