Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:4.1.1.17 (
ornithine decarboxylase
)
6,351
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Different stages of liver regeneration are regulated by a variety of factors such as the liver growth associated protein
ALR
, augmenter of liver regeneration. Furthermore, small molecules like polyamines were proven to be essential for hepatic growth and regeneration. Therefore, using primary human hepatocytes in vitro we investigated the effect of
ALR
on the biosynthesis of polyamines. We demonstrated by HPLC analysis that recombinant
ALR
enhanced intracellular hepatic putrescine, spermidine, and spermine levels within 9-12h. The activation of polyamine biosynthesis was dose dependent with putrescine showing the strongest increase. Additionally,
ALR
treatment induced mRNA expression of
ornithine decarboxylase
(
ODC
) and S-adenosylmethionine decarboxylase, both key enzymes of polyamine biosynthesis. Further,
ALR
induced c-myc mRNA expression, a regulator of
ODC
expression, and therefore we assume that
ALR
exerts its liver regeneration augmenting effects through stimulation of its signalling pathway leading in part to enhanced polyamine synthesis.
...
PMID:Regulation of polyamine synthesis in human hepatocytes by hepatotrophic factor augmenter of liver regeneration. 1667 2
