Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts: Gene/Protein Disease Symptom Drug Enzyme Compound   Target Concepts: Gene/Protein Disease Symptom Drug Enzyme Compound

---

Query: EC:3.6.3.44 (P-glycoprotein)
13,344 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .

Human Gene/Protein P-glycoprotein 13241 MDR1 1890 ATP 1303 ABCB1 1041 Sep 918 P-gp 779 Mol 767 breast cancer resistance protein 717 ATP-binding cassette 716 ATPase 688 cytochrome P450 648 multidrug resistance-associated protein 493 mdr1 493 CYP3A4 462 MRP1 446 ADR 390 ABC 363 ABCG2 358 BCRP 345 ABCC1 335 ABC transporter 295 CYP3A 266 MRP2 261 MRP 251 p53 240 multidrug resistance protein 235 xenobiotic 192 gut 190 Bcl-2 185 membrane protein 163 caspase-3 153 glycoprotein 152 multidrug resistance protein 1 135 PK1 133 polypeptide 129 GSH 126 tyrosine kinase 116 cytochrome 108 calcium channel 108 colon carcinoma 106 pregnane X receptor 104 ADM 103 CYP 102 glutathione S-transferase 100 CYP2C9 96 CYP2D6 95 CD34 94 organic anion transporting polypeptide 94 ATP-binding cassette transporter 93 osteosarcoma 91 MRK 90 NMR 89 ABCC2 87 CYP2C19 86 multidrug resistance-related protein 85 CYP1A2 83 cytokine 83 multidrug resistance associated protein 83 P450 82 GST 81 endoplasmic reticulum 78 PEG 76 MRP3 76 ADP 75 membrane glycoprotein 73 OATP1B1 70 CYP3A5 69 proximal tubule 68 transporter protein 67 multidrug resistance protein 2 67 MDR protein 66 MRP4 66 ACS 66 organic anion transporter 64 CD4 64 membrane-bound 64 OATP1B3 64 topoisomerase I 62 protease inhibitor 62 MES 62 more...

Disease cancer 3963 tumor 2070 leukemia 699 breast cancer 677 MCF 531 carcinoma 400 acute myeloid leukemia 301 lymphoma 221 hepatocellular carcinoma 216 epilepsy 216 adenocarcinoma 210 CEM 205 HIV 199 lung cancer 176 tumor growth 174 Alzheimer's disease 144 ovarian cancer 135 Leukemia 132 GSH 126 multiple myeloma 122 chronic myeloid leukemia 116 acute lymphoblastic leukemia 116 melanoma 112 colon cancer 108 epithelial ovarian cancer 103 immunodeficiency 98 osteosarcoma 93 glioma 91 lung carcinoma 85 metastases 84 colorectal cancer 80 sarcoma 76 gastric cancer 73 glioblastoma 73 non-small cell lung cancer 73 depression 71 small cell lung cancer 69 neuroblastoma 68 renal cell carcinoma 65 carcinogenesis 65 acute leukemia 65 prostate cancer 65 stroke 64 tumor progression 61 AIDS 59 cystic fibrosis 57 acute promyelocytic leukemia 49 squamous cell carcinoma 47 hypertension 47 diabetes 46 malaria 46 DDP 44 myeloid leukemia 42 solid tumor 41 erythroleukemia 40 inflammatory bowel disease 40 Parkinson's disease 39 renal impairment 39 rheumatoid arthritis 38 cholestasis 37 hepatitis C 37 chronic lymphocytic leukemia 36 tumorigenesis 34 SDS 34 liver cancer 34 metastatic breast cancer 34 SCID 32 neutropenia 32 myelosuppression 32 fibrosarcoma 32 status epilepticus 32 ischemia 32 schizophrenia 31 non-Hodgkin's lymphoma 31 bladder cancer 30 myelodysplastic syndrome 30 B-cell lymphoma 29 Hodgkin's disease 29 SAR 29 brain tumor 28 more...

Symptom seizures 113 pain 50 diarrhea 44 analgesia 31 nausea 25 starvation 21 vomiting 18 constipation 15 anesthesia 12 headache 11 ataxia 9 dizziness 8 angina 8 sleepiness 7 nausea and vomiting 7 fatigue 7 hypothermia 6 cancer pain 4 hepatomegaly 4 insomnia 4 acidity 4 tremor 4 anorexia 4 weakness 3 abdominal pain 3 collapse 3 apathy 3 functional recovery 3 syncope 3 lethargy 3 overweight 2 paresthesia 2 polyuria 2 Ill 2 Fluctuation 2 myalgia 2 flushing 2 skin damage 2 asthenia 2 polydipsia 2 spasticity 2 exhaustion 2 nasal congestion 2 splenomegaly 2 cerebellar ataxia 2 respiratory distress 2 paresis 2 agitation 2 erythema 2 Welt 2 arthralgia 2 hepatosplenomegaly 2 hyperoxia 2 acute stress 1 vertigo 1 ENT 1 dyspnea 1 memory loss 1 tingling 1 tonic-clonic seizure 1 breakthrough pain 1 acute pain 1 muscle rigidity 1 spasm 1 tinnitus 1 shoulder pain 1 bitter taste 1 pleuritic chest pain 1 leg edema 1 colic 1 bone pain 1 adenitis 1 Severe diarrhea 1 night sweats 1 numbness 1 Scratch 1 chronic constipation 1 abdominal cramps 1 renal pain 1 Decreased activity 1 more...

Drug ADR 390 ABC 363 Adriamycin 195 Taxol 117 ADM 113 VCR 101 VCR 93 Cremophor EL 40 CPT-11 39 Tacrolimus 38 Monit 37 CSF 34 ROS 32 Docetaxel 32 IL-2 30 Imatinib 29 lysine 28 Etoposide 27 Glutathione 25 Tariquidar 23 vitamin E 23 caffeine 23 MAP 20 Cardiovasc 20 Ketoconazole 18 Taxotere 17 Gleevec 17 TTC 17 Dermatol 16 Vitamin E 16 IFN-gamma 16 G418 15 Gefitinib 15 Leaf 14 Gel 14 anti-CD33 14 AZT 13 ascorbate 13 AZT 13 Itraconazole 13 Irinotecan 13 Indomethacin 12 Phenytoin 10 Lovastatin 10 Idarubicin 10 ROC 9 Adenosine triphosphate 9 Tetrofosmin 9 Emodin 8 Sorafenib 8 Emodin 8 PMEA 8 Neoral 7 Indinavir 7 Pravastatin 7 ICI 7 Flavopiridol 7 Arsenic trioxide 7 Clopidogrel 7 Dasatinib 7 Miltefosine 7 Oseltamivir 7 ATV 7 Portal 7 Azithromycin 6 G-CSF 6 Vinorelbine 6 Bortezomib 6 ampicillin 6 Fraction 6 Ixabepilone 6 Cremophor RH40 6 Apixaban 6 Cimetidine 6 Fluconazole 6 CTX 6 Vitamin K 6 Trifluoperazine 6 TAT 6 Cimetidine 6 more...

Enzyme P-glycoprotein 13344 ATPase 704 MDR 590 CYP3A4 462 topoisomerase 268 topoisomerase 247 protein kinase C 174 glutathione S-transferase 167 ERK 160 mitogen-activated protein kinase 154 reverse transcriptase 127 caspase-3 122 protein kinase 98 ACS 66 catalase 57 luciferase 55 PARP 51 glutathione peroxidase 46 calcineurin 44 RNA polymerase 42 focal adhesion kinase 40 trypsin 38 UDP-glucuronosyltransferase 38 peroxidase 37 alkaline phosphatase 36 proteasome 35 thymidylate synthase 35 superoxide dismutase 35 Mg2+-ATPase 32 caspase-9 31 RNase 31 RNase 31 transcriptase 30 thromboplastin 30 asparaginase 29 lactate dehydrogenase 27 glucosylceramide synthase 27 dihydrofolate reductase 25 MEK 25 caspase-8 25 gamma-glutamyl transpeptidase 23 chloramphenicol acetyltransferase 19 acetylcholinesterase 17 phosphatidylinositol 3-kinase 17 carboxylesterase 17 phosphodiesterase 17 HIV-1 protease 17 AMPK 16 deoxycytidine kinase 15 thrombin 15 alanine aminotransferase 13 ornithine aminotransferase 13 DNA methyltransferase 12 NO synthase 12 glyceraldehyde-3-phosphate dehydrogenase 12 phosphoinositide 3-kinase 12 NQO1 12 thymidine kinase 11 gamma-glutamylcysteine synthetase 11 aspartate aminotransferase 11 glutathione reductase 11 GSK 11 ribonuclease 10 ribonuclease 10 AMP-activated protein kinase 10 aldehyde dehydrogenase 9 monoamine oxidase 9 granzyme B 9 neuraminidase 9 CD13 9 aldehyde dehydrogenase 9 demethylase 9 kinesin 8 CPT 8 CPT 8 cdc2 8 CPT 8 collagenase 8 DNA polymerase 8 endonuclease 8 more...

Compound ATP 1303 Dec 940 DNA 763 Clin 639 MDR 590 ADR 511 MTT 330 Adriamycin 328 sodium 288 Verapamil 269 Verapamil 268 water 257 PEG 207 oxygen 207 calcium 192 Cyclosporine 156 GSH 143 GSH 143 VP-16 132 Rhodamine 123 131 glucose 125 bromide 123 sulfate 120 acetate 117 hydrogen 116 PEG 116 cysteine 103 phosphate 102 Paclitaxel 98 MDA 92 SDZ PSC 833 87 salt 83 Vinca 81 ADP 78 ADP 75 ADP 75 FK506 72 tyrosine 72 iodine 70 Digoxin 69 Hoechst 33342 68 ACS 66 ACS 66 Rhodamine B 65 Phe 64 acridine 64 SN-38 64 nitrogen 63 MES 62 MES 62 alanine 61 Pluronic 59 galactose 57 glutamate 54 Vinblastine 51 retinoic acid 51 DDP 49 nitric oxide 48 ethanol 48 threonine 48 serine 47 TNF 46 lysine 43 arginine 43 cAMP 42 Rifampicin 41 SDS 40 CPT-11 39 leucine 38 Cereb 38 copper 38 potassium 37 5-FU 37 cadmium 37 quinoline 36 acetonitrile 36 quinoline 36 methionine 35 ammonium 34 methanol 34 more...

---