Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.6.4.4 (
kinesin
)
5,033
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The motor protein
kinesin
-1 plays an important role in polarized sorting of transport vesicles to the axon. However, the mechanism by which the axonal entry of
kinesin
-1-dependent cargo transport is regulated remains unclear. Microtubule-associated protein MAP7 (ensconsin in Drosophila) is an essential
kinesin
-1 cofactor and promotes
kinesin
-1 recruitment to microtubules. Here, we found that MAP7 family member
MAP7D2
concentrates at the proximal axon, where it overlaps with the axon initial segment and interacts with
kinesin
-1. Depletion of
MAP7D2
results in reduced axonal cargo entry and defects in axon development and neuronal migration. We propose a model in which
MAP7D2
in the proximal axon locally promotes
kinesin
-1-mediated cargo entry into the axon.
...
PMID:MAP7D2 Localizes to the Proximal Axon and Locally Promotes Kinesin-1-Mediated Cargo Transport into the Axon. 3078 82
