Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.6.4.4 (
kinesin
)
5,033
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Fasciculation and elongation protein zeta-1
(
FEZ1
) promotes efficiently the neurite elongation of rat phaeochromocytoma PC12 cells. We here characterized
FEZ1
in PC12 cells. Nerve growth factor (NGF) stimulation induces significant expression of endogenous
FEZ1
in PC12 cells. Upon NGF stimulation
FEZ1
localizes in both cytoplasm and neuritis, co-localizing with mitochondria. Silencing of
FEZ1
by RNA interference efficiently reduces NGF-induced neurite elongation and the anterograde motility of mitochondria in PC12 cells. Immunoprecipitation and pulldown assay shows that
FEZ1
interacts with kinesin superfamily protein 5 (KIF5) and tubulin. Thus, our results suggest that the
FEZ1
/
kinesin
complex functions for the transport of mitochondria along microtubules toward the extending neurites in differentiating PC12 cells.
...
PMID:Axonal guidance protein FEZ1 associates with tubulin and kinesin motor protein to transport mitochondria in neurites of NGF-stimulated PC12 cells. 1766 66
