Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.6.3.44 (
P-glycoprotein
)
13,344
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
We studied the effect of oxatomide, an antiallergic drug, on the resistance of K562 cells to doxorubicin.
Oxatomide
synergistically potentiated the cytotoxicity of doxorubicin in doxorubicin-resistant K562 cells (K562/DXR) at a concentration of 1-10 microM, but had hardly any synergistic effect on the parental cell line (K562) at the same concentration.
Oxatomide
inhibit
P-glycoprotein
pump-efflux activity and the binding of [3H]-azidopine to the cell-surface protein
P-glycoprotein
, in a dose-related manner. These results indicate that oxatomide reverses the multidrug-resistance phenotype through direct interaction with
P-glycoprotein
.
...
PMID:Circumvention of acquired resistance to doxorubicin in K562 human leukemia cells by oxatomide. 1164 29
