Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.6.4.4 (
kinesin
)
5,033
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The
enhancer of rudimentary homolog
(
ERH
) is a small eukaryotic protein that is highly conserved in animals, plants, and protists but not in fungi.
ERH
has several binding proteins and has been associated with various cellular processes, such as pyrimidine metabolism, cell cycle progression, and transcription control; however, little is known about the exact role of this protein and the underlying molecular mechanisms. We found that
ERH
has a critical role in the mitotic phase of the cell cycle.
ERH
depleted-cells showed severe chromosome misalignment and weakened kinetochore-microtubule attachment.
ERH
depletion also caused dissociation of centromere-associated protein E (CENP-E), a mitotic
kinesin
that is involved in stabilizing the kinetochore-microtubule attachment, from kinetochores of mitotic chromosomes. We propose that
ERH
contributes to chromosome alignment at the metaphase plate by localizing CENP-E at kinetochore regions.
...
PMID:Enhancer of rudimentary homolog (ERH) plays an essential role in the progression of mitosis by promoting mitotic chromosome alignment. 2270 34
