Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.6.3.44 (
P-glycoprotein
)
13,344
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
We have isolated and sequenced a novel cDNA clone (
D320
), from methotrexate-selected multidrug-resistant (MDR) human leukemic CCRF-CEM cells, which encodes a peptide reactive with monoclonal antibody (mAb) C219. Despite having been cloned using this ostensibly
P-glycoprotein
-specific mAb, clone
D320
has no significant homology with either the MDR-encoding gene or, at the amino acid (aa) level, with its product,
P-glycoprotein
. A putative C219-binding site has been identified in
D320
, which differs at two positions from the 6-aa C219 epitope previously described in
P-glycoprotein
.
...
PMID:Analysis of a novel cDNA encoding a C219-reactive peptide isolated from methotrexate-selected multidrug-resistant human leukemic cells. 775 77
