Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:4.1.1.17 (
ornithine decarboxylase
)
6,351
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The eukaryotic translation initiation factor 4E (eIF4E) alters gene expression on multiple levels. In the cytoplasm, eIF4E acts in the rate-limiting step of translation initiation. In the nucleus, eIF4E facilitates nuclear export of a subset of mRNAs. Both of these functions contribute to eIF4E's ability to oncogenically transform cells. We report here that the homeodomain protein,
HOXA9
, is a positive regulator of eIF4E.
HOXA9
stimulates eIF4E-dependent export of cyclin D1 and
ornithine decarboxylase
(
ODC
) mRNAs in the nucleus, as well as increases the translation efficiency of
ODC
mRNA in the cytoplasm. These activities depend on direct interactions of
HOXA9
with eIF4E and are independent of the role of
HOXA9
in transcription. At the biochemical level,
HOXA9
mediates these effects by competing with factors that repress eIF4E function, in particular the proline-rich homeodomain PRH/Hex. This competitive mechanism of eIF4E regulation is disrupted in a subset of leukemias, where
HOXA9
displaces PRH from eIF4E, thereby contributing to eIF4E's dysregulation. In regard to these results and our previous finding that approximately 200 homeodomain proteins contain eIF4E binding sites, we propose that homeodomain modulation of eIF4E activity is a novel means through which this family of proteins implements their effects on growth and development.
...
PMID:Eukaryotic translation initiation factor 4E activity is modulated by HOXA9 at multiple levels. 1565 36
