Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.6.3.44 (
P-glycoprotein
)
13,344
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
In the present study, we investigated the roles of
PDCD5
(programmed cell death 5) in multidrug re-sistance (MDR) of osteosarcoma cells and the possible lurking mechanisms. An adenovirus expression vector of
PDCD5
was constructed and transfected into human adriamycin-resistant osteosarcoma cell line Saos-2/ADM. We found that up-regulation of
PDCD5
could significantly enhance the sensitivity of Saos-2/ADM cells towards vincristine, methotrexate, cisplatin and arsenic trioxide (As2O3), and could decrease the capacity of cells to efflux adriamycin.
PDCD5
could significantly down regulate the expression of
P-glycoprotein
(Pgp), but not affect the expression of multidrug resistance associated protein (MRP) or the glutathione S-transferase (GST).
PDCD5
was also able to significantly increase the apoptotic activity of modified osteosarcoma cells. Further study of the biological functions of
PDCD5
might be helpful in the understanding of the mechanisms of multidrug resistance (MDR) in osteosarcoma and exploring
PDCD5
based adjuvant genetic therapy.
...
PMID:Adenovirus-delivered PDCD5 counteracts adriamycin resistance of osteosarcoma cells through enhancing apoptosis and inhibiting Pgp. 2566 52
