Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:4.1.1.32 (phosphoenolpyruvate carboxykinase)
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Human Gene/Protein
phosphoenolpyruvate carboxykinase 2811
phosphoenolpyruvate carboxylase 1280
insulin 863
glucose-6-phosphatase 481
pyruvate kinase 332
Mol 309
Sep 301
pyruvate carboxylase 279
glucagon 239
CO2 231
ATP 225
malate dehydrogenase 215
glucokinase 188
PEPCK 168
phosphatase 150
AMP 143
NADP 123
NAD 106
lactate dehydrogenase 106
fructose-1,6-bisphosphatase 98
PEP 97
NADH 96
NADP-malic enzyme 90
aspartate aminotransferase 89
Bot 86
phosphofructokinase 84
hexokinase 83
glucocorticoid receptor 83
fatty acid synthase 82
glucose transporter 81
PCK1 81
peroxisome proliferator-activated receptor 80
glutamate dehydrogenase 79
ADP 79
GTP 78
glutamine synthetase 75
citrate synthase 72
NADPH 67
insulin receptor 65
PEPCK-C 65
glucose-6-phosphate dehydrogenase 63
glycogen synthase 62
leptin 59
alanine aminotransferase 59
isocitrate dehydrogenase 57
growth hormone 56
IRS-1 54
pyruvate dehydrogenase 52
AMP-activated protein kinase 51
NMR 51
TAT 50
G6Pase 50
polypeptide 49
albumin 48
acetyl-CoA carboxylase 48
TCA 48
glycogen phosphorylase 47
protein kinase B 47
carbonic anhydrase 47
fructose 1,6-bisphosphatase 46
catalase 46
NAD-malic enzyme 45
superoxide dismutase 43
rhabdomyosarcoma 41
peroxisome proliferator-activated receptor gamma 41
proximal tubule 39
EBP 39
PGC 39
ATPase 38
fused 38
lipoprotein lipase 37
glutaminase 33
CAM 32
Pyruvate carboxylase 32
GDP 32
glyceraldehyde-3-phosphate dehydrogenase 32
reductase 30
AKT 30
carboxylating 30
fumarase 29
hemoglobin 29
cytokine 29
TNF 29
epididymal 29
CREB 28
decarboxylating 28
threonine 28
nuclear receptor 28
NADP-ME 27
PCK2 27
metallothionein 27
adiponectin 26
tumor necrosis factor 26
AMPK 25
casein 24
SDS 24
insulin-like growth factor 24
phosphatidylinositol 3-kinase 24
glycolytic enzyme 24
Gen 23
GLUT4 23
6-phosphogluconate dehydrogenase 22
carnitine palmitoyltransferase 22
NAD-ME 22
STZ 22
Pseudomonas 22
alcohol dehydrogenase 22
histone 21
NAD+ 21
thyroid hormone 21
ubiquitin 20
aconitase 20
glucose transporter 4 20
enolase 20
phosphate-activated glutaminase 20
HDL 20
endoplasmic reticulum 20
cAMP-response element 19
phosphoglycerate kinase 19
sterol regulatory element-binding protein 19
IL-6 18
SHP 18
collagen 18
PEPCK-M 18
IDP 18
mTOR 18
adenylate kinase 17
IGF-I 17
C/EBP alpha 17
phosphodiesterase 17
lipopolysaccharide 17
forkhead transcription factor 17
protein phosphatase 17
thymidine kinase 17
PI3K 16
transferrin 16
hormone-sensitive lipase 16
glycine decarboxylase 16
nuclear protein 16
ACL 16
phosphoinositide 3-kinase 16
housekeeping 16
glycerol kinase 16
alkaline phosphatase 16
DNase I 16
nitric oxide synthase 15
calmodulin 15
cAMP response element-binding protein 15
Glucose-6-phosphatase 15
carbamoylphosphate synthetase 15
insulin receptor substrate 15
LL) 15
GLUT1 15
RNA polymerase II 15
argininosuccinate synthetase 15
cytochrome P450 14
glutathione peroxidase 14
ornithine transcarbamylase 14
HSD1 14
serine dehydratase 14
more...
Disease
diabetes 265
hyperglycemia 176
hepatocellular carcinoma 174
type 2 diabetes 163
obesity 110
hypoglycemia 81
glucose intolerance 61
hyperinsulinemia 53
tumor 46
cancer 44
fatty liver 43
CAM 33
metabolic syndrome 29
cold 26
SDS 24
idiopathic thrombocytopenic purpura 21
dyslipidemia 20
mole 18
mole 18
depression 18
hypertension 15
Mycobacterium 14
hyperlipidemia 14
Benson 12
tuberculosis 11
sepsis 11
dehydration 11
sepsis 11
hyperphagia 10
GSH 10
iron deficiency 10
pheochromocytoma 10
Adenovirus 9
Schistosoma mansoni 9
PCC 9
ketosis 9
type 1 diabetes 8
chlorosis 8
herpes simplex 7
FAS 7
tapeworm 7
lipodystrophy 7
schistosomiasis 7
tumor growth 7
metabolic disorder 7
Evans 7
leukemia 6
malnutrition 6
worms 6
lactic acidosis 6
ischemia 6
Echinococcus 6
vitamin A deficiency 6
cardiovascular disease 6
sudden infant death syndrome 6
malaria 5
Brown 5
AIN 5
pertussis 5
renal disease 5
wasting syndrome 5
virus infection 5
liver cancer 5
West 5
liver disease 5
tumorigenesis 5
carcinogenesis 5
endotoxic shock 5
infectious diseases 5
renal tubular acidosis 4
chronic renal failure 4
seminal vesicles 4
Chagas 4
Mohr 4
HIV 4
breast cancer 4
Hymenolepis 4
cytomegalovirus 4
hyperthyroidism 4
fits 4
alcoholic fatty liver 4
Infection 4
PDB 4
overnutrition 4
PER 3
hepatitis B 3
diabetic nephropathy 3
carcinoma 3
lung cancer 3
endocrine disorder 3
hepatitis C 3
multiple myeloma 3
thiamine deficiency 3
fascioliasis 3
colon cancer 3
cholestasis 3
hepatitis 3
atherosclerosis 3
liver cancer 3
wasting 3
Syndrome 3
Pituitary 3
neuroblastoma 3
metabolic alkalosis 3
Mycoplasma 3
polycystic ovary syndrome 3
melanoma 3
PGA 3
gestational diabetes mellitus 3
cerebral ischemia 3
insulinoma 3
hypothyroidism 2
Recruitment 2
adrenal insufficiency 2
epilepsy 2
leprosy 2
Leigh syndrome 2
chronic hepatitis 2
Chronic hepatitis C 2
ash 2
suicide 2
KMS 2
immunodeficiency 2
chronic disease 2
SEM 2
hepatic porphyria 2
zoonosis 2
tumor progression 2
rheumatoid arthritis 2
Biotin deficiency 2
sarcoma 2
porphyria cutanea tarda 2
Cryptococcus neoformans 2
pH increased 2
stroke 2
NAME 2
immunopathology 2
Brucella abortus 2
KMS 2
infestation 2
Blocking 2
retinopathy of prematurity 2
cirrhosis 2
arthritis 2
potassium deficiency 2
porphyria 2
MODY 2
peritonitis 2
Robinson 2
Alzheimer's disease 2
vagina 2
AD1 2
brucellosis 2
adenocarcinoma 2
African trypanosomiasis 2
inflammatory bowel disease 2
mammary tumor 2
diabetic hyperglycemia 2
non-small cell lung cancer 2
magnesium deficiency 2
more...
Symptom
starvation 116
acidity 30
exhaustion 9
cachexia 7
acute stress 6
anorexia 4
anesthesia 4
fatigue 4
hepatomegaly 4
splenomegaly 3
polyuria 3
pain 2
polydipsia 2
thinning 2
diarrhea 1
sleepiness 1
cough 1
loss of equilibrium 1
blackout 1
hypothermia 1
Tissue anoxia 1
overweight 1
Anoxia 1
emaciation 1
inanition 1
tense 1
Decreased activity 1
tremor 1
vomiting 1
hyperoxia 1
stigma 1
Drug
NADH 95
lysine 52
Glucagon 37
citric acid 37
CAM 32
Leaf 25
Gel 21
Fructose 19
DNase I 16
Glycerol 11
lactose 11
ascorbate 10
ROS 9
Asn 8
Rosiglitazone 8
Alanine 7
NH3 7
Ethanol 7
Growth hormone 6
MAP 6
Growth hormone 6
Diurnal 5
Vitamin A 5
Aloe 4
caffeine 4
DMI 4
CoCl2 3
Forskolin 3
Troglitazone 3
Scopolamine 3
CDP 3
CoCl2 3
Bifidobacterium 2
Kenyan 2
Glycyrrhiza 2
ABC 2
Monit 2
G418 2
Myricetin 2
Monensin 2
Liraglutide 2
Capsicum 2
Posilac 2
Vanilla 2
Fraction 2
Retinoic acid 2
THF 2
Portal 2
PCB 2
Vitamin B 2
Mutagen 2
Citrus unshiu peel 1
Itraconazole 1
Emodin 1
Colombo 1
Aspartic Acid 1
Pentostam 1
TAT 1
niacin 1
Albumin 1
Honey 1
Phenylphosphate 1
Rasburicase 1
Salicylate 1
Glutathione 1
pyridoxal phosphate 1
1-Deoxynojirimycin 1
Trilostane 1
Riboflavin 1
EPA 1
CER 1
ampicillin 1
Adenosine triphosphate 1
IL-2 1
Carbenoxolone 1
balanced salt solution 1
Indomethacin 1
Calan 1
Asthma 1
PFA 1
Gemfibrozil 1
Nephron 1
DEX 1
Dermatol 1
Theophylline 1
AGG 1
Flavin 1
Sodium sulfate 1
Asparaginase 1
Triclosan 1
Orphan 1
Dasatinib 1
IL-11 1
CDX 1
CaCl2 1
CaCl2 1
Glutamic acid 1
Vitamin B12 1
Atropine 1
Cottonseed oil 1
CDX 1
Carotenoid 1
Clofibrate 1
Isoptin 1
PTC 1
p-Chlorophenyl 1
ALA 1
TAC 1
Sulfopyruvate 1
CaCl2 1
Enrofloxacin 1
Valsartan 1
vitamin E 1
Citric acid 1
FAD 1
EE2 1
Pyridoxamine 1
PTH 1
Nipradilol 1
Emodin 1
Heme 1
Aminoguanidine 1
Arsenic trioxide 1
Nephron 1
RFP 1
Acyclovir 1
MRC 1
Enzyme
phosphoenolpyruvate carboxykinase 4204
phosphoenolpyruvate carboxykinase 4143
phosphoenolpyruvate carboxykinase 4117
phosphoenolpyruvate carboxylase 1409
glucose-6-phosphatase 485
pyruvate kinase 336
pyruvate carboxylase 296
malate dehydrogenase 234
glucokinase 191
protein kinase 185
lactate dehydrogenase 109
rubisco 101
aspartate aminotransferase 98
fructose 1,6-bisphosphatase 97
phosphofructokinase 97
glucose-6-phosphate dehydrogenase 86
hexokinase 83
alanine aminotransferase 81
glutamate dehydrogenase 79
isocitrate dehydrogenase 79
glutamate dehydrogenase 79
glutamate dehydrogenase 79
glutamine synthetase 75
citrate synthase 75
pyruvate dehydrogenase 68
AMP-activated protein kinase 68
phosphorylase 59
isocitrate dehydrogenase 57
catalase 55
tyrosine aminotransferase 54
PPDK 52
isocitrate lyase 51
pyruvate dehydrogenase 51
pyruvate dehydrogenase 51
acetyl-CoA carboxylase 50
carbonic anhydrase 48
glyceraldehyde-3-phosphate dehydrogenase 47
superoxide dismutase 46
ATPase 44
glyceraldehyde-3-phosphate dehydrogenase 39
mitogen-activated protein kinase 38
glyceraldehyde-3-phosphate dehydrogenase 38
AMPK 38
lipoprotein lipase 37
glutaminase 37
fumarase 36
chloramphenicol acetyltransferase 36
CPT 36
succinate dehydrogenase 35
luciferase 35
glyceraldehyde-3-phosphate dehydrogenase 34
nitrate reductase 33
nitrate reductase 32
glyceraldehyde-3-phosphate dehydrogenase 32
nitrate reductase 32
nitrate reductase 32
nitrate reductase 32
nitrate reductase 32
aldolase 28
glycerol kinase 27
phosphoglycerate kinase 27
protein kinase C 25
glutamate synthase 25
phosphatidylinositol 3-kinase 25
AMPK 25
glutamate synthase 24
aconitase 23
glutamate synthase 23
alcohol dehydrogenase 23
alpha-ketoglutarate dehydrogenase 22
6-phosphogluconate dehydrogenase 22
6-phosphogluconate dehydrogenase 22
oxaloacetate decarboxylase 22
calcineurin 21
enolase 20
RNA polymerase 20
succinic dehydrogenase 18
malate synthase 18
ornithine transcarbamylase 18
acetate kinase 18
glycine decarboxylase 18
adenylate cyclase 17
alkaline phosphatase 17
adenylate kinase 17
phosphodiesterase 17
thymidine kinase 17
phosphoinositide 3-kinase 16
fumarate reductase 16
hormone-sensitive lipase 16
argininosuccinate synthetase 16
focal adhesion kinase 15
glycerol-3-phosphate dehydrogenase 15
peroxidase 15
glycerol-3-phosphate dehydrogenase 15
sucrose synthase 15
carbamoylphosphate synthetase 15
11beta-hydroxysteroid dehydrogenase 14
complex I 14
glutathione peroxidase 14
trypsin 14
EC 1.1.1.40 13
ACS 13
CPT 13
lipase 13
phosphoglucose isomerase 13
CPT 13
acetyl-CoA synthetase 12
tryptophan 2,3-dioxygenase 12
GSK 12
beta-glucuronidase 12
invertase 12
proteasome 12
ascorbate peroxidase 11
PDK1 11
collagenase 11
acyl-CoA oxidase 11
glutathione reductase 11
arginase 11
6-phosphofructo-2-kinase 11
propionyl-CoA carboxylase 10
citrate lyase 10
phosphoenolpyruvate synthase 10
propionyl-CoA carboxylase 10
CPS 10
aspartokinase 10
PTA 10
reverse transcriptase 10
ERK 9
NADPH oxidase 9
diaphorase 9
MDH 9
asparagine synthetase 9
MDH 9
PEP phosphatase 9
AMP-activated kinase 9
diacylglycerol acyltransferase 9
pyruvate:ferredoxin oxidoreductase 8
hydroxypyruvate reductase 8
hydroxypyruvate reductase 8
NO synthase 8
hydrogenase 8
ADP-glucose pyrophosphorylase 8
nitrogenase 8
phosphoglucomutase 8
transhydrogenase 8
NADPH oxidase 8
ornithine decarboxylase 8
hydrogenase 8
nitrite reductase 7
NADH dehydrogenase 7
acyl-CoA dehydrogenase 7
gamma-glutamyl transpeptidase 7
HMG-CoA synthase 7
nitrite reductase 7
cytochrome oxidase 7
phosphoribulokinase 7
phenylalanine hydroxylase 7
formate dehydrogenase 7
PGM 7
protein phosphatase 2A 7
more...
Compound
glucose 1534
phosphate 362
Dec 308
CO2 281
DNA 254
cAMP 226
ATP 225
water 198
glycerol 174
oxygen 172
nitrogen 160
alanine 160
glutamate 154
AMP 150
NADP 139
acetate 131
PEP 127
glutamine 126
NAD 126
Insulin 121
NAD 106
serine 101
NADH 95
sodium 88
ADP 83
ammonium 82
GTP 79
ADP 79
ADP 79
ammonia 76
pentose 72
pentose 72
pentose 72
urea 72
pentose 72
manganese 71
oxalacetate 71
2-oxoglutarate 71
acetyl-CoA 70
calcium 69
salt 69
NADPH 67
glucose-6-phosphate 67
NADPH 67
ethanol 62
lysine 62
Clin 59
malic acid 59
nitrate 56
CoA 56
TCA 53
Mg2+ 49
arginine 46
nicotinamide 43
sulfate 42
HCO 41
Asp 41
tyrosine 40
cysteine 39
hydrogen 39
threonine 38
proline 37
Glucagon 37
tryptophan 36
STZ 34
tryptophan 34
tryptophan 34
tryptophan 34
carbonate 33
galactose 33
CAM 33
leucine 33
hexose 33
GDP 33
retinoic acid 32
hexose 32
succinic acid 32
hexose 32
hexose 32
malic acid 32
malic acid 31
malic acid 31
Pyruvate 30
Malate 30
Lactate 30
NH2 30
TNF 29
methionine 29
iron 28
Gly 28
asparagine 28
Dexamethasone 28
cadmium 27
nitric oxide 27
Sucrose 27
His 27
potassium 25
alloxan 25
Phe 24
SDS 24
aspartic acid 24
phosphorus 22
alcohol dehydrogenase 22
aspartic acid 22
PEG 21
ITP 21
acetic acid 20
aspartic acid 19
isocitrate 19
aspartic acid 19
Fructose 19
succinic acid 18
succinic acid 18
succinic acid 18
succinic acid 18
glutamic acid 18
Glycogen 18
IDP 18
dicarboxylic acid 18
Carbon 17
zinc 17
methanol 17
H2O2 17
cobalt 16
Phytol 15
PEG 15
Phytol 15
Glutamate 15
Pyruvate kinase 14
Ile 14
Glutamine 14
CPT 13
oxalate 13
adenylate 13
copper 13
Chlorophyll 13
Glucose 6-phosphate 13
valine 13
CPT 13
CIT 13
Ribulose 12
isoleucine 12
malonyl-CoA 12
NO3 11
GSH 11
CAT 11
CAT 11
isoleucine 11
cyanide 11
palmitic acid 11
GAP 11
ATF 11
Flux 11
CAT 11
GSH 11
silver 10
PPi 9
Salt 9
xylose 9
HCl 8
more...