Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:4.1.1.17 (
ornithine decarboxylase
)
6,351
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Suicide inhibitors of acetylenic structure can inactive many enzymes playing an important role in the cancer cell metabolism. This type of inhibitors presents a fantastic interest because of its original inhibition mode: it is the catalytic mechanism of the enzyme itself which make the inhibitor reactive. In this way, thymidylate synthetase,
ornithine decarboxylase
, aldehyde dehydrogenase,
aldehyde reductase
are inhibit by acetylenic substrates. These very efficient compounds will allow to envisage a more selective chemotherapy of cancer.
...
PMID:[Acetylenic enzyme inhibitors: their role in anticancer chemotherapy]. 228 2
