Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.6.3.44 (P-glycoprotein)
 13,344 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
P-glycoprotein 13241
MDR1 1890
ATP 1303
ABCB1 1041
Sep 918
P-gp 779
Mol 767
breast cancer resistance protein 717
ATP-binding cassette 716
ATPase 688
cytochrome P450 648
mdr1 493
multidrug resistance-associated protein 493
CYP3A4 462
MRP1 446
ADR 390
ABC 363
ABCG2 358
BCRP 345
ABCC1 335
ABC transporter 295
CYP3A 266
MRP2 261
MRP 251
p53 240
multidrug resistance protein 235
xenobiotic 192
gut 190
Bcl-2 185
membrane protein 163
caspase-3 153
glycoprotein 152
multidrug resistance protein 1 135
PK1 133
polypeptide 129
GSH 126
tyrosine kinase 116
cytochrome 108
calcium channel 108
colon carcinoma 106
pregnane X receptor 104
ADM 103
CYP 102
glutathione S-transferase 100
CYP2C9 96
CYP2D6 95
CD34 94
organic anion transporting polypeptide 94
ATP-binding cassette transporter 93
osteosarcoma 91
MRK 90
NMR 89
ABCC2 87
CYP2C19 86
multidrug resistance-related protein 85
multidrug resistance associated protein 83
cytokine 83
CYP1A2 83
P450 82
GST 81
endoplasmic reticulum 78
MRP3 76
PEG 76
ADP 75
membrane glycoprotein 73
OATP1B1 70
CYP3A5 69
proximal tubule 68
multidrug resistance protein 2 67
transporter protein 67
MRP4 66
ACS 66
MDR protein 66
CD4 64
organic anion transporter 64
OATP1B3 64
membrane-bound 64
transmembrane protein 62
MES 62
topoisomerase I 62
protease inhibitor 62
AML 61
AKT 60
tumor necrosis factor 60
lymphoid 59
annexin V 59
organic cation transporter 58
LRP 58
MAPK 57
PI3K 57
mTOR 56
Rho 55
Walker 54
cystic fibrosis transmembrane conductance regulator 53
epidermal growth factor receptor 53
brain) 52
bile salt export pump 51
albumin 50
catalase 49
MDR3 48
PKC 48
OATP2B1 47
microsomal 47
cytochrome P-450 47
TNF 46
Breast Cancer Resistance Protein 46
bcl-2 46
metallothionein 45
ABCC 45
estrogen receptor 44
beta-tubulin 44
occludin 44
MRP5 44
PARP 44
OCT1 43
CD44 43
glutathione peroxidase 42
fused 42
histone deacetylase 41
DNA gyrase 41
catenin 41
glucose transporter 40
p38 40
calmodulin 40
Transporter 40
ERK1 40
FK506 39
caspase-9 39
PGP 39
cytochrome c 39
OAT3 39
nuclear receptor 38
cyclooxygenase-2 38
chloride channel 38
CYP2B6 38
calcineurin 38
lipopolysaccharide 37
caveolin-1 37
solute carrier 36
EGFR 36
CFTR 36
alkaline phosphatase 36
ERK 36
member 1 35
IL-6 35
CD8 35
MDR2 35
proteasome 34
survivin 34
SDS 34
ZO-1 33
Fas 33
DDP 33
interferon 33
PXR 33
intestine, liver 33
vascular endothelial growth factor 32
HEK 32
JNK 32
AMP 32
more...
Disease
cancer 3963
tumor 2070
leukemia 699
breast cancer 677
MCF 531
carcinoma 400
acute myeloid leukemia 301
lymphoma 221
hepatocellular carcinoma 216
epilepsy 216
adenocarcinoma 210
CEM 205
HIV 199
lung cancer 176
tumor growth 174
Alzheimer's disease 144
ovarian cancer 135
Leukemia 132
GSH 126
multiple myeloma 122
chronic myeloid leukemia 116
acute lymphoblastic leukemia 116
melanoma 112
colon cancer 108
epithelial ovarian cancer 103
immunodeficiency 98
osteosarcoma 93
glioma 91
lung carcinoma 85
metastases 84
colorectal cancer 80
sarcoma 76
non-small cell lung cancer 73
gastric cancer 73
glioblastoma 73
depression 71
small cell lung cancer 69
neuroblastoma 68
prostate cancer 65
acute leukemia 65
carcinogenesis 65
renal cell carcinoma 65
stroke 64
tumor progression 61
AIDS 59
cystic fibrosis 57
acute promyelocytic leukemia 49
squamous cell carcinoma 47
hypertension 47
malaria 46
diabetes 46
DDP 44
myeloid leukemia 42
solid tumor 41
inflammatory bowel disease 40
erythroleukemia 40
Parkinson's disease 39
renal impairment 39
rheumatoid arthritis 38
cholestasis 37
hepatitis C 37
chronic lymphocytic leukemia 36
metastatic breast cancer 34
tumorigenesis 34
liver cancer 34
SDS 34
SCID 32
ischemia 32
status epilepticus 32
neutropenia 32
myelosuppression 32
fibrosarcoma 32
schizophrenia 31
non-Hodgkin's lymphoma 31
bladder cancer 30
myelodysplastic syndrome 30
Hodgkin's disease 29
B-cell lymphoma 29
SAR 29
brain tumor 28
liver cancer 27
blast crisis 26
childhood ALL 25
T-cell lymphoma 25
worms 25
rhabdomyosarcoma 24
ulcerative colitis 24
Epstein 24
chronic lymphocytic leukemia 23
tuberculosis 23
uterine sarcoma 23
glioblastoma multiforme 22
temporal lobe epilepsy 21
ABL 21
cervical cancer 21
fits 20
dementia 20
heart failure 20
pancreatic cancer 19
infectious diseases 19
hematologic malignancies 19
leishmaniasis 19
liver disease 18
lymphoblastic leukemia 18
renal cancer 18
brain metastases 18
amyotrophic lateral sclerosis 18
SEM 17
systemic lupus erythematosus 17
colitis 17
PCL 17
renal failure 17
CNS diseases 17
asthma 16
renal disease 16
Crohn's disease 16
Blocking 15
cold 15
WT1 15
secondary AML 15
type 2 diabetes 15
CSA 14
chronic renal failure 14
arthritis 14
congestive heart failure 14
aggressiveness 14
major depressive disorder 14
metastatic melanoma 14
cardiovascular disease 13
hypercholesterolemia 13
thrombocytopenia 13
retinoblastoma 13
influenza 13
primary tumor 13
T-cell acute lymphoblastic leukemia 13
head and neck cancer 13
hyperlipidemia 12
multiple sclerosis 12
TEM 12
cirrhosis 12
adenoma 12
T-cell lymphomas 12
Hepatocellular carcinoma 11
choriocarcinoma 11
residual disease 11
Ewing's sarcoma 11
NAME 11
B-cell chronic lymphocytic leukemia 11
Placenta 11
MTS 11
anemia 11
hyperbilirubinemia 10
TEM 10
plaque 10
sepsis 10
dysplasia 10
brain cancer 10
sepsis 10
chronic hepatitis 10
obesity 10
more...
Symptom
seizures 113
pain 50
diarrhea 44
analgesia 31
nausea 25
starvation 21
vomiting 18
constipation 15
anesthesia 12
headache 11
ataxia 9
dizziness 8
angina 8
sleepiness 7
nausea and vomiting 7
fatigue 7
hypothermia 6
hepatomegaly 4
insomnia 4
tremor 4
cancer pain 4
acidity 4
anorexia 4
functional recovery 3
weakness 3
collapse 3
syncope 3
apathy 3
abdominal pain 3
lethargy 3
overweight 2
paresthesia 2
polyuria 2
Ill 2
Fluctuation 2
myalgia 2
flushing 2
skin damage 2
polydipsia 2
arthralgia 2
spasticity 2
paresis 2
exhaustion 2
splenomegaly 2
nasal congestion 2
respiratory distress 2
hepatosplenomegaly 2
agitation 2
asthenia 2
cerebellar ataxia 2
erythema 2
Welt 2
hyperoxia 2
acute stress 1
vertigo 1
ENT 1
dyspnea 1
memory loss 1
tingling 1
tonic-clonic seizure 1
bradykinesia 1
spasm 1
acute pain 1
Sedation 1
frequent urination 1
muscle rigidity 1
tinnitus 1
shoulder pain 1
bitter taste 1
pleuritic chest pain 1
leg edema 1
colic 1
bone pain 1
adenitis 1
Severe diarrhea 1
night sweats 1
breakthrough pain 1
numbness 1
Scratch 1
chronic constipation 1
abdominal cramps 1
renal pain 1
Decreased activity 1
low back pain 1
Drug
ADR 390
ABC 363
Adriamycin 195
Taxol 117
ADM 113
VCR 101
VCR 93
Cremophor EL 40
CPT-11 39
Tacrolimus 38
Monit 37
CSF 34
ROS 32
Docetaxel 32
IL-2 30
Imatinib 29
lysine 28
Etoposide 27
Glutathione 25
caffeine 23
Tariquidar 23
vitamin E 23
Cardiovasc 20
MAP 20
Ketoconazole 18
TTC 17
Gleevec 17
Taxotere 17
Vitamin E 16
IFN-gamma 16
Dermatol 16
Gefitinib 15
G418 15
Leaf 14
anti-CD33 14
Gel 14
AZT 13
Irinotecan 13
ascorbate 13
AZT 13
Itraconazole 13
Indomethacin 12
Idarubicin 10
Phenytoin 10
Lovastatin 10
ROC 9
Adenosine triphosphate 9
Tetrofosmin 9
PMEA 8
Emodin 8
Emodin 8
Sorafenib 8
Pravastatin 7
Neoral 7
Indinavir 7
Dasatinib 7
Miltefosine 7
Arsenic trioxide 7
Flavopiridol 7
ATV 7
Portal 7
Oseltamivir 7
ICI 7
Clopidogrel 7
Bortezomib 6
Trifluoperazine 6
G-CSF 6
ampicillin 6
CTX 6
Vinorelbine 6
Cimetidine 6
TAT 6
Azithromycin 6
Cimetidine 6
Ixabepilone 6
Fluconazole 6
Vitamin K 6
Cremophor RH40 6
Apixaban 6
Fraction 6
TAK 5
Novantrone 5
Glycyrrhiza 5
Flupenthixol 5
MDS 5
Fluorescein 5
Rutin 5
Ethanol 5
Poloxamer 188 5
Darunavir 5
ENT 5
AraC 5
Prednisolone 5
balanced salt solution 5
Paraffin 5
Trabectedin 4
Photofrin 4
Aloe 4
Tolvaptan 4
Nephron 4
Everolimus 4
Asn 4
TAC 4
Simvastatin 4
TEL 4
Podophyllotoxin 4
CTT 4
DM1 4
Gramicidin D 4
EPI 4
Atenolol 4
Moxidectin 4
Meth 4
Fluorescein 4
Etravirine 4
Navelbine 4
Retinoic acid 4
MRC 4
Nephron 4
Hyperforin 4
ACT 3
-deoxyadenosine 3
CTX 3
DEX 3
Felodipine 3
DNase I 3
HCH 3
PCB 3
Domperidone 3
Erlotinib 3
CTX 3
CTC 3
NADH 3
Quinine, 3
ddI 3
Myricetin 3
CTC 3
lactose 3
K-252a 3
Valsartan 3
Gemfibrozil 3
PCP 3
Micafungin 3
Orphan 3
Prednisone 3
Posaconazole 3
Loratadine 3
Amdray 3
TPV 3
Reserpine 3
Aliskiren 3
Monensin 3
Dronedarone 3
Ranitidine 3
Fentanyl 3
Raloxifene 3
Tykerb 3
NVP 3
Digitalis 3
Maraviroc 3
more...
Enzyme
P-glycoprotein 13344
ATPase 704
MDR 590
CYP3A4 462
topoisomerase 268
topoisomerase 247
protein kinase C 174
glutathione S-transferase 167
ERK 160
mitogen-activated protein kinase 154
reverse transcriptase 127
caspase-3 122
protein kinase 98
ACS 66
catalase 57
luciferase 55
PARP 51
glutathione peroxidase 46
calcineurin 44
RNA polymerase 42
focal adhesion kinase 40
trypsin 38
UDP-glucuronosyltransferase 38
peroxidase 37
alkaline phosphatase 36
superoxide dismutase 35
thymidylate synthase 35
proteasome 35
Mg2+-ATPase 32
caspase-9 31
RNase 31
RNase 31
thromboplastin 30
transcriptase 30
asparaginase 29
lactate dehydrogenase 27
glucosylceramide synthase 27
dihydrofolate reductase 25
caspase-8 25
MEK 25
gamma-glutamyl transpeptidase 23
chloramphenicol acetyltransferase 19
carboxylesterase 17
HIV-1 protease 17
phosphatidylinositol 3-kinase 17
phosphodiesterase 17
acetylcholinesterase 17
AMPK 16
thrombin 15
deoxycytidine kinase 15
alanine aminotransferase 13
ornithine aminotransferase 13
NQO1 12
DNA methyltransferase 12
phosphoinositide 3-kinase 12
NO synthase 12
glyceraldehyde-3-phosphate dehydrogenase 12
glutathione reductase 11
thymidine kinase 11
GSK 11
aspartate aminotransferase 11
gamma-glutamylcysteine synthetase 11
ribonuclease 10
ribonuclease 10
AMP-activated protein kinase 10
aldehyde dehydrogenase 9
demethylase 9
CD13 9
granzyme B 9
neuraminidase 9
aldehyde dehydrogenase 9
monoamine oxidase 9
CPT 8
CPT 8
kinesin 8
cdc2 8
DNA polymerase 8
CPT 8
collagenase 8
endonuclease 8
histidine permease 7
aldehyde dehydrogenase 7
CD10 7
endoglycosidase H 7
glyceraldehyde-3-phosphate dehydrogenase 7
aldehyde dehydrogenase 7
DCF 7
aldehyde dehydrogenase 7
renin 7
MPP 7
creatine kinase 7
succinate dehydrogenase 7
thiopurine methyltransferase 7
TAT 6
IKK 6
protein phosphatase 2A 6
PNGase F 6
glyceraldehyde-3-phosphate dehydrogenase 6
beta-galactosidase 6
ACE 6
glyceraldehyde-3-phosphate dehydrogenase 6
glyceraldehyde-3-phosphate dehydrogenase 6
phospholipase C 6
thioredoxin reductase 5
glucocerebrosidase 5
cathepsin B 5
caspase-2 5
firefly luciferase 5
dihydropyrimidine dehydrogenase 5
carbonic anhydrase 5
hexokinase 5
Protein 2 5
dihydropyrimidine dehydrogenase 5
acid phosphatase 5
3-hydroxy-3-methylglutaryl coenzyme A reductase 5
caspase-2 5
sphingomyelin synthase 4
cholesterol acyltransferase 4
MTD 4
6beta-hydroxylase 4
NADPH oxidase 4
AMPK 4
APC 4
CPR 4
CEP 4
histone acetyltransferase 4
ricin 4
hypoxanthine-guanine phosphoribosyltransferase 4
aldose reductase 4
TdT 4
PAH 4
sphingosine kinase 4
CEP 4
ALDH 4
BMT 3
cytosine deaminase 3
AST 3
PCP 3
caspase-6 3
adenosine deaminase 3
cysteine synthase 3
pyruvate carboxylase 3
MAT 3
NADPH oxidase 3
glucose-6-phosphate dehydrogenase 3
flavin-containing monooxygenase 3
adenosine deaminase 3
dipeptidyl peptidase IV 3
cytidine deaminase 3
cathepsin D 3
PHT 3
ATP synthase 3
paraoxonase 3
glutamate dehydrogenase 3
methylenetetrahydrofolate reductase 3
NOS 3
chymotrypsin 3
5'-nucleotidase 3
matrix metalloproteinase 2 3
tryptase 3
more...
Compound
ATP 1303
Dec 940
DNA 763
Clin 639
MDR 590
ADR 511
MTT 330
Adriamycin 328
sodium 288
Verapamil 269
Verapamil 268
water 257
PEG 207
oxygen 207
calcium 192
Cyclosporine 156
GSH 143
GSH 143
VP-16 132
Rhodamine 123 131
glucose 125
bromide 123
sulfate 120
acetate 117
hydrogen 116
PEG 116
cysteine 103
phosphate 102
Paclitaxel 98
MDA 92
SDZ PSC 833 87
salt 83
Vinca 81
ADP 78
ADP 75
ADP 75
tyrosine 72
FK506 72
iodine 70
Digoxin 69
Hoechst 33342 68
ACS 66
ACS 66
Rhodamine B 65
acridine 64
SN-38 64
Phe 64
nitrogen 63
MES 62
MES 62
alanine 61
Pluronic 59
galactose 57
glutamate 54
Vinblastine 51
retinoic acid 51
DDP 49
ethanol 48
nitric oxide 48
threonine 48
serine 47
TNF 46
arginine 43
lysine 43
cAMP 42
Rifampicin 41
SDS 40
CPT-11 39
Cereb 38
leucine 38
copper 38
cadmium 37
potassium 37
5-FU 37
quinoline 36
acetonitrile 36
quinoline 36
methionine 35
NH2 34
ammonium 34
methanol 34
Curcumin 33
AMP 32
Methotrexate 32
pyridine 31
creatinine 31
kaempferol 30
His 30
Tamoxifen 29
Daunorubicin 29
uridine 29
Tamoxifen 29
Colchicine 29
Tween 80 29
HCl 28
Gly 27
5-HT 26
tryptophan 26
diacetate 26
pyrene 26
tryptophan 26
tryptophan 26
Quercetin 26
urea 26
Vincristine 26
tryptophan 26
Calcein 25
UDP 25
BCR 24
NADPH 24
N-acetylcysteine 24
iron 24
NADPH 24
ABL 23
caffeine 23
benzoic acid 22
valine 22
zinc 21
Ritonavir 21
piperazine 21
Asp 21
Ara-C 20
Docetaxel 20
Quinidine 20
Ara-C 20
m-AMSA 19
hyaluronic acid 19
vitamin D 19
MTX 19
pyrimidine 19
Triton X-100 19
pyrimidine 19
Progesterone 18
GTP 18
Ketoconazole 18
Fexofenadine 17
Pac 17
Morphine 17
VM-26 17
Dexamethasone 17
LTC4 17
Ivermectin 17
aldosterone 17
isoquinoline 17
Vitamin E 17
glycerol 17
phenol 17
MEK 17
TEM 16
THP 16
Cholesterol 16
Rapamycin 16
glutamine 16
Berberine 16
benzene 16
Loperamide 16
Probenecid 15
DPH 15
GABA 15
Genistein 15
more...