Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:4.1.1.17 (
ornithine decarboxylase
)
6,351
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Two peaks in cyclic AMP production in rat livers 4 and 12h after partial hepatectomy (MacManus et al., 1972) were confirmed and a third peak established at 22h, which is the peak of DNA synthesis. The increases in cyclic AMP were prevented by beta-adrenergic blocking agents, propranolol and pindolol, without affecting
ornithine decarboxylase
induction or DNA synthesis. The alpha-blocking agents, phenoxybenzamine and phentolamine, given at the time of partial hepatectomy, delayed the rise in
ornithine decarboxylase
normally found 4h after operation, but did not affect DNA synthesis. If the alpha-blocking agents were given at 9-12h or 18h, the onset of DNA synthesis was delayed.
Phenoxybenzamine
did not affect the induction of
ornithine decarboxylase
in intact rat livers by glucagon or growth hormone, but did inhibit induction by dexamethasone. The induction of
ornithine decarboxylase
produced by dexamethasone was inhibited by 17alpha-hydroxy-progesterone; this compound also blocked the induction of
ornithine decarboxylase
in livers of partially hepatectomized rats.
...
PMID:Hormonal control of liver regeneration. 415 33
