Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.6.4.4 (
kinesin
)
5,033
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
In recent years, sodium p-perfluorous nonenoxybenzene sulfonate (
OBS
) has emerged as a substitute for PFOS with large demand and application in the Chinese market. However, little is known about potential developmental effects of
OBS
. In this study, zebrafish embryos were acutely exposed to different concentrations of
OBS
and the positive control PFOS for a comparative developmental toxicity assessment.
OBS
caused hatching delays, body axis curvature, neurobehavioral inhibition and abnormal cardiovascular development. These organismal effects were accompanied by change of development related genes expression profile, in which some cases were similar to PFOS. Overall, the toxic effects induced by
OBS
were generally milder than that of PFOS. Further investigation suggested that both
OBS
and PFOS disrupted ciliogenesis, evidenced by the ciliary immunostaining, changes in gene expression of
kinesin
family, dynein arm family and tubulin family members, as well as downregulation of the abundance of motor proteins including KIF3C, DYNC1H1 and DYNC1LI1. The influence of PFOS was stronger than that of
OBS
on ciliary genes and proteins. Molecular docking analysis revealed that both
OBS
and PFOS fitted into the motor proteins tightly, but binding affinity between
OBS
and motor proteins was lower than PFOS. Collectively,
OBS
and PFOS may act on ciliary motor proteins to interfere with ciliogenesis, leading to ciliary dysfunction and providing a novel probable action mode linked to developmental toxicity. This raises concerns regarding the health risks of the novel PFOS alternative
OBS
.
...
PMID:Developmental toxicity of the novel PFOS alternative OBS in developing zebrafish: An emphasis on cilia disruption. 3322 14
