Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:4.1.1.17 (
ornithine decarboxylase
)
6,351
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Two oral doses of 1,2-dibromoethane (10-300 mumol/kg) were given to adult female rats 21 and 4 hours before sacrifice. Then hepatic DNA damage,
ornithine decarboxylase
, cytochrome P-450 content, glutathione content and serum alanine aminotransferase activity assays were performed. In addition, DNA damage was assessed in blood, bone marrow, kidney, spleen and thymus. Of the six organs studied, liver showed the largest amount of DNA damage. Doses at or above 10 mumol/kg
EDB
caused DNA damage as determined by the alkaline elution technique. Far greater doses (300 mumol/kg, 56.4 mg/kg) of
EDB
were required to cause other biochemical effects, such as increased activity of
ornithine decarboxylase
. Thus, the carcinogen
EDB
caused substantial DNA damage at doses far below those required to show other biochemical effects or frank liver toxicity. DNA damage occurred at a dose level 40-fold lower than that demonstrated in previous studies.
...
PMID:1,2-Dibromoethane causes rat hepatic DNA damage at low doses. 380 Oct 22
