Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.6.4.1 (myosin ATPase)
 1,140 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Luciani's ipsilaterally acting 'trophic' cerebellar influence on striated muscle was reinvestigated in hemidecerebellate preparations of varying extent. Cats with hindlimb postural asymmetries for 4 or more days after the lesion developed a bilateral reduction of maximum tetanic tension and increased twitch/tetanus ratios of soleus. In addition, soleus on the side of the lesion lost force and weight, showed decreased twitch contraction and half-relaxation times, elevated myosin ATPase activity in part of its fibres, occasional fibre necrosis and a few snake coils. Protracted postural asymmetry occurred only if complete hemicerebellectomy included ablation of the lateral vestibular nucleus and extended for at least 3.0 mm across the midline into the contralateral vermal and intermediate cortex, especially of Larsell's lobuli IV and V. Most simply, the cerebellar effect on muscle is explained as the result of altered motoneuronal activation patterns. Comparison of the experimental soleus changes with Holmes's clinical findings in cases of cerebellar injury suggests that muscle itself participates in experimental and human cerebellar asthenia.
 ...
PMID:Motor activity and muscle properties in the hemidecerebellate cat. 622 71