Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.6.3.44 (
P-glycoprotein
)
13,344
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
P-glycoprotein
(
P-gp
)/ABCB1 is a key molecule of multidrug resistance in cancer. Protein phosphatase (PP) 2A, regulatory subunit B, gamma (
PPP2R3C
), which is a regulatory subunit of PP2A and PP5, was identified as a binding candidate to
P-gp
. Immunoprecipitation-western blotting revealed that PP5 and
PPP2R3C
were coprecipitated with
P-gp
, while PP2A was not. PP5/
PPP2R3C
dephosphorylated protein kinase A/protein kinase C-phosphorylation of
P-gp
. Knockdown of PP5 and/or
PPP2R3C
increased
P-gp
expression and lowered the sensitivity to vincristine and doxorubicin. Consequently, our results indicate that PP5/
PPP2R3C
negatively regulates
P-gp
expression and function.
...
PMID:Protein phosphatase complex PP5/PPP2R3C dephosphorylates P-glycoprotein/ABCB1 and down-regulates the expression and function. 2433 28
