Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.6.3.44 (
P-glycoprotein
)
13,344
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The multidrug resistance (
NDR
) phenotype describes a pattern of cross-resistance to unrelated compounds observed in mammalian cell lines selected in vitro for resistance to a single agent. Overexpression of a 170,000 dalton cell membrane glycoprotein (
P-glycoprotein
) is associated consistently with this phenotype in these cell lines. Recently, several human tumours have been shown to contain
P-glycoprotein
and expression was greatest in tumours exhibiting clinical drug resistance. To explore further the significance of
P-glycoprotein
, we examined normal human tissues obtained at autopsy by polyacrylamide gel electrophoresis and immunoblotting using a monoclonal antibody directed against
P-glycoprotein
. We showed expression of
P-glycoprotein
in normal liver and small bowel mucosa but not in other organs examined. This suggests there may be significant expression of
P-glycoprotein
in certain normal human tissues and any plan to exploit
P-glycoprotein
clinically must take these findings into account.
...
PMID:Identification of a multidrug resistance associated antigen (P-glycoprotein) in normal human tissues. 289 67
