Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:4.1.1.17 (ornithine decarboxylase)
 6,351 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Recently GnRH and its synthetic agonists were shown to exert extrapituitary actions and inhibit the growth-promoting effects of testosterone and estradiol. In the present study, the long-term effect of GnRH agonist [des-Gly10, D-Ala6-GnRH ethylamide GnRHa] on the steroid-induced renotropic effect was investigated. Gonadectomy of 30-day old male and female rats resulted in the drastic reduction of kidney ornithine decarboxylase (ODC) activity. Injection of testosterone (75 micrograms/rat) or estradiol (1 microgram/rat) to castrated rats significantly increased the enzyme activity at 24 h. Treatment with the GnRH agonist, two doses of 100 micrograms each, caused significant inhibition of the hormone induced ODC activity. Similarly injection of dihydrotestosterone to castrated adult male rats significantly increased poly(A)-polymerase activity at 24 h. Two doses of 100 micrograms of GnRHa caused significant inhibition of DHT induced poly(A)-polymerase activity. These results show that chronic exposure to potent GnRH analogs may have anti-steroidal activity in the kidney.
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PMID:Inhibition of sex-steroid hormone induced ornithine decarboxylase and poly(A)-polymerase activities by a GnRH agonist in the rat kidney. 300 21

The dorsal resting hair of C3H mice at various ages was shaved, thus activating the hair into the anagen stage. New hair growth after shaving was not uniform in the various age groups. Furthermore, an increasing delay in hair regrowth was observed as the mice became older (20, 66, 188, and 312 days). In the biochemical analysis of hair regrowing and nongrowing skins after shaving, activities of ornithine decarboxylase, transglutaminase, and alkaline phosphatase had higher values in the extract of the hair regrowing area compared with that in the nongrowing area. In studying the effects of various physical and chemical treatments on hair growth after shaving, repeated shaving was in itself clearly shown to stimulate hair growth. Amongst all of the treatments that were applied, topical application of TPA was most able to accelerate hair regrowth, followed by UV irradiation and retinoic acid treatment. Suppression of hair regrowth was observed in PUVA, DHT, and estradiol; and complete inhibition was seen in the animals treated with betamethasone valerate. In biochemical studies, a relatively good correlation was observed between the rate of hair regrowth and skin ODC activities after treatment.
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PMID:Regulation mechanisms of hair growth. 614 Jan 29