Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:4.1.1.17 (
ornithine decarboxylase
)
6,351
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
We have investigated and characterized a novel
ornithine decarboxylase
(
ODC
) related protein (ODCrp) also annotated as gm853. ODCrp shows 41% amino acid sequence identity with
ODC
and 38% with
ODC
antizyme inhibitor 1 (AZIN1). The
Odcrp
gene is selectively expressed in the epithelium of proximal tubuli of mouse kidney with higher expression in males than in females. Like
Odc
in mouse kidney,
Odcrp
is also androgen responsive with androgen receptor (AR)-binding loci within its regulatory region. ODCrp forms homodimers but does not heterodimerize with
ODC
. Although ODCrp contains 20 amino acid residues known to be necessary for the catalytic activity of
ODC
, no decarboxylase activity could be found with ornithine, lysine or arginine as substrates. ODCrp does not function as an AZIN, as it neither binds
ODC
antizyme 1 (OAZ1) nor prevents
OAZ
-mediated inactivation and degradation of
ODC
. ODCrp itself is degraded via ubiquination and mutation of Cys
363
(corresponding to Cys
360
of
ODC
) appears to destabilize the protein. Evidence for a function of ODCrp was found in
ODC
assays on lysates from transfected Cos-7 cells where ODCrp repressed the activity of endogenous
ODC
while Cys
363
Ala mutated ODCrp increased the enzymatic activity of endogenous
ODC
.
...
PMID:Characterization of an androgen-responsive, ornithine decarboxylase-related protein in mouse kidney. 2860 32
