Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.6.4.4 (
kinesin
)
5,033
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
We tested the hypothesis that amyloid precursor protein (APP) and its relatives function as vesicular receptor proteins for
kinesin
-I. Deletion of the Drosophila APP-like gene (Appl) or overexpression of human APP695 or
APPL
constructs caused axonal transport phenotypes similar to
kinesin
and dynein mutants. Genetic reduction of
kinesin
-I expression enhanced while genetic reduction of dynein expression suppressed these phenotypes. Deletion of the C terminus of APP695 or
APPL
, including the
kinesin
binding region, disrupted axonal transport of APP695 and
APPL
and abolished the organelle accumulation phenotype. Neuronal apoptosis was induced only by overexpression of constructs containing both the C-terminal and Abeta regions of APP695. We discuss the possibility that axonal transport disruption may play a role in the neurodegenerative pathology of Alzheimer's disease.
...
PMID:Disruption of axonal transport and neuronal viability by amyloid precursor protein mutations in Drosophila. 1170 51
