Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.6.4.4 (
kinesin
)
5,033
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Binding of motor proteins to cellular cargoes is regulated by adaptor proteins.
HAP1
and GRIP1 are
kinesin
-1 adaptors that have been implicated individually in the transport of vesicular cargoes in the dendrites of neurons. We find that HAP1a and GRIP1 form a protein complex in the brain, and co-operate to activate the
kinesin
-1 subunit KIF5C
in vitro
Based upon this co-operative activation of
kinesin
-1, we propose a modification to the
kinesin
activation model that incorporates stabilisation of the central hinge region known to be critical to autoinhibition of
kinesin
-1.
...
PMID:The adaptor proteins HAP1a and GRIP1 collaborate to activate the kinesin-1 isoform KIF5C. 3175 89
